Protein detail
SUCR1
Succinate receptor 1 (G-protein coupled receptor 91) (P2Y purinoceptor 1-like)
Entry name SUCR1 | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 3 | Transmembrane count 7 | Protein classification G-protein coupled receptorsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Succinate receptor 1 (G-protein coupled receptor 91) (P2Y purinoceptor 1-like)
Protein Class (2)
G-protein coupled receptorsPredicted membrane proteins
Protein Function
G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
32..52; Helical; Name=1; 60..80; Helical; Name=2; 104..124; Helical; Name=3; 138..158; Helical; Name=4; 186..206; Helical; Name=5; 231..251; Helical; Name=6; 282..302; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym
GPR91
Gene Description
Succinate receptor 1
Chromosome
3
Position
151873643-151884619
Supporting publications (n)
3
EVMP confidence score
0.25
Fluorescence & Localization1
Cell SpecificPlatelets
Function & Pathway7
Protein Function
G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component (2)
Molecular Function (3)
Biological Process (3)
Reactome (4)
Mediation Categories (3)
Immune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence39
Ligand-Receptor Signaling (38)
38 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| receptor | receptor | scConnect | No | Yes | No | Yes | No |
| receptor | receptor | Almen2009 | No | Yes | No | Yes | No |
| receptor | receptor | CellCellInteractions | No | Yes | No | Yes | No |
| gpcr | receptor | GPCRdb | No | Yes | No | Yes | No |
| succinate | receptor | HGNC | No | Yes | No | Yes | No |
| receptor | receptor | HGNC | No | Yes | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Western BlottingMass SpectrometryElisa | 1 | 34771645 |
Sequence, Structure & Domains9
Sequences
Length
334
Mass
38,698
Sequence
MLGIMAWNATCKNWLAAEAALEKYYLSIFYGIEFVVGVLGNTIVVYGYIFSLKNWNSSNIYLFNLSVSDLAFLCTLPMLIRSYANGNWIYGDVLCISNRYVLHANLYTSILFLTFISIDRYLIIKYPFREHLLQKKEFAILISLAIWVLVTLELLPILPLINPVITDNGTTCNDFASSGDPNYNLIYSMCLTLLGFLIPLFVMCFFYYKIALFLKQRNRQVATALPLEKPLNLVIMAVVIFSVLFTPYHVMRNVRIASRLGSWKQYQCTQVVINSFYIVTRPLAFLNSVINPVFYFLLGDHFRDMLMNQLRHNFKSLTSFSRWAHELLLSFREK
3D Structural Models
Turn
158..160; 175..177; 312..316
Helix
12..48; 57..73; 76..85; 92..125; 132..134; 136..154; 155..157; 181..195; 197..216; 228..258; 270..285; 287..296; 300..308
Beta Strand
49..51; 164..166; 169..171; 222..224; 261..263
3D Structure
Electron microscopy (7)
Domain & Motif Annotations
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance1
Antibody
Supporting Publications3
| PMID | Title | Abstract |
|---|---|---|
| 37403840 | Phosphoproteome analysis of cerebrospinal fluid extracellular vesicles in primary central nervous system lymphoma. | No abstract available |
| 38576002 | Therapy-induced senescent tumor cell-derived extracellular vesicles promote colorectal cancer progression through SERPINE1-mediated NF-κB p65 nuclear translocation. | No abstract available |
| 38871114 | Proteomic analysis of endothelial cells and extracellular vesicles in response to indoxyl sulfate: Mechanisms of endothelial dysfunction in chronic kidney disease. | No abstract available |