Protein detail

PRAX

Periaxin

Entry name PRAX	UniProt ID Q9BXM0	EVMP confidence score 0.40
Supporting publications (n) 1	Transmembrane count	Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

Basic Information

Protein Names

Periaxin

Protein Class (4)

Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

Protein Function (4)

Human disease related genes:Nervous system diseases:Neurodegenerative diseases
Disease related genes
Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
Predicted intracellular proteins

Ensembl

ENSG00000105227

Entrez Gene Symbol

PRX

Gene Synonym

KIAA1620

Gene Description

Periaxin

Chromosome

Position

40393766-40414793

Supporting publications (n)

EVMP confidence score

0.40

Fluorescence & Localization

Tissue SpecificbrainCell SpecificMelanocytesSingle-Nuclei Brain Specificchoroid plexus epithelial cell

Function & Pathway

Protein Function (4)

Human disease related genes:Nervous system diseases:Neurodegenerative diseases
Disease related genes
Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
Predicted intracellular proteins

Cellular Component (4)

Molecular Function (2)

Reactome (2)

Mediation Categories

Fusion and delivery mediation

Relations & Evidence13

Ligand-Receptor Signaling (6)

6 records.

Category	Parent	Database
intracellular	intracellular	ComPPI
intracellular	intracellular	GO_Intercell
intracellular	intracellular	UniProt_location
intracellular	intracellular	OmniPath
plasma_membrane	plasma_membrane	UniProt_location
plasma_membrane	plasma_membrane	OmniPath

Protein Complex Composition (6)

6 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
ProstaglandinF2a_byPRXL2B	PRXL2B	Q8TBF2	1	CellPhoneDBCellChatDB	CellPhoneDB:ProstaglandinF2a_byPRXL2B
	CORT MRGPRX2	O00230 Q96LB1	1:1	PDB	PDB:7vv4
	ADM MRGPRX2	P35318 Q96LB1	1:1	PDB	PDB:7vv0
	NUCB1 PRXL2B	Q02818 Q8TBF2	0:0	hu.MAPhu.MAP2
	CEP89 ICA1 ICA1L PICK1 PRXL2C	Q05084 Q7RTV5 Q8NDH6 Q96ST8 Q9NRD5	0:0:0:0:0	hu.MAP2
	PRX	Q9BXM0	3	PDB	PDB:4cmz

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	40222457

Sequence, Structure & Domains

Sequences

Length

1,461

Mass

154,905

Sequence

MEARSRSAEELRRAELVEIIVETEAQTGVSGINVAGGGKEGIFVRELREDSPAARSLSLQEGDQLLSARVFFENFKYEDALRLLQCAEPYKVSFCLKRTVPTGDLALRPGTVSGYEIKGPRAKVAKLNIQSLSPVKKKKMVPGALGVPADLAPVDVEFSFPKFSRLRRGLKAEAVKGPVPAAPARRRLQLPRLRVREVAEEAQAARLAAAAPPPRKAKVEAEVAAGARFTAPQVELVGPRLPGAEVGVPQVSAPKAAPSAEAAGGFALHLPTLGLGAPAPPAVEAPAVGIQVPQVELPALPSLPTLPTLPCLETREGAVSVVVPTLDVAAPTVGVDLALPGAEVEARGEAPEVALKMPRLSFPRFGARAKEVAEAKVAKVSPEARVKGPRLRMPTFGLSLLEPRPAAPEVVESKLKLPTIKMPSLGIGVSGPEVKVPKGPEVKLPKAPEVKLPKVPEAALPEVRLPEVELPKVSEMKLPKVPEMAVPEVRLPEVELPKVSEMKLPKVPEMAVPEVRLPEVQLLKVSEMKLPKVPEMAVPEVRLPEVQLPKVSEMKLPEVSEVAVPEVRLPEVQLPKVPEMKVPEMKLPKVPEMKLPEMKLPEVQLPKVPEMAVPDVHLPEVQLPKVPEMKLPEMKLPEVKLPKVPEMAVPDVHLPEVQLPKVPEMKLPKMPEMAVPEVRLPEVQLPKVSEMKLPKVPEMAVPDVHLPEVQLPKVCEMKVPDMKLPEIKLPKVPEMAVPDVHLPEVQLPKVSEIRLPEMQVPKVPDVHLPKAPEVKLPRAPEVQLKATKAEQAEGMEFGFKMPKMTMPKLGRAESPSRGKPGEAGAEVSGKLVTLPCLQPEVDGEAHVGVPSLTLPSVELDLPGALGLQGQVPAAKMGKGERVEGPEVAAGVREVGFRVPSVEIVTPQLPAVEIEEGRLEMIETKVKPSSKFSLPKFGLSGPKVAKAEAEGAGRATKLKVSKFAISLPKARVGAEAEAKGAGEAGLLPALDLSIPQLSLDAHLPSGKVEVAGADLKFKGPRFALPKFGVRGRDTEAAELVPGVAELEGKGWGWDGRVKMPKLKMPSFGLARGKEAEVQGDRASPGEKAESTAVQLKIPEVELVTLGAQEEGRAEGAVAVSGMQLSGLKVSTAGQVVTEGHDAGLRMPPLGISLPQVELTGFGEAGTPGQQAQSTVPSAEGTAGYRVQVPQVTLSLPGAQVAGGELLVGEGVFKMPTVTVPQLELDVGLSREAQAGEAATGEGGLRLKLPTLGARARVGGEGAEEQPPGAERTFCLSLPDVELSPSGGNHAEYQVAEGEGEAGHKLKVRLPRFGLVRAKEGAEEGEKAKSPKLRLPRVGFSQSEMVTGEGSPSPEEEEEEEEEGSGEGASGRRGRVRVRLPRVGLAAPSKASRGQEGDAAPKSPVREKSPKFRFPRVSLSPKARSGSGDQEEGGLRVRLPSVGFSETGAPGPARMEGAQAAAV

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=L-periaxin; IsoId=Q9BXM0-1; Sequence=Displayed; Name=2; Synonyms=S-periaxin; IsoId=Q9BXM0-2; Sequence=VSP_004363, VSP_004364; Name=3; IsoId=Q9BXM0-3; Sequence=VSP_040352

Alternative Sequence

1..139; Missing (in isoform 3); 128..147; NIQSLSPVKKKKMVPGALGV -> VRVLSPAPALDCPSDPVSAP (in isoform 2); 148..1461; Missing (in isoform 2)

3D Structural Models

Helix

52..56; 77..87

Beta Strand

18..22; 26..28; 32..38; 41..47; 64..71; 90..99

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

1318..1327; Basic and acidic residues; 1352..1363; Acidic residues

Repeat

431..435; 1; 439..443; 2; 447..451; 3; 455..459; 4; 463..467; 5; 468..472; 6; 473..477; 7; 481..485; 8; 486..490; 9; 494..498; 10; 499..503; 11; 507..511; 12; 512..516; 13; 520..524; 14; 525..529; 15; 533..537; 16; 538..542; 17; 546..550; 18; 551..555; 19; 559..563; 20; 564..568; 21; 572..576; 22; 577..581; 23; 582..586; 24; 590..594; 25; 595..599; 26; 600..604; 27; 608..612; 28; 613..617; 29; 618..622; 30; 626..630; 31; 631..635; 32; 636..640; 33; 644..648; 34; 649..653; 35; 654..658; 36; 662..666; 37; 670..674; 38; 675..679; 39; 683..687; 40; 688..692; 41; 696..700; 42; 701..705; 43; 706..710; 44; 714..718; 45; 719..723; 46; 724..728; 47; 732..736; 48; 737..741; 49; 742..746; 50; 750..754; 51; 755..759; 52; 760..764; 53; 771..775; 54; 779..783; 55

Motif

70..84; Nuclear export signal; 118..196; Nuclear localization signal

Domain (CC)

Has a remarkable domain of repetitive pentameric units sometimes followed by a tripeptide spacer, it may separate two functional basic and acidic domains.; DOMAIN: The Arg/Lys-rich basic domain functions as a tripartite nuclear localization signal.; DOMAIN: The PDZ domain contains the signal for export from the nucleus (PubMed:24633211). The N-terminal region including the PDZ domain is required for the formation of Cajal bands on myelinated nerves.

Domain (FT)

16..99; PDZ

Region

431..783; 55 X 5 AA approximate tandem repeats of [LVMAG]-[PSREQC]-[EDKL]-[LIVMAP]-[AQKHRPE]; that may have a tripeptide spacer of [LV]-P-[KER]; 1318..1461; Disordered

Protein Families

Periaxin family

Sequence Similarities

Belongs to the periaxin family.

Clinical Relevance

Disease Involvement (5)

Charcot-Marie-Tooth diseaseDejerine-Sottas syndromeDisease variantNeurodegenerationNeuropathy

Related Diseases (2)

Charcot-Marie-Tooth disease Dejerine-Sottas syndrome

Antibody

HPA001868

Supporting Publications1

PMID	Title	Related sentences
32795414	Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers.	Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers.