Protein detail

TMPSD

Transmembrane protease serine 13 (EC 3.4.21.-) (Membrane-type mosaic serine protease) (Mosaic serine protease)

Entry name TMPSD	UniProt ID Q9BYE2	EVMP score 0.50
Frequency 1	Transmembrane count 1	Protein classification

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Transmembrane protease serine 13 (EC 3.4.21.-) (Membrane-type mosaic serine protease) (Mosaic serine protease)

Protein Function

Predicted intracellular proteins
Peptidases:Serine-type peptidases
Enzymes
Predicted secreted proteins
Transporters:Accessory Factors Involved in Transport

Transmembrane

166..186; Helical; Signal-anchor for type II membrane protein

Transmembrane Count

Ensembl

ENSG00000137747

Entrez Gene Symbol

TMPRSS13

Frequency

EVMP Score

0.50

Fluorescence & Localization

Secretome LocationIntracellular and membraneSecretome FunctionNo annotated function

Function & Pathway

Protein Function

Predicted intracellular proteins
Peptidases:Serine-type peptidases
Enzymes
Predicted secreted proteins
Transporters:Accessory Factors Involved in Transport

Cellular Component

Molecular Function

GO:0004252 serine-type endopeptidase activity

Biological Process

Mediation Categories

Other mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

25 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
secreted	secreted	UniProt_location	No	No	Yes	No	No
secreted	secreted	OmniPath	No	No	Yes	No	No
cell_surface	cell_surface	Surfaceome	No	No	Yes	No	No
cell_surface	cell_surface	OmniPath	No	No	Yes	No	No
transmembrane	transmembrane_predicted	Phobius	No	No	Yes	No	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	TMPRSS13	Q9BYE2	2	PDB	PDB:6kd5

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometryWestern blotting	5	39290459 30805606 38731868 30550287 40098346

Sequence, Structure & Domains

Sequences

Length

586

Mass

63,167

Sequence

MERDSHGNASPARTPSAGASPAQASPAGTPPGRASPAQASPAQASPAGTPPGRASPAQASPAGTPPGRASPGRASPAQASPAQASPARASPALASLSRSSSGRSSSARSASVTTSPTRVYLVRATPVGAVPIRSSPARSAPATRATRESPGTSLPKFTWREGQKQLPLIGCVLLLIALVVSLIILFQFWQGHTGIRYKEQRESCPKHAVRCDGVVDCKLKSDELGCVRFDWDKSLLKIYSGSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAHRDFANSFSILRYNSTIQESLHRSECPSQRYISLQCSHCGLRAMTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEGWKVYAGTSNLHQLPEAASIAEIIINSNYTDEEDDYDIALMRLSKPLTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWIYSKMEVRSLQQDTAPSRLGTSSGGDPGGAPRL

Alternative Products

Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=MSPL; IsoId=Q9BYE2-1; Sequence=Displayed; Name=2; IsoId=Q9BYE2-2; Sequence=VSP_013103, VSP_013104; Name=3; Synonyms=MSPS; IsoId=Q9BYE2-3; Sequence=VSP_013099, VSP_013102; Name=4; IsoId=Q9BYE2-4; Sequence=VSP_013100, VSP_013101; Name=6; IsoId=Q9BYE2-6; Sequence=VSP_013102

Alternative Sequence

151..186; GTSLPKFTWREGQKQLPLIGCVLLLIALVVSLIILF -> V (in isoform 3); 428..491; AHIHPACLPMHGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDSYLT -> GEGICTPRSPAPQPQHPLQPSHLSASVNSYPGPKASAGQKSKTLKDPYMEHFCFIIRETEAQGL (in isoform 4); 492..586; Missing (in isoform 4); 560..586; VRSLQQDTAPSRLGTSSGGDPGGAPRL -> SEVRFRKS (in isoform 3 and isoform 6); 560..563; VRSL -> SSAG (in isoform 2); 564..586; Missing (in isoform 2)

3D Structural Models

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

14..52; Low complexity; 69..111; Low complexity; 133..144; Low complexity; 565..574; Polar residues; 575..586; Gly residues

Repeat

9..13; 1-1; 14..18; 2-1; approximate; 19..23; 1-2; 24..28; 1-3; 29..33; 2-2; 34..38; 1-4; 39..43; 1-5; 44..48; 1-6; 49..53; 2-3; 54..58; 1-7; 59..63; 1-8; 64..68; 2-4; 69..78; 1-9; approximate; 79..83; 1-10; 84..88; 1-11; 89..93; 1-12

Domain (FT)

195..325; SRCR; 204..226; LDL-receptor class A; 326..559; Peptidase S1

Region

1..115; Disordered; 9..93; 13 X 5 AA repeats of A-S-P-A-[GLQR]; 14..68; 4 X 5 AA repeats of T-P-P-G-R; 131..157; Disordered; 565..586; Disordered

Protein Families

Peptidase S1 family

Sequence Similarities

Belongs to the peptidase S1 family.

Clinical Relevance