Protein detail
LOXE3
Hydroperoxide isomerase ALOXE3 (Epidermis-type lipoxygenase 3) (Epidermal LOX-3) (e-LOX-3) (eLOX-3) (Hydroperoxy dehydratase ALOXE3) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152) (Hydroperoxy icosatetraenoate isomerase) (EC 5.4.4.7)
Entry name LOXE3 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Hydroperoxide isomerase ALOXE3 (Epidermis-type lipoxygenase 3) (Epidermal LOX-3) (e-LOX-3) (eLOX-3) (Hydroperoxy dehydratase ALOXE3) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152) (Hydroperoxy icosatetraenoate isomerase) (EC 5.4.4.7)
Protein Class (6)
Disease related genesEnzymesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteins
Protein Function (7)
- ENZYME proteins:Isomerase
- Predicted intracellular proteins
- ENZYME proteins:Lyases
- Potential drug targets
- Enzymes
- Human disease related genes:Congenital malformations:Congenital malformations of skin
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
E-LOXeLOX3
Gene Description
Arachidonate lipoxygenase 3
Chromosome
17
Position
8095900-8119047
Supporting publications (n)
1
EVMP confidence score
0.38
Function & Pathway8
Protein Function (7)
- ENZYME proteins:Isomerase
- Predicted intracellular proteins
- ENZYME proteins:Lyases
- Potential drug targets
- Enzymes
- Human disease related genes:Congenital malformations:Congenital malformations of skin
- Disease related genes
Cellular Component
Molecular Function (7)
- GO:0005506 iron ion binding
- GO:0005515 protein binding
- GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
- GO:0050486 intramolecular hydroxytransferase activity
- GO:0051120 hepoxilin A3 synthase activity
- GO:0106255 hydroperoxy icosatetraenoate isomerase activity
- GO:0106256 hydroperoxy icosatetraenoate dehydratase activity
Biological Process (3)
KEGG (3)
Reactome (4)
Canonical Pathways (2)
- M185 Pid alk1 pathway
- M255 Pid hif1 tfpathway
Mediation Categories
Metabolism mediation
Relations & Evidence9
Ligand-Receptor Signaling (6)
6 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
Protein Complex Composition (2)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry；Western blotting；RNA Sequencing；Immunofluorescence | 1 | 40689422 |
Sequence, Structure & Domains9
Sequences
Length
711
Mass
80,543
Sequence
MAVYRLCVTTGPYLRAGTLDNISVTLVGTCGESPKQRLDRMGRDFAPGSVQKYKVRCTAELGELLLLRVHKERYAFFRKDSWYCSRICVTEPDGSVSHFPCYQWIEGYCTVELRPGTARTICQDSLPLLLDHRTRELRARQECYRWKIYAPGFPCMVDVNSFQEMESDKKFALTKTTTCVDQGDSSGNRYLPGFPMKIDIPSLMYMEPNVRYSATKTISLLFNAIPASLGMKLRGLLDRKGSWKKLDDMQNIFWCHKTFTTKYVTEHWCEDHFFGYQYLNGVNPVMLHCISSLPSKLPVTNDMVAPLLGQDTCLQTELERGNIFLADYWILAEAPTHCLNGRQQYVAAPLCLLWLSPQGALVPLAIQLSQTPGPDSPIFLPTDSEWDWLLAKTWVRNSEFLVHENNTHFLCTHLLCEAFAMATLRQLPLCHPIYKLLLPHTRYTLQVNTIARATLLNPEGLVDQVTSIGRQGLIYLMSTGLAHFTYTNFCLPDSLRARGVLAIPNYHYRDDGLKIWAAIESFVSEIVGYYYPSDASVQQDSELQAWTGEIFAQAFLGRESSGFPSRLCTPGEMVKFLTAIIFNCSAQHAAVNSGQHDFGAWMPNAPSSMRQPPPQTKGTTTLKTYLDTLPEVNISCNNLLLFWLVSQEPKDQRPLGTYPDEHFTEEAPRRSIAAFQSRLAQISRDIQERNQGLALPYTYLDPPLIENSVSI
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BYJ1-1; Sequence=Displayed; Name=2; IsoId=Q9BYJ1-2; Sequence=VSP_043287
Alternative Sequence
1; M -> MPRGAFRPCLPALYFAFLTCPTPEQRMSGTQAPDIHLGEPARGTGCVRGKQTSIRVQDCGRREEARAASRELRREKAQEHPRESWAHPQPYPAPQPLALRPETQPCPACRSSPPGRLLLRPALPGHPFLLPIM (in isoform 2)
3D Structural Models
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Domain (FT)
2..119; PLAT; 120..711; Lipoxygenase
Protein Families
Lipoxygenase family
Sequence Similarities
Belongs to the lipoxygenase family.
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 32230970 | Radiation Exposure of Peripheral Mononuclear Blood Cells Alters the Composition and Function of Secreted Extracellular Vesicles. | No abstract available |