Protein detail
CADM1
Cell adhesion molecule 1 (Immunoglobulin superfamily member 4) (IgSF4) (Nectin-like protein 2) (NECL-2) (Spermatogenic immunoglobulin superfamily) (SgIgSF) (Synaptic cell adhesion molecule) (SynCAM) (Tumor suppressor in lung cancer 1) (TSLC-1)
Entry name CADM1 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 3 | Transmembrane count 1 | Protein classification Human disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Cell adhesion molecule 1 (Immunoglobulin superfamily member 4) (IgSF4) (Nectin-like protein 2) (NECL-2) (Spermatogenic immunoglobulin superfamily) (SgIgSF) (Synaptic cell adhesion molecule) (SynCAM) (Tumor suppressor in lung cancer 1) (TSLC-1)
Protein Class (4)
Human disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function (2)
- Human disease related genes:Cancers:Head and neck cancers
- Predicted intracellular proteins
Transmembrane
375..395; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (10)
BL2IGSF4IGSF4ANecl-2NECL2RA175ST17SYNCAMSYNCAM1TSLC1
Gene Description
Cell adhesion molecule 1
Chromosome
11
Position
115169218-115504957
Supporting publications (n)
3
EVMP confidence score
0.50
Fluorescence & Localization3
Tissue SpecificbrainCell SpecificAlveolar cells type 1
Function & Pathway7
Protein Function (2)
- Human disease related genes:Cancers:Head and neck cancers
- Predicted intracellular proteins
Cellular Component (7)
Molecular Function (5)
Biological Process (3)
Reactome (4)
Mediation Categories (3)
Adhesion and uptake mediationImmune mediationReceptor-signaling mediation
Relations & Evidence42
Ligand-Receptor Signaling (40)
40 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | connectomeDB2020 | Yes | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | CellChatDB | Yes | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | Baccin2019 | Yes | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | CellPhoneDB | Yes | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | OmniPath | Yes | No | No | Yes | No |
| nectin | cell_adhesion | HGNC | Yes | Yes | No | Yes | No |
| adhesion | adhesion | HGNC | Yes | Yes | No | Yes | No |
| adhesion | adhesion | MCAM | Yes | Yes | No | Yes | No |
| ig_like | adhesion | Almen2009 | Yes | Yes | No | Yes | No |
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Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Western BlottingMass SpectrometryElisa | 1 | 34771645 |
Sequence, Structure & Domains12
Sequences
Length
442
Mass
48,509
Sequence
MASVVLPSGSQCAAAAAAAAPPGLRLRLLLLLFSAAALIPTGDGQNLFTKDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTTTTTTILTIITDSRAGEEGSIRAVDHAVIGGVVAVVVFAMLCLLIILGRYFARHKGTYFTHEAKGADDAADADTAIINAEGGQNNSEEKKEYFI
Alternative Products
Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q9BY67-1; Sequence=Displayed; Name=2; IsoId=Q9BY67-2; Sequence=VSP_052461, VSP_052462; Name=3; IsoId=Q9BY67-3; Sequence=VSP_047406; Name=4; IsoId=Q9BY67-4; Sequence=VSP_047407; Name=5; Synonyms=E; IsoId=Q9BY67-5; Sequence=VSP_047405
Alternative Sequence
332..333; DP -> GT (in isoform 2); 333..360; Missing (in isoform 5); 334..442; Missing (in isoform 2); 359; T -> TDTTATTEPAVHGLTQLPNSAEELDSEDLS (in isoform 3); 359; T -> TDTTATTEPAVH (in isoform 4)
3D Structural Models
Helix
116..118
Beta Strand
52..55; 60..68; 74..77; 83..86; 97..103; 106..113; 120..126; 128..130; 132..141; 405..407
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Domain (CC)
The cytoplasmic domain appears to play a critical role in proapoptosis and tumor suppressor activity in NSCLC.
Domain (FT)
45..139; Ig-like V-type; 144..238; Ig-like C2-type 1; 243..329; Ig-like C2-type 2
Protein Families
Nectin family
Sequence Similarities
Belongs to the nectin family.
Clinical Relevance2
Disease Involvement
Tumor suppressor
Antibody
Supporting Publications3
| PMID | Title | Abstract |
|---|---|---|
| 37922300 | Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women. | No abstract available |
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No abstract available |
| 40098346 | Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays. | No abstract available |