Protein detail

OSB10

Oxysterol-binding protein-related protein 10 (ORP-10) (OSBP-related protein 10)

Entry name OSB10	UniProt ID Q9BXB5	EVMP confidence score 0.38
Supporting publications (n) 3	Transmembrane count	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information6

Protein Names

Oxysterol-binding protein-related protein 10 (ORP-10) (OSBP-related protein 10)

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000144645

Entrez Gene Symbol

OSBPL10

Supporting publications (n)

EVMP confidence score

0.38

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (3)

Molecular Function (4)

Biological Process (3)

Reactome (4)

Mediation Categories (2)

Fusion and delivery mediationMetabolism mediation

Relations & Evidence10

Ligand-Receptor Signaling (5)

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (4)

4 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
OSBPL9-OSBPL10 oxysterol-binding protein-related complex	OSBPL10 OSBPL9	Q96SU4 Q9BXB5	1:1	ComplexPortal		36071159 14755292 36853333
	OSBPL10 OSBPL9 PGAM5 RNPS1 SAP18 VAPA VAPB	O00422 O95292 Q15287 Q96HS1 Q96SU4 Q9BXB5 Q9P0L0	1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7880
	ARMC6 OSBPL10 PGAM5 RNPS1 SAP18	O00422 Q15287 Q6NXE6 Q96HS1 Q9BXB5	1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8852
	OSBPL10 OSBPL11 OSBPL9 PGAM5 UBC	P0CG48 Q96HS1 Q96SU4 Q9BXB4 Q9BXB5	1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8931

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometryMass spectrometry [LTQ-FT Ultra]	2	37047601 38555374

Sequence, Structure & Domains12

Sequences

Length

764

Mass

83,970

Sequence

MERAVQGTDGGGGSNSSSRSSSRATSAGSSPSCSLAGRGVSSRSAAAGLGGGGSRSSPGSVAASPSGGGGRRREPALEGVLSKYTNLLQGWQNRYFVLDFEAGILQYFVNEQSKHQKPRGVLSLSGAIVSLSDEAPHMLVVYSANGEMFKLRAADAKEKQFWVTQLRACAKYHMEMNSKSAPSSRSRSLTLLPHGTPNSASPCSQRHLSVGAPGVVTITHHKSPAAARRAKSQYSGQLHEVREMMNQVEGQQKNLVHAIESLPGSGPLTALDQDLLLLKATSAATLSCLGECLNLLQQSVHQAGQPSQKPGASENILGWHGSKSHSTEQLKNGTLGSLPSASANITWAILPNSAEDEQTSQPEPEPNSGSELVLSEDEKSDNEDKEETELGVMEDQRSIILHLISQLKLGMDLTKVVLPTFILEKRSLLEMYADFMAHPDLLLAITAGATPEERVICFVEYYLTAFHEGRKGALAKKPYNPIIGETFHCSWEVPKDRVKPKRTASRSPASCHEHPMADDPSKSYKLRFVAEQVSHHPPISCFYCECEEKRLCVNTHVWTKSKFMGMSVGVSMIGEGVLRLLEHGEEYVFTLPSAYARSILTIPWVELGGKVSINCAKTGYSATVIFHTKPFYGGKVHRVTAEVKHNPTNTIVCKAHGEWNGTLEFTYNNGETKVIDTTTLPVYPKKIRPLEKQGPMESRNLWREVTRYLRLGDIDAATEQKRHLEEKQRVEERKRENLRTPWKPKYFIQEGDGWVYFNPLWKAH

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BXB5-1; Sequence=Displayed; Name=2; IsoId=Q9BXB5-2; Sequence=VSP_042930

Alternative Sequence

180..243; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

15..47; Low complexity; 55..65; Low complexity; 359..370; Polar residues; 374..389; Acidic residues; 511..520; Basic and acidic residues

Coiled Coil

713..740

Domain (CC)

The C-terminal region binds cholesterol, 25-hydroxysterol and acidic phospholipids and is required for localization to microtubules.; DOMAIN: The PH domain selectively interacts with phosphatidylinositol-4-phosphate.

Domain (FT)

74..171; PH

Region

1..74; Disordered; 304..335; Disordered; 354..391; Disordered; 501..520; Disordered

Protein Families

OSBP family

Sequence Similarities

Belongs to the OSBP family.

Clinical Relevance3

Interaction Protein (2)

ENSG00000101558ENSG00000124164

Interaction Count

Interaction Dataset

biogrid_opencell

Supporting Publications3

PMID	Title	Abstract
25037567	Sortilin mediates the release and transfer of exosomes in concert with two tyrosine kinase receptors.	In this study, we demonstrate, in human lung cancer A549 cells, that the exosome release mechanism is closely linked to the multifaceted receptor sortilin (also called neurotensin receptor 3). This new complex (termed the TES complex) is found in exosomes and results in the linkage of the two tyrosine kinase receptors TrkB (also known as NTRK2) and EGFR with sortilin. Using in vitro models, we demonstrate that this sortilin-containing complex exhibits a control on endothelial cells and angiogenesis activation through exosome transfer.
37704750	Lactobacillus-derived extracellular vesicles counteract Aβ42-induced abnormal transcriptional changes through the upregulation of MeCP2 and Sirt1 and improve Aβ pathology in Tg-APP/PS1 mice.	No abstract available
38321007	TrkB phosphorylation in serum extracellular vesicles correlates with cognitive function enhanced by ergothioneine in humans.	No abstract available