Protein detail

S26A6

Solute carrier family 26 member 6 (Anion exchange transporter) (Pendrin-like protein 1) (Pendrin-L1)

Entry name S26A6	UniProt ID Q9BXS9	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 8	Protein classification Metabolic proteinsPlasma proteinsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Solute carrier family 26 member 6 (Anion exchange transporter) (Pendrin-like protein 1) (Pendrin-L1)

Protein Class (4)

Metabolic proteinsPlasma proteinsPredicted membrane proteinsTransporters

Protein Function

Transporters:Electrochemical Potential-driven transporters

Transmembrane

116..136; Helical; 187..207; Helical; 264..284; Helical; 294..314; Helical; 348..368; Helical; 380..400; Helical; 417..437; Helical; 485..505; Helical

Transmembrane Count

Ensembl

ENSG00000225697

Entrez Gene Symbol

SLC26A6

Gene Synonym

DKFZp586E1422

Gene Description

Solute carrier family 26 member 6

Chromosome

Position

48625723-48635493

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization5

Tissue SpecificbrainCell SpecificAstrocytesSingle-Nuclei Brain Specificoligodendrocyte precursor cellBlood Cell Specificplasmacytoid DCBlood Lineage Specificdendritic cells

Function & Pathway8

Protein Function

Transporters:Electrochemical Potential-driven transporters

Cellular Component (12)

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Molecular Function (15)

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Biological Process (3)

KEGG (2)

Reactome (4)

Canonical Pathways (2)

M211 Pid hedgehog 2pathway
M219 Pid hedgehog gli pathway

Mediation Categories

Fusion and delivery mediation

Relations & Evidence31

Ligand-Receptor Signaling (29)

29 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
extracellular	extracellular	OmniPath	No	No	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transporter	transporter	Surfaceome	No	Yes	No	No	No
solute_carrier	transporter	Almen2009	No	Yes	No	No	No
apc	transporter	Surfaceome	No	Yes	No	No	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	SLC26A6	Q9BXS9	2	PDB	PDB:8opq

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Size Exclusion Chromatography	Western BlottingMass SpectrometryElisa	1	34771645

Sequence, Structure & Domains13

Sequences

Length

759

Mass

82,967

Sequence

MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARDAARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQAASPKGASVSINVNTSLEDMRSNNVEDCKMMQVSSGDKMEDATANGQEDSKAPDGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGHFFDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL

Alternative Products

Event=Alternative splicing; Named isoforms=7; Name=1; Synonyms=SLC26A6b; IsoId=Q9BXS9-1; Sequence=Displayed; Name=2; IsoId=Q9BXS9-2; Sequence=VSP_006169; Name=3; IsoId=Q9BXS9-3; Sequence=VSP_040127; Name=4; Synonyms=SLC26A6a; IsoId=Q9BXS9-4; Sequence=VSP_046807, VSP_040127; Name=5; Synonyms=SLC26A6c; IsoId=Q9BXS9-5; Sequence=VSP_046807, VSP_047851, VSP_040127; Name=6; Synonyms=SLC26A6d; IsoId=Q9BXS9-6; Sequence=VSP_046807, VSP_047852; Name=7; IsoId=Q9BXS9-7; Sequence=VSP_055273, VSP_055274

Alternative Sequence

1..21; Missing (in isoform 4, isoform 5 and isoform 6); 145..216; GTFAVMSVMVGSVTESLAPQALNDSMINETARDAARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVR -> ATPGPLPLLTAPGRPTGGAGPDPLRLRGHLPVRTSCPRLYHSCSCAGLRLTAQVCVWPPSEQPLWATVPHLL (in isoform 7); 217..252; Missing (in isoform 7); 264..301; Missing (in isoform 5); 602..631; ASPKGASVSINVNTSLEDMRSNNVEDCKMM -> GPLLSACLAPQ (in isoform 2); 632..759; QVSSGDKMEDATANGQEDSKAPDGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGHFFDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL -> VRLEVGKEVTAVSCRDAGSTCLMRNAMDPAAVGSRVLRRWQEEWGGWVRYSSGSVVICHRI (in isoform 6); 632; Missing (in isoform 3, isoform 4 and isoform 5)

3D Structural Models

Turn

287..290; 432..434; 528..530; 551..553

Helix

38..45; 64..74; 77..80; 86..115; 119..125; 128..136; 148..161; 171..200; 206..209; 212..235; 247..257; 259..261; 264..286; 297..312; 314..318; 338..340; 341..370; 376..392; 402..411; 416..431; 435..437; 442..451; 454..469; 471..486; 488..508; 554..564; 569..593; 658..661; 683..698; 710..718; 728..730; 735..744

Beta Strand

166..168; 291..293; 514..518; 525..527; 531..533; 540..544; 669..674; 702..706; 724..726; 731..734

3D Structure

Electron microscopy (1)

Domain & Motif Annotations

Domain (FT)

530..742; STAS

Region

636..657; Disordered

Protein Families

SLC26A/SulP transporter (TC 2.A.53) family

Sequence Similarities

Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.

Clinical Relevance1

Antibody (2)

HPA048363 HPA072381

Supporting Publications1

PMID	Title	Abstract
31805958	Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive impairment.	No abstract available