Protein detail

PAR6B

Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B)

Entry name PAR6B	UniProt ID Q9BYG5	EVMP confidence score 0.38
Supporting publications (n) 2	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000124171

Entrez Gene Symbol

PARD6B

Gene Synonym

PAR-6B

Gene Description

Par-6 family cell polarity regulator beta

Chromosome

Position

50731580-50756795

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization4

Cell SpecificBasal prostatic cellsSingle-Nuclei Brain Specificmidbrain-derived inhibitoryBlood Cell Specificintermediate monocyteBlood Lineage Specificmonocytes

Function & Pathway7

Protein Function

Predicted intracellular proteins

Cellular Component (9)

Molecular Function

GO:0005515 protein binding

Biological Process (3)

KEGG (7)

Reactome (6)

Mediation Categories (2)

Fusion and delivery mediationReceptor-signaling mediation

Relations & Evidence17

Enzyme-Mediated Modification (1)

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
PARD6B	PAK4	O96013	S	143	phosphorylation	RLIMS-P_ProtMapperREACH_ProtMapperProtMapper	ProtMapper:25662318

Ligand-Receptor Signaling (9)

9 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
tight_junction	tight_junction	GO_Intercell	Yes	Yes	No	No	No
tight_junction	tight_junction	OmniPath	Yes	Yes	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Protein Complex Composition (6)

6 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
LLGL1-PAR-6B-PRKCI complex	LLGL1 PARD6B PRKCI	P41743 Q15334 Q9BYG5	1:1:1	CompleatCORUM	CORUM:959Compleat:HC984	12725730
LLGL2-PAR-6B-PRKCI complex	LLGL2 PARD6B PRKCI	P41743 Q6P1M3 Q9BYG5	1:1:1	CompleatCORUM	Compleat:HC2615CORUM:955	12725730
PAR6-CDC42 complex	CDC42 PARD6B	P60953 Q9BYG5	1:1	CompleatCORUM	Compleat:HC2724CORUM:5558	12606577
	PARD6B PRKCI PRKCZ	P41743 Q05513 Q9BYG5	0:0:0	hu.MAP2
	PARD6B PRKCZ PTPN14 PTPN21	Q05513 Q15678 Q16825 Q9BYG5	0:0:0:0	hu.MAP
	PARD6B PRKCZ PTPN21 WWC1	Q05513 Q16825 Q8IX03 Q9BYG5	0:0:0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometryR Sequencing	4	34815502 31382537 27821849 38716512

Sequence, Structure & Domains11

Sequences

Length

372

Mass

41,182

Sequence

MNRSHRHGAGSGCLGTMEVKSKFGAEFRRFSLERSKPGKFEEFYGLLQHVHKIPNVDVLVGYADIHGDLLPINNDDNYHKAVSTANPLLRIFIQKKEEADYSAFGTDTLIKKKNVLTNVLRPDNHRKKPHIVISMPQDFRPVSSIIDVDILPETHRRVRLYKYGTEKPLGFYIRDGSSVRVTPHGLEKVPGIFISRLVPGGLAQSTGLLAVNDEVLEVNGIEVSGKSLDQVTDMMIANSRNLIITVRPANQRNNVVRNSRTSGSSGQSTDNSLLGYPQQIEPSFEPEDEDSEEDDIIIEDNGVPQQIPKAVPNTESLESLTQIELSFESGQNGFIPSNEVSLAAIASSSNTEFETHAPDQKLLEEDGTIITL

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BYG5-1; Sequence=Displayed; Name=2; IsoId=Q9BYG5-2; Sequence=VSP_053311, VSP_053312

Alternative Sequence

97..113; EEADYSAFGTDTLIKKK -> GCVLEHSKNNVRMPCLK (in isoform 2); 114..370; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

253..272; Polar residues

Domain (CC)

The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.; DOMAIN: The PDZ domain mediates interaction with PALS1..

Domain (FT)

16..96; PB1; 133..150; Pseudo-CRIB; 157..250; PDZ

Region

126..253; Interaction with PARD3 and CDC42; 253..292; Disordered

Protein Families

PAR6 family

Sequence Similarities

Belongs to the PAR6 family.

Clinical Relevance4

Antibody (2)

HPA013376 HPA013708

Interaction Protein (12)

ENSG00000067606ENSG00000070831ENSG00000073350ENSG00000108953ENSG00000119729ENSG00000126785ENSG00000128245ENSG00000131899ENSG00000136238ENSG00000148498ENSG00000163558ENSG00000178184

Interaction Count

Interaction Dataset (5)

intact_biogrid_bioplexintact_biogridbiogrid_opencellbiogrid_bioplexintact_biogrid_opencell_bioplex

Supporting Publications2

PMID	Title	Abstract
26775013	Proteomic characterization of circulating extracellular vesicles identifies novel serum myeloma associated markers.	No abstract available
40098346	Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays.	No abstract available