Protein detail

RHBT2

Rho-related BTB domain-containing protein 2 (Deleted in breast cancer 2 gene protein) (p83)

Entry name RHBT2	UniProt ID Q9BYZ6	EVMP confidence score 0.40
Supporting publications (n) 4	Transmembrane count	Protein classification Disease related genesHuman disease related genesPredicted intracellular proteins

Basic Information

Protein Names

Rho-related BTB domain-containing protein 2 (Deleted in breast cancer 2 gene protein) (p83)

Protein Class (3)

Disease related genesHuman disease related genesPredicted intracellular proteins

Protein Function (3)

Human disease related genes:Nervous system diseases:Epilepsy
Disease related genes
Predicted intracellular proteins

Ensembl

ENSG00000008853

Entrez Gene Symbol

RHOBTB2

Gene Synonym (2)

DBC2KIAA0717

Gene Description

Rho related BTB domain containing 2

Chromosome

Position

22987417-23020509

Supporting publications (n)

EVMP confidence score

0.40

Fluorescence & Localization

Tissue SpecificbrainCell SpecificChoroid plexus epithelial cellsSingle-Nuclei Brain Specificchoroid plexus epithelial cell

Function & Pathway

Protein Function (3)

Human disease related genes:Nervous system diseases:Epilepsy
Disease related genes
Predicted intracellular proteins

Cellular Component (2)

Molecular Function (4)

Biological Process (3)

KEGG

hsa04120 Ubiquitin mediated proteolysis

Reactome (4)

Canonical Pathways (2)

M16 Pid insulin pathway
M7955 Sig insulin receptor pathway in cardiac myocytes

Mediation Categories (2)

Fusion and delivery mediationReceptor-signaling mediation

Relations & Evidence7

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database
intracellular	intracellular	LOCATE
intracellular	intracellular	ComPPI
intracellular	intracellular	GO_Intercell
intracellular	intracellular	OmniPath

Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	APBB3 RHOBTB1 RHOBTB2	O94844 O95704 Q9BYZ6	0:0:0	hu.MAP2
	APBB3 RHOBTB2	O95704 Q9BYZ6	0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Western blottingFlow cytometry	1	38321535

Sequence, Structure & Domains

Sequences

Length

727

Mass

82,626

Sequence

MDSDMDYERPNVETIKCVVVGDNAVGKTRLICARACNATLTQYQLLATHVPTVWAIDQYRVCQEVLERSRDVVDDVSVSLRLWDTFGDHHKDRRFAYGRSDVVVLCFSIANPNSLHHVKTMWYPEIKHFCPRAPVILVGCQLDLRYADLEAVNRARRPLARPIKPNEILPPEKGREVAKELGIPYYETSVVAQFGIKDVFDNAIRAALISRRHLQFWKSHLRNVQRPLLQAPFLPPKPPPPIIVVPDPPSSSEECPAHLLEDPLCADVILVLQERVRIFAHKIYLSTSSSKFYDLFLMDLSEGELGGPSEPGGTHPEDHQGHSDQHHHHHHHHHGRDFLLRAASFDVCESVDEAGGSGPAGLRASTSDGILRGNGTGYLPGRGRVLSSWSRAFVSIQEEMAEDPLTYKSRLMVVVKMDSSIQPGPFRAVLKYLYTGELDENERDLMHIAHIAELLEVFDLRMMVANILNNEAFMNQEITKAFHVRRTNRVKECLAKGTFSDVTFILDDGTISAHKPLLISSCDWMAAMFGGPFVESSTREVVFPYTSKSCMRAVLEYLYTGMFTSSPDLDDMKLIILANRLCLPHLVALTEQYTVTGLMEATQMMVDIDGDVLVFLELAQFHCAYQLADWCLHHICTNYNNVCRKFPRDMKAMSPENQEYFEKHRWPPVWYLKEEDHYQRARKEREKEDYLHLKRQPKRRWLFWNSPSSPSSSAASSSSPSSSSAVV

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9BYZ6-1; Sequence=Displayed; Name=2; IsoId=Q9BYZ6-2; Sequence=VSP_054098; Name=3; IsoId=Q9BYZ6-3; Sequence=VSP_054099

Alternative Sequence

1; M -> MQAWRKGPDGPQKTSSDSMSRLM (in isoform 2); 1; M -> MKARSRLM (in isoform 3)

Domain & Motif Annotations

Compositional Bias

315..324; Basic and acidic residues; 706..727; Low complexity

Domain (FT)

266..442; BTB 1; 500..567; BTB 2

Region

1..210; Rho-like; 304..333; Disordered; 703..727; Disordered

Protein Families (2)

Small GTPase superfamily
Rho family

Sequence Similarities

Belongs to the small GTPase superfamily. Rho family.

Clinical Relevance

Disease Involvement (2)

Disease variantEpilepsy

Related Diseases

Epilepsy

Antibody

HPA060938

Supporting Publications4

PMID	Title	Related sentences
22106071	Proteomic analysis of urine exosomes by multidimensional protein identification technology (MudPIT).	No related sentences available
33729255	A new urinary exosome enrichment method by a combination of ultrafiltration and TiO2 nanoparticles.	No related sentences available
37686366	Identification of a Non-Invasive Urinary Exosomal Biomarker for Diabetic Nephropathy Using Data-Independent Acquisition Proteomics.	No related sentences available
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No related sentences available