Protein detail
CDHR2
Cadherin-related family member 2 (Protocadherin LKC) (PC-LKC) (Protocadherin-24)
Entry name CDHR2 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) | Transmembrane count 1 | Protein classification Plasma proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Cadherin-related family member 2 (Protocadherin LKC) (PC-LKC) (Protocadherin-24)
Protein Class (2)
Plasma proteinsPredicted membrane proteins
Transmembrane
1155..1175; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (5)
FLJ20124FLJ20383PC-LKCPCDH24PCLKC
Gene Description
Cadherin related family member 2
Chromosome
5
Position
176542511-176595974
EVMP confidence score
0.38
Fluorescence & Localization4
Tissue SpecificintestineCell SpecificBreast lactating cellsSingle-Nuclei Brain Specificendothelial cellBlood Cell SpecificMAIT T-cell
Function & Pathway4
Cellular Component (8)
Molecular Function (3)
Biological Process (3)
Mediation Categories (2)
Adhesion and uptake mediationFusion and delivery mediation
Relations & Evidence36
Ligand-Receptor Signaling (34)
34 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | Yes | No |
| apical_cell_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| apical_cell_membrane | plasma_membrane | Ramilowski_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | Ramilowski_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Western BlottingMass SpectrometryElisa | 1 | 34771645 |
Sequence, Structure & Domains11
Sequences
Length
1,310
Mass
141,543
Sequence
MAQLWLSCFLLPALVVSVAANVAPKFLANMTSVILPEDLPVGAQAFWLVAEDQDNDPLTYGMSGPNAYFFAVTPKTGEVKLASALDYETLYTFKVTISVSDPYIQVQREMLVIVEDRNDNAPVFQNTAFSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGADGVIRVNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAVGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLRDINDHRPTFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQATDGGNLSSSTTLQIHLLDINDNAPVVSGSYNIFVQEEEGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEEDPGVLVGVVKAWDADQTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREVASVRARDDDSGNNGVILFSILRVDFISKDGATIPFQGVFSIFTSSEADVFAGSIQPVTSLDSTLQGTYQVTVQARDRPSLGPFLEATTTLNLFTVDQSYRSRLQFSTPKEEVGANRQAINAALTQATRTTVYIVDIQDIDSAARARPHSYLDAYFVFPNGSALTLDELSVMIRNDQDSLTQLLQLGLVVLGSQESQESDLSKQLISVIIGLGVALLLVLVIMTMAFVCVRKSYNRKLQAMKAAKEARKTAAGVMPSAPAIPGTNMYNTERANPMLNLPNKDLGLEYLSPSNDLDSVSVNSLDDNSVDVDKNSQEIKEHRPPHTPPEPDPEPLSVVLLGRQAGASGQLEGPSYTNAGLDTTDL
3D Structural Models
Turn
74..76; 87..89; 193..196
Helix
28..31; 67..69; 154..157; 173..175
Beta Strand
32..36; 43..47; 59..64; 70..72; 78..81; 91..100; 105..115; 123..125; 130..134; 142..145; 159..168; 170..172; 176..179; 183..187; 198..208; 211..213; 216..218; 225..232
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
1259..1268; Basic and acidic residues; 1299..1310; Polar residues
Domain (CC)
The cadherin 1 domain is required for binding to CDHR5..
Domain (FT)
27..124; Cadherin 1; 125..241; Cadherin 2; 242..353; Cadherin 3; 368..480; Cadherin 4; 481..586; Cadherin 5; 586..695; Cadherin 6; 696..808; Cadherin 7; 810..928; Cadherin 8; 930..1058; Cadherin 9
Region
1180..1310; Mediates interaction with USH1C and MYO7B and is required for proper localization to microvilli tips and function in microvilli organization; 1259..1310; Disordered