Protein detail
S26A6
Solute carrier family 26 member 6 (Anion exchange transporter) (Pendrin-like protein 1) (Pendrin-L1)
Entry name S26A6 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 8 | Protein classification Metabolic proteinsPlasma proteinsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Solute carrier family 26 member 6 (Anion exchange transporter) (Pendrin-like protein 1) (Pendrin-L1)
Protein Class
Metabolic proteinsPlasma proteinsPredicted membrane proteinsTransporters
Protein Function
Transporters:Electrochemical Potential-driven transporters
Transmembrane
116..136; Helical; 187..207; Helical; 264..284; Helical; 294..314; Helical; 348..368; Helical; 380..400; Helical; 417..437; Helical; 485..505; Helical
Transmembrane Count
8
Ensembl
Entrez Gene Symbol
Gene Synonym
DKFZp586E1422
Gene Description
Solute carrier family 26 member 6
Chromosome
3
Position
48625723-48635493
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificbrainCell SpecificAstrocytesSingle-Nuclei Brain Specificoligodendrocyte precursor cellBlood Cell Specificplasmacytoid DCBlood Lineage Specificdendritic cells
Function & Pathway
Protein Function
Transporters:Electrochemical Potential-driven transporters
Cellular Component
- GO:0005783 endoplasmic reticulum
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0012506 vesicle membrane
- GO:0016020 membrane
- GO:0016323 basolateral plasma membrane
- GO:0016324 apical plasma membrane
- GO:0030659 cytoplasmic vesicle membrane
- GO:0031526 brush border membrane
- GO:0031982 vesicle
- GO:0034707 chloride channel complex
- GO:0097225 sperm midpiece
Molecular Function
- GO:0005254 chloride channel activity
- GO:0005452 solute:inorganic anion antiporter activity
- GO:0005515 protein binding
- GO:0008271 secondary active sulfate transmembrane transporter activity
- GO:0015106 bicarbonate transmembrane transporter activity
- GO:0015108 chloride transmembrane transporter activity
- GO:0015116 sulfate transmembrane transporter activity
- GO:0015383 sulfate:bicarbonate antiporter activity
- GO:0015499 formate transmembrane transporter activity
- GO:0015562 efflux transmembrane transporter activity
- GO:0016740 transferase activity
- GO:0019531 oxalate transmembrane transporter activity
- GO:0030165 PDZ domain binding
- GO:0042802 identical protein binding
- GO:0140900 chloride:bicarbonate antiporter activity
Biological Process
Reactome
Canonical Pathways
- M211 Pid hedgehog 2pathway
- M219 Pid hedgehog gli pathway
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
29 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| apical_cell_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | No | No |
| cell_surface | cell_surface | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Western BlottingMass SpectrometryElisa | 1 | 34771645 |
Sequence, Structure & Domains
Sequences
Length
759
Mass
82,967
Sequence
MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARDAARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQAASPKGASVSINVNTSLEDMRSNNVEDCKMMQVSSGDKMEDATANGQEDSKAPDGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGHFFDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL
Alternative Products
Event=Alternative splicing; Named isoforms=7; Name=1; Synonyms=SLC26A6b; IsoId=Q9BXS9-1; Sequence=Displayed; Name=2; IsoId=Q9BXS9-2; Sequence=VSP_006169; Name=3; IsoId=Q9BXS9-3; Sequence=VSP_040127; Name=4; Synonyms=SLC26A6a; IsoId=Q9BXS9-4; Sequence=VSP_046807, VSP_040127; Name=5; Synonyms=SLC26A6c; IsoId=Q9BXS9-5; Sequence=VSP_046807, VSP_047851, VSP_040127; Name=6; Synonyms=SLC26A6d; IsoId=Q9BXS9-6; Sequence=VSP_046807, VSP_047852; Name=7; IsoId=Q9BXS9-7; Sequence=VSP_055273, VSP_055274
Alternative Sequence
1..21; Missing (in isoform 4, isoform 5 and isoform 6); 145..216; GTFAVMSVMVGSVTESLAPQALNDSMINETARDAARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVR -> ATPGPLPLLTAPGRPTGGAGPDPLRLRGHLPVRTSCPRLYHSCSCAGLRLTAQVCVWPPSEQPLWATVPHLL (in isoform 7); 217..252; Missing (in isoform 7); 264..301; Missing (in isoform 5); 602..631; ASPKGASVSINVNTSLEDMRSNNVEDCKMM -> GPLLSACLAPQ (in isoform 2); 632..759; QVSSGDKMEDATANGQEDSKAPDGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGHFFDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL -> VRLEVGKEVTAVSCRDAGSTCLMRNAMDPAAVGSRVLRRWQEEWGGWVRYSSGSVVICHRI (in isoform 6); 632; Missing (in isoform 3, isoform 4 and isoform 5)
3D Structural Models
Turn
287..290; 432..434; 528..530; 551..553
Helix
38..45; 64..74; 77..80; 86..115; 119..125; 128..136; 148..161; 171..200; 206..209; 212..235; 247..257; 259..261; 264..286; 297..312; 314..318; 338..340; 341..370; 376..392; 402..411; 416..431; 435..437; 442..451; 454..469; 471..486; 488..508; 554..564; 569..593; 658..661; 683..698; 710..718; 728..730; 735..744
Beta Strand
166..168; 291..293; 514..518; 525..527; 531..533; 540..544; 669..674; 702..706; 724..726; 731..734
3D Structure
Electron microscopy (1)
Domain & Motif Annotations
Domain (FT)
530..742; STAS
Region
636..657; Disordered
Protein Families
SLC26A/SulP transporter (TC 2.A.53) family
Sequence Similarities
Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.