Protein detail
GP174
Probable G-protein coupled receptor 174
Entry name GP174 | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 1 | Transmembrane count 7 | Protein classification G-protein coupled receptorsPredicted membrane proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Probable G-protein coupled receptor 174
Protein Class (2)
G-protein coupled receptorsPredicted membrane proteins
Protein Function (2)
- G-protein coupled receptors:Adenosine and adenine nucleotide receptors
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
28..48; Helical; Name=1; 54..74; Helical; Name=2; 92..112; Helical; Name=3; 135..155; Helical; Name=4; 183..203; Helical; Name=5; 232..252; Helical; Name=6; 270..290; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym
FKSG79
Gene Description
G protein-coupled receptor 174
Chromosome
X
Position
79144688-79175318
Supporting publications (n)
1
EVMP confidence score
0.53
Function & Pathway
Protein Function (2)
- G-protein coupled receptors:Adenosine and adenine nucleotide receptors
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component (3)
Molecular Function (2)
Biological Process (3)
Mediation Categories
Immune mediation
Relations & Evidence47
Ligand-Receptor Signaling (40)
40 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| gpcr | receptor | Surfaceome | Yes | Yes | |||
| class_a_rhodopsin | receptor | GPCRdb | Yes | Yes | |||
| class_a_rhodopsin_orphan | receptor | GPCRdb | Yes | Yes | |||
| class_a_rhodopsin_orphan_class_a_orphans | receptor | GPCRdb | Yes | Yes | |||
| receptor | receptor | OmniPath | Yes | Yes | |||
| extracellular | extracellular | HPMR | Yes | ||||
| extracellular | extracellular | OmniPath | Yes | ||||
| intracellular | intracellular | GO_Intercell | Yes | ||||
| intracellular | intracellular | OmniPath | Yes | ||||
| transmembrane | transmembrane | UniProt_location | Yes |
Regulatory Interaction Network (6)
6 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| GP174 | Q9BXC1 | GNAS3 | O95467 | Yes | Yes | HINTSIGNOR | HINT:37737235HINT:38048360SIGNOR:31160049 | |
| GP174 | Q9BXC1 | ALEX | P84996 | Yes | Yes | HINTSIGNOR | HINT:37737235HINT:38048360SIGNOR:31160049 | |
| GP174 | Q9BXC1 | GNAS2 | P63092 | Yes | Yes | HINTSIGNOR | HINT:37737235HINT:38048360SIGNOR:31160049 | |
| GP174 | Q9BXC1 | GNAS1 | Q5JWF2 | Yes | Yes | HINTSIGNOR | HINT:37737235HINT:38048360SIGNOR:31160049 | |
| GP174 | Q9BXC1 | GNAL | P38405 | Yes | Yes | SIGNOR | SIGNOR:31160049 | |
| GP174 | Q9BXC1 | GNA13 | Q14344 | Yes | Yes | SIGNOR | SIGNOR:31160049 |
Sequence, Structure & Domains
Sequences
Length
333
Mass
38,503
Sequence
MPANYTCTRPDGDNTDFRYFIYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVIFMINLAIADLLQVLSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYASIYFLVCISVRRFWFLMYPFRFHDCKQKYDLYISIAGWLIICLACVLFPLLRTSDDTSGNRTKCFVDLPTRNVNLAQSVVMMTIGELIGFVTPLLIVLYCTWKTVLSLQDKYPMAQDLGEKQKALKMILTCAGVFLICFAPYHFSFPLDFLVKSNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFSTNEFRRRLSRQDLHDSIQLHAKSFVSNHTASTMTPELC
3D Structural Models
Turn
16..18
Helix
19..48; 57..70; 73..81; 88..121; 123..126; 134..148; 151..154; 179..193; 195..211; 224..257; 264..281; 284..291
Beta Strand
128..130; 168..171; 219..221; 292..301
3D Structure
Electron microscopy (3)
Domain & Motif Annotations
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 38716512 | Assessment of urine sample collection and processing variables for extracellular vesicle-based proteomics. | No related sentences available |