Protein detail
TRI54
Tripartite motif-containing protein 54 (Muscle-specific RING finger protein) (MuRF) (Muscle-specific RING finger protein 3) (MuRF-3) (MuRF3) (RING finger protein 30)
Entry name TRI54 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 3 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Tripartite motif-containing protein 54 (Muscle-specific RING finger protein) (MuRF) (Muscle-specific RING finger protein 3) (MuRF-3) (MuRF3) (RING finger protein 30)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
MURFMURF-3RNF30
Gene Description
Tripartite motif containing 54
Chromosome
2
Position
27282429-27307439
Supporting publications (n)
3
EVMP confidence score
0.38
Fluorescence & Localization1
Cell SpecificEsophageal apical cells
Function & Pathway6
Protein Function
Predicted intracellular proteins
Cellular Component (4)
Molecular Function (4)
Biological Process (3)
Mediation Categories
Immune mediation
Relations & Evidence147
Ligand-Receptor Signaling (5)
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network (136)
136 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| COMPLEX:P0CG47_Q15819 | TRI54 | Q9BYV2 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P62987_Q8WVN8 | TRI54 | Q9BYV2 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:O00762_P62987 | TRI54 | Q9BYV2 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P49459_P62979 | TRI54 | Q9BYV2 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P0CG48_P62253 | TRI54 | Q9BYV2 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P0CG47_Q9H832 | TRI54 | Q9BYV2 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P0CG48_Q8N2K1 | TRI54 | Q9BYV2 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P62979_Q969T4 | TRI54 | Q9BYV2 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P0CG48_Q712K3 | TRI54 | Q9BYV2 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P62979_Q9H832 | TRI54 | Q9BYV2 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 |
Protein Complex Composition (5)
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| Ub:RING_E3 | TRIM54UBB | P0CG47Q9BYV2 | 0:0 | SIGNOR | SIGNOR:SIGNOR-C519 | |
| Ub:RING_E3 | TRIM54UBC | P0CG48Q9BYV2 | 0:0 | SIGNOR | SIGNOR:SIGNOR-C519 | |
| Ub:RING_E3 | RPS27ATRIM54 | P62979Q9BYV2 | 0:0 | SIGNOR | SIGNOR:SIGNOR-C519 | |
| Ub:RING_E3 | TRIM54UBA52 | P62987Q9BYV2 | 0:0 | SIGNOR | SIGNOR:SIGNOR-C519 | |
| CKMTRIM54TRIM55TRIM63USP13 | P06732Q92995Q969Q1Q9BYV2Q9BYV6 | 1:1:1:1:1 | CompleatCFinder | Compleat:HC4246 |
Sequence, Structure & Domains14
Sequences
Length
358
Mass
40,301
Sequence
MNFTVGFKPLLGDAHSMDNLEKQLICPICLEMFSKPVVILPCQHNLCRKCANDVFQASNPLWQSRGSTTVSSGGRFRCPSCRHEVVLDRHGVYGLQRNLLVENIIDIYKQESSRPLHSKAEQHLMCEEHEEEKINIYCLSCEVPTCSLCKVFGAHKDCEVAPLPTIYKRQKSELSDGIAMLVAGNDRVQAVITQMEEVCQTIEDNSRRQKQLLNQRFESLCAVLEERKGELLQALAREQEEKLQRVRGLIRQYGDHLEASSKLVESAIQSMEEPQMALYLQQAKELINKVGAMSKVELAGRPEPGYESMEQFTVRVEHVAEMLRTIDFQPGASGEEEEVAPDGEEGSAGPEEERPDGP
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BYV2-1; Sequence=Displayed; Name=2; IsoId=Q9BYV2-2; Sequence=VSP_016061
Alternative Sequence
171; K -> KKQDLTLLPRLECSGTNTTYCSLDLPSSSDPPILASQNTKIID (in isoform 2)
3D Structural Models
Turn
139..142; 154..157
Helix
147..151; 164..166
Beta Strand
127..129; 132..138; 143..146; 160..162
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
334..345; Acidic residues
Coiled Coil
220..258
Zinc Finger
26..82; RING-type; 121..163; B box-type
Domain (FT)
271..329; COS
Region
168..211; Mediates microtubule-binding and homooligomerization; 326..358; Disordered
Clinical Relevance4
Antibody
Interaction Protein (3)
ENSG00000042286ENSG00000089723ENSG00000131508
Interaction Count
3
Interaction Dataset
intact_biogrid
Supporting Publications3
| PMID | Title | Abstract |
|---|---|---|
| 37922300 | Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women. | No abstract available |
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No abstract available |
| 40098346 | Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays. | No abstract available |