Protein detail

TB10A

TBC1 domain family member 10A (EBP50-PDX interactor of 64 kDa) (EPI64 protein) (Rab27A-GAP-alpha)

Entry name
TB10A
UniProt ID
Q9BXI6
EVMP confidence score
0.38
Supporting publications (n)
6
Transmembrane count
Protein classification
Predicted intracellular proteins
Basic Information
Protein Names
TBC1 domain family member 10A (EBP50-PDX interactor of 64 kDa) (EPI64 protein) (Rab27A-GAP-alpha)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
ENSG00000099992
Entrez Gene Symbol
TBC1D10A
Gene Synonym (3)
AC004997.C22.2EPI64TBC1D10
Gene Description
TBC1 domain family member 10A
Chromosome
22
Position
30291990-30326947
Supporting publications (n)
6
EVMP confidence score
0.38
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (5)
Molecular Function (5)
Biological Process (3)
Reactome (4)
Canonical Pathways (3)
  • M23 Pid wnt noncanonical pathway
  • M108 Pid netrin pathway
  • M271 Pid pi3k plc trk pathway
Mediation Categories (2)
Fusion and delivery mediationMetabolism mediation
Relations & Evidence5

Ligand-Receptor Signaling (3)

3 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularComPPI
intracellularintracellularGO_Intercell
intracellularintracellularOmniPath

Protein Complex Composition (1)

1 record.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
ALDH5A1FGL1NAXDPPIL2TBC1D10AP51649Q08830Q13356Q8IW45Q9BXI60:0:0:0:0hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyMass spectrometry130646616
Sequence, Structure & Domains

Sequences

Length
508
Mass
57,118
Sequence
MAKSNGENGPRAPAAGESLSGTRESLAQGPDAATTDELSSLGSDSEANGFAERRIDKFGFIVGSQGAEGALEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKIRLRCQKGIPPSLRGRAWQYLSGGKVKLQQNPGKFDELDMSPGDPKWLDVIERDLHRQFPFHEMFVSRGGHGQQDLFRVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAEQAFWCLVQICEKYLPGYYSEKLEAIQLDGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWDMFFCEGVKIIFRVGLVLLKHALGSPEKVKACQGQYETIERLRSLSPKIMQEAFLVQEVVELPVTERQIEREHLIQLRRWQETRGELQCRSPPRLHGAKAILDAEPGPRPALQPSPSIRLPLDAPLPGSKAKPKPPKQAQKEQRKQMKGRGQLEKPPAPNQAMVVAAAGDACPPQHVPPKDSAPKDSAPQDLAPQVSAHHRSQESLTSQESEDTYL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BXI6-1; Sequence=Displayed; Name=2; IsoId=Q9BXI6-2; Sequence=VSP_043119
Alternative Sequence
70; A -> APCPLLHR (in isoform 2)

Domain & Motif Annotations

Compositional Bias
36..46; Polar residues
Domain (CC)
The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site.
Domain (FT)
111..299; Rab-GAP TBC
Region
1..46; Disordered; 396..508; Disordered; 505..508; Binding to the PDZ domain of EBP50
Clinical Relevance
Antibody (3)
HPA007725HPA008142HPA076041
Interaction Protein
ENSG00000109062
Interaction Count
1
Interaction Dataset
intact_biogrid
Supporting Publications6
PMIDTitleRelated sentences
32560723T2 and T17 cytokines alter the cargo and function of airway epithelium-derived extracellular vesicles.No related sentences available
33592500A Proteomic Approach to Understand the Clinical Significance of Acute Myeloid Leukemia-Derived Extracellular Vesicles Reflecting Essential Characteristics of Leukemia.No related sentences available
36146834Human Cytomegalovirus Modifies Placental Small Extracellular Vesicle Composition to Enhance Infection of Fetal Neural Cells In Vitro.No related sentences available
38113368In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.No related sentences available
38207106Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.No related sentences available
40189497Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis.No related sentences available