Protein detail
CADM1
Cell adhesion molecule 1 (Immunoglobulin superfamily member 4) (IgSF4) (Nectin-like protein 2) (NECL-2) (Spermatogenic immunoglobulin superfamily) (SgIgSF) (Synaptic cell adhesion molecule) (SynCAM) (Tumor suppressor in lung cancer 1) (TSLC-1)
Protein symbol CADM1 | UniProt ID | EVMP score 0.50 |
Frequency 3 | Transmembrane count 1 | Protein classification Human disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
Basic Information
Protein Names
Cell adhesion molecule 1 (Immunoglobulin superfamily member 4) (IgSF4) (Nectin-like protein 2) (NECL-2) (Spermatogenic immunoglobulin superfamily) (SgIgSF) (Synaptic cell adhesion molecule) (SynCAM) (Tumor suppressor in lung cancer 1) (TSLC-1)
Protein Class
Human disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Human disease related genes:Cancers:Head and neck cancers
- Predicted intracellular proteins
Transmembrane
375..395; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
BL2IGSF4IGSF4ANecl-2NECL2RA175ST17SYNCAMSYNCAM1TSLC1
Gene Description
Cell adhesion molecule 1
Chromosome
11
Position
115169218-115504957
Frequency
3
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificbrainCell SpecificAlveolar cells type 1
Function & Pathway
Protein Function
- Human disease related genes:Cancers:Head and neck cancers
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Adhesion and uptake mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
40 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | CellPhoneDB | No | No | No | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Western BlottingMass SpectrometryElisa | 1 | 34771645 |
Sequence, Structure & Domains
Sequences
Length
442
Mass
48,509
Sequence
MASVVLPSGSQCAAAAAAAAPPGLRLRLLLLLFSAAALIPTGDGQNLFTKDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTTTTTTILTIITDSRAGEEGSIRAVDHAVIGGVVAVVVFAMLCLLIILGRYFARHKGTYFTHEAKGADDAADADTAIINAEGGQNNSEEKKEYFI
Alternative Products
Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q9BY67-1; Sequence=Displayed; Name=2; IsoId=Q9BY67-2; Sequence=VSP_052461, VSP_052462; Name=3; IsoId=Q9BY67-3; Sequence=VSP_047406; Name=4; IsoId=Q9BY67-4; Sequence=VSP_047407; Name=5; Synonyms=E; IsoId=Q9BY67-5; Sequence=VSP_047405
Alternative Sequence
332..333; DP -> GT (in isoform 2); 333..360; Missing (in isoform 5); 334..442; Missing (in isoform 2); 359; T -> TDTTATTEPAVHGLTQLPNSAEELDSEDLS (in isoform 3); 359; T -> TDTTATTEPAVH (in isoform 4)
3D Structural Models
Helix
116..118
Beta Strand
52..55; 60..68; 74..77; 83..86; 97..103; 106..113; 120..126; 128..130; 132..141; 405..407
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Domain (CC)
The cytoplasmic domain appears to play a critical role in proapoptosis and tumor suppressor activity in NSCLC.
Domain (FT)
45..139; Ig-like V-type; 144..238; Ig-like C2-type 1; 243..329; Ig-like C2-type 2
Protein Families
Nectin family
Sequence Similarities
Belongs to the nectin family.
Clinical Relevance
Disease Involvement
Tumor suppressor
Antibody