Protein detail
HYCCI
Hyccin (Down-regulated by CTNNB1 protein A)
Protein symbol HYCCI | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Hyccin (Down-regulated by CTNNB1 protein A)
Protein Class
Disease related genesHuman disease related genesPredicted intracellular proteins
Protein Function
- Disease related genes
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
DRCTNNB1AFAM126AHCChyccin
Gene Description
Hyccin PI4KA lipid kinase complex subunit 1
Chromosome
7
Position
22889371-23014130
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificOcular epithelial cells
Function & Pathway
Protein Function
- Disease related genes
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Metabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
10 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane | LOCATE | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 37163338 |
Sequence, Structure & Domains
Sequences
Length
521
Mass
57,625
Sequence
MFTSEKGVVEEWLSEFKTLPETSLPNYATNLKDKSSLVSSLYKVIQEPQSELLEPVCHQLFEFYRSGEEQLLQFTLQFLPELIWCYLAVSASRNVHSSGCIEALLLGVYNLEIVDKQGHTKVLSFTIPSLSKPSVYHEPSSIGSMALTESALSQHGLSKVVYSGPHPQREMLTAQNRFEVLTFLLLCYNAALTYMPSVSLQSLCQICSRICVCGYPRQHVRKYKGISSRIPVSSGFMVQMLTGIYFAFYNGEWDLAQKALDDIIYRAQLELYPEPLLVANAIKASLPHGPMKSNKEGTRCIQVEITPTSSRISRNAVTSMSIRGHRWKRHGNTELTGQEELMEISEVDEGFYSRAASSTSQSGLSNSSHNCSNKPSIGKNHRRSGGSKTGGKEKETTGESCKDHFARKQTQRAQSENLELLSLKRLTLTTSQSLPKPSSHGLAKTAATVFSKSFEQVSGVTVPHNPSSAVGCGAGTDANRFSACSLQEEKLIYVSERTELPMKHQSGQQRPPSISITLSTD
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9BYI3-1; Sequence=Displayed; Name=2; IsoId=Q9BYI3-2; Sequence=VSP_023126; Name=3; IsoId=Q9BYI3-3; Sequence=VSP_058128, VSP_058129
Alternative Sequence
1..341; Missing (in isoform 2); 331..419; GNTELTGQEELMEISEVDEGFYSRAASSTSQSGLSNSSHNCSNKPSIGKNHRRSGGSKTGGKEKETTGESCKDHFARKQTQRAQSENLE -> EQPDNNNDATELGILVIPEISVTNVAGERTGNGEKGRTLGEIDAQHIQGVQETATDPRTESKGLPEIRRQKSVRKMMEDGINSPGRVQF (in isoform 3); 420..521; Missing (in isoform 3)
3D Structural Models
Turn
26..28; 249..251
Helix
8..14; 37..46; 54..65; 69..76; 79..91; 100..112; 144..147; 176..190; 197..212; 217..221; 234..248; 253..269; 273..285
Beta Strand
116..119; 123..126; 130..132; 159..163
3D Structure
Electron microscopy (3); X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
355..373; Low complexity; 390..406; Basic and acidic residues; 505..521; Polar residues
Region
355..413; Disordered; 501..521; Disordered
Protein Families
Hyccin family
Sequence Similarities
Belongs to the Hyccin family.
Clinical Relevance
Disease Involvement
CataractDisease variantLeukodystrophy
Antibody
Interaction Protein
ENSG00000165914ENSG00000241973
Interaction Count
2
Interaction Dataset
intact_biogridbiogrid_opencell