Protein detail

TRI54

Tripartite motif-containing protein 54 (Muscle-specific RING finger protein) (MuRF) (Muscle-specific RING finger protein 3) (MuRF-3) (MuRF3) (RING finger protein 30)

Entry name TRI54	UniProt ID Q9BYV2	EVMP score 0.38
Frequency 3	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Tripartite motif-containing protein 54 (Muscle-specific RING finger protein) (MuRF) (Muscle-specific RING finger protein 3) (MuRF-3) (MuRF3) (RING finger protein 30)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000138100

Entrez Gene Symbol

TRIM54

Gene Synonym

MURFMURF-3RNF30

Gene Description

Tripartite motif containing 54

Chromosome

Position

27282429-27307439

Frequency

EVMP Score

0.38

Fluorescence & Localization

Cell SpecificEsophageal apical cells

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

KEGG

hsa04820 Cytoskeleton in muscle cells

Mediation Categories

Immune mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network

136 records.

Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
COMPLEX:P0CG47_Q96LR5	TRI54	Q9BYV2	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P62987_Q9H832	TRI54	Q9BYV2	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P62979_P68036	TRI54	Q9BYV2	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P62987_P63146	TRI54	Q9BYV2	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:O14933_P0CG47	TRI54	Q9BYV2	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P0CG48_P62256	TRI54	Q9BYV2	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P0CG47_Q8N2K1	TRI54	Q9BYV2	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:O14933_P62979	TRI54	Q9BYV2	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P0CG47_Q9Y2X8	TRI54	Q9BYV2	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P61086_P62979	TRI54	Q9BYV2	Yes	Yes	No	SIGNOR	SIGNOR:34199813

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Protein Complex Composition

5 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
Ub:RING_E3	TRIM54 UBB	P0CG47 Q9BYV2	0:0	SIGNOR	SIGNOR:SIGNOR-C519
Ub:RING_E3	TRIM54 UBC	P0CG48 Q9BYV2	0:0	SIGNOR	SIGNOR:SIGNOR-C519
Ub:RING_E3	RPS27A TRIM54	P62979 Q9BYV2	0:0	SIGNOR	SIGNOR:SIGNOR-C519
Ub:RING_E3	TRIM54 UBA52	P62987 Q9BYV2	0:0	SIGNOR	SIGNOR:SIGNOR-C519
	CKM TRIM54 TRIM55 TRIM63 USP13	P06732 Q92995 Q969Q1 Q9BYV2 Q9BYV6	1:1:1:1:1	CompleatCFinder	Compleat:HC4246

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western blottingFlow cytometryMORPH	3	41216884 40748658 38321535

Sequence, Structure & Domains

Sequences

Length

358

Mass

40,301

Sequence

MNFTVGFKPLLGDAHSMDNLEKQLICPICLEMFSKPVVILPCQHNLCRKCANDVFQASNPLWQSRGSTTVSSGGRFRCPSCRHEVVLDRHGVYGLQRNLLVENIIDIYKQESSRPLHSKAEQHLMCEEHEEEKINIYCLSCEVPTCSLCKVFGAHKDCEVAPLPTIYKRQKSELSDGIAMLVAGNDRVQAVITQMEEVCQTIEDNSRRQKQLLNQRFESLCAVLEERKGELLQALAREQEEKLQRVRGLIRQYGDHLEASSKLVESAIQSMEEPQMALYLQQAKELINKVGAMSKVELAGRPEPGYESMEQFTVRVEHVAEMLRTIDFQPGASGEEEEVAPDGEEGSAGPEEERPDGP

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BYV2-1; Sequence=Displayed; Name=2; IsoId=Q9BYV2-2; Sequence=VSP_016061

Alternative Sequence

171; K -> KKQDLTLLPRLECSGTNTTYCSLDLPSSSDPPILASQNTKIID (in isoform 2)

3D Structural Models

Turn

139..142; 154..157

Helix

147..151; 164..166

Beta Strand

127..129; 132..138; 143..146; 160..162

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

334..345; Acidic residues

Coiled Coil

220..258

Zinc Finger

26..82; RING-type; 121..163; B box-type

Domain (FT)

271..329; COS

Region

168..211; Mediates microtubule-binding and homooligomerization; 326..358; Disordered

Clinical Relevance

Antibody

HPA019690

Interaction Protein

ENSG00000042286ENSG00000089723ENSG00000131508

Interaction Count

Interaction Dataset

intact_biogrid