Protein detail
PRAX
Periaxin
Entry name PRAX | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Periaxin
Protein Class
Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins
Protein Function
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Disease related genes
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
KIAA1620
Gene Description
Periaxin
Chromosome
19
Position
40393766-40414793
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificbrainCell SpecificMelanocytesSingle-Nuclei Brain Specificchoroid plexus epithelial cell
Function & Pathway
Protein Function
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Disease related genes
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Predicted intracellular proteins
Cellular Component
Molecular Function
Reactome
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
6 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
6 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ProstaglandinF2a_byPRXL2B | PRXL2B | Q8TBF2 | 1 | CellPhoneDBCellChatDB | CellPhoneDB:ProstaglandinF2a_byPRXL2B | |
| CORTMRGPRX2 | O00230Q96LB1 | 1:1 | PDB | PDB:7vv4 | ||
| ADMMRGPRX2 | P35318Q96LB1 | 1:1 | PDB | PDB:7vv0 | ||
| NUCB1PRXL2B | Q02818Q8TBF2 | 0:0 | hu.MAPhu.MAP2 | |||
| CEP89ICA1ICA1LPICK1PRXL2C | Q05084Q7RTV5Q8NDH6Q96ST8Q9NRD5 | 0:0:0:0:0 | hu.MAP2 | |||
| PRX | Q9BXM0 | 3 | PDB | PDB:4cmz |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 40222457 |
Sequence, Structure & Domains
Sequences
Length
1,461
Mass
154,905
Sequence
MEARSRSAEELRRAELVEIIVETEAQTGVSGINVAGGGKEGIFVRELREDSPAARSLSLQEGDQLLSARVFFENFKYEDALRLLQCAEPYKVSFCLKRTVPTGDLALRPGTVSGYEIKGPRAKVAKLNIQSLSPVKKKKMVPGALGVPADLAPVDVEFSFPKFSRLRRGLKAEAVKGPVPAAPARRRLQLPRLRVREVAEEAQAARLAAAAPPPRKAKVEAEVAAGARFTAPQVELVGPRLPGAEVGVPQVSAPKAAPSAEAAGGFALHLPTLGLGAPAPPAVEAPAVGIQVPQVELPALPSLPTLPTLPCLETREGAVSVVVPTLDVAAPTVGVDLALPGAEVEARGEAPEVALKMPRLSFPRFGARAKEVAEAKVAKVSPEARVKGPRLRMPTFGLSLLEPRPAAPEVVESKLKLPTIKMPSLGIGVSGPEVKVPKGPEVKLPKAPEVKLPKVPEAALPEVRLPEVELPKVSEMKLPKVPEMAVPEVRLPEVELPKVSEMKLPKVPEMAVPEVRLPEVQLLKVSEMKLPKVPEMAVPEVRLPEVQLPKVSEMKLPEVSEVAVPEVRLPEVQLPKVPEMKVPEMKLPKVPEMKLPEMKLPEVQLPKVPEMAVPDVHLPEVQLPKVPEMKLPEMKLPEVKLPKVPEMAVPDVHLPEVQLPKVPEMKLPKMPEMAVPEVRLPEVQLPKVSEMKLPKVPEMAVPDVHLPEVQLPKVCEMKVPDMKLPEIKLPKVPEMAVPDVHLPEVQLPKVSEIRLPEMQVPKVPDVHLPKAPEVKLPRAPEVQLKATKAEQAEGMEFGFKMPKMTMPKLGRAESPSRGKPGEAGAEVSGKLVTLPCLQPEVDGEAHVGVPSLTLPSVELDLPGALGLQGQVPAAKMGKGERVEGPEVAAGVREVGFRVPSVEIVTPQLPAVEIEEGRLEMIETKVKPSSKFSLPKFGLSGPKVAKAEAEGAGRATKLKVSKFAISLPKARVGAEAEAKGAGEAGLLPALDLSIPQLSLDAHLPSGKVEVAGADLKFKGPRFALPKFGVRGRDTEAAELVPGVAELEGKGWGWDGRVKMPKLKMPSFGLARGKEAEVQGDRASPGEKAESTAVQLKIPEVELVTLGAQEEGRAEGAVAVSGMQLSGLKVSTAGQVVTEGHDAGLRMPPLGISLPQVELTGFGEAGTPGQQAQSTVPSAEGTAGYRVQVPQVTLSLPGAQVAGGELLVGEGVFKMPTVTVPQLELDVGLSREAQAGEAATGEGGLRLKLPTLGARARVGGEGAEEQPPGAERTFCLSLPDVELSPSGGNHAEYQVAEGEGEAGHKLKVRLPRFGLVRAKEGAEEGEKAKSPKLRLPRVGFSQSEMVTGEGSPSPEEEEEEEEEGSGEGASGRRGRVRVRLPRVGLAAPSKASRGQEGDAAPKSPVREKSPKFRFPRVSLSPKARSGSGDQEEGGLRVRLPSVGFSETGAPGPARMEGAQAAAV
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=L-periaxin; IsoId=Q9BXM0-1; Sequence=Displayed; Name=2; Synonyms=S-periaxin; IsoId=Q9BXM0-2; Sequence=VSP_004363, VSP_004364; Name=3; IsoId=Q9BXM0-3; Sequence=VSP_040352
Alternative Sequence
1..139; Missing (in isoform 3); 128..147; NIQSLSPVKKKKMVPGALGV -> VRVLSPAPALDCPSDPVSAP (in isoform 2); 148..1461; Missing (in isoform 2)
3D Structural Models
Helix
52..56; 77..87
Beta Strand
18..22; 26..28; 32..38; 41..47; 64..71; 90..99
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
1318..1327; Basic and acidic residues; 1352..1363; Acidic residues
Repeat
431..435; 1; 439..443; 2; 447..451; 3; 455..459; 4; 463..467; 5; 468..472; 6; 473..477; 7; 481..485; 8; 486..490; 9; 494..498; 10; 499..503; 11; 507..511; 12; 512..516; 13; 520..524; 14; 525..529; 15; 533..537; 16; 538..542; 17; 546..550; 18; 551..555; 19; 559..563; 20; 564..568; 21; 572..576; 22; 577..581; 23; 582..586; 24; 590..594; 25; 595..599; 26; 600..604; 27; 608..612; 28; 613..617; 29; 618..622; 30; 626..630; 31; 631..635; 32; 636..640; 33; 644..648; 34; 649..653; 35; 654..658; 36; 662..666; 37; 670..674; 38; 675..679; 39; 683..687; 40; 688..692; 41; 696..700; 42; 701..705; 43; 706..710; 44; 714..718; 45; 719..723; 46; 724..728; 47; 732..736; 48; 737..741; 49; 742..746; 50; 750..754; 51; 755..759; 52; 760..764; 53; 771..775; 54; 779..783; 55
Motif
70..84; Nuclear export signal; 118..196; Nuclear localization signal
Domain (CC)
Has a remarkable domain of repetitive pentameric units sometimes followed by a tripeptide spacer, it may separate two functional basic and acidic domains.; DOMAIN: The Arg/Lys-rich basic domain functions as a tripartite nuclear localization signal.; DOMAIN: The PDZ domain contains the signal for export from the nucleus (PubMed:24633211). The N-terminal region including the PDZ domain is required for the formation of Cajal bands on myelinated nerves.
Domain (FT)
16..99; PDZ
Region
431..783; 55 X 5 AA approximate tandem repeats of [LVMAG]-[PSREQC]-[EDKL]-[LIVMAP]-[AQKHRPE]; that may have a tripeptide spacer of [LV]-P-[KER]; 1318..1461; Disordered
Protein Families
Periaxin family
Sequence Similarities
Belongs to the periaxin family.
Clinical Relevance
Disease Involvement
Charcot-Marie-Tooth diseaseDejerine-Sottas syndromeDisease variantNeurodegenerationNeuropathy
Antibody