Protein detail

FSD1L

FSD1-like protein (Coiled-coil domain-containing protein 10) (FSD1 N-terminal-like protein)

Entry name FSD1L	UniProt ID Q9BXM9	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

FSD1-like protein (Coiled-coil domain-containing protein 10) (FSD1 N-terminal-like protein)

Protein Class (2)

Predicted intracellular proteinsPredicted membrane proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000106701

Entrez Gene Symbol

FSD1L

Gene Synonym (4)

CCDC10CSDUFD1FSD1CLFSD1NL

Gene Description

Fibronectin type III and SPRY domain containing 1 like

Chromosome

Position

105447796-105552433

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization5

Tissue SpecificbrainCell SpecificBrain excitatory neuronsBlood Cell Specificnaive CD4 T-cellBlood Lineage SpecificT-cells

Function & Pathway5

Protein Function

Predicted intracellular proteins

Cellular Component

GO:0005575 cellular_component

Molecular Function

GO:0003674 molecular_function

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence3

Ligand-Receptor Signaling (2)

2 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Size Exclusion Chromatography	Mass spectrometryWestern blotting	2	38731868 36362114

Sequence, Structure & Domains9

Sequences

Length

530

Mass

59,578

Sequence

MDSQKYCFKENENVTVDKACFLISNITIGPESINLQQEALQRIISTLANKNDEIQNFIDTLHHTLKGVQENSSNILSELDEEFDSLYSILDEVKESMINCIKQEQARKSQELQSQISQCNNALENSEELLEFATRSLDIKEPEEFSKAARQIKDRVTMASAFRLSLKPKVSDNMTHLMVDFSQERQMLQTLKFLPVPKAPEIDPVECLVADNSVTVAWRMPEEDNKIDHFILEHRKTNFDGLPRVKDERCWEIIDNIKGTEYTLSGLKFDSKYMNFRVRACNKAVAGEYSDPVTLETKALNFNLDNSSSHLNLKVEDTCVEWDPTGGKGQESKIKGKENKGRSGTPSPKRTSVGSRPPAVRGSRDRFTGESYTVLGDTAIESGQHYWEVKAQKDCKSYSVGVAYKTLGKFDQLGKTNTSWCIHVNNWLQNTFAAKHNNKVKALDVTVPEKIGVFCDFDGGQLSFYDANSKQLLYSFKTKFTQPVLPGFMVWCGGLSLSTGMQVPSAVRTLQKSENGMTGSASSLNNVVTQ

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9BXM9-1; Sequence=Displayed; Name=2; IsoId=Q9BXM9-2; Sequence=VSP_039645; Name=3; IsoId=Q9BXM9-3; Sequence=VSP_039645, VSP_039646, VSP_039647

Alternative Sequence

6..37; Missing (in isoform 2 and isoform 3); 148..177; AARQIKDRVTMASAFRLSLKPKVSDNMTHL -> VHKNCINTLNKGSCIFKKAFLFFFSFGFLY (in isoform 3); 178..530; Missing (in isoform 3)

Domain & Motif Annotations

Compositional Bias

330..341; Basic and acidic residues; 342..354; Polar residues

Coiled Coil

102..141

Domain (FT)

137..194; COS; 196..300; Fibronectin type-III; 300..506; B30.2/SPRY

Region

322..366; Disordered

Clinical Relevance1

Antibody

HPA035138

Supporting Publications1

PMID	Title	Abstract
38716512	Assessment of urine sample collection and processing variables for extracellular vesicle-based proteomics.	No abstract available