Protein detail
ADA33
Disintegrin and metalloproteinase domain-containing protein 33 (ADAM 33) (EC 3.4.24.-)
Entry name ADA33 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification Disease related genesHuman disease related genesPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Disintegrin and metalloproteinase domain-containing protein 33 (ADAM 33) (EC 3.4.24.-)
Protein Class (3)
Disease related genesHuman disease related genesPredicted membrane proteins
Protein Function (2)
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- Disease related genes
Transmembrane
702..722; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
C20orf153dJ964F7.1DKFZp434K0521
Gene Description
ADAM metallopeptidase domain 33
Chromosome
20
Position
3667965-3682246
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization2
Tissue SpecificliverCell SpecificCholangiocytes
Function & Pathway7
Protein Function (2)
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- Disease related genes
Cellular Component
Molecular Function (3)
Biological Process (3)
Reactome (6)
- R-hsa-418990 adherens junctions interactions
- R-hsa-1500931 cell cell communication
- R-hsa-446728 cell junction organization
- R-hsa-9762292 regulation of cdh11 function
- R-hsa-9764260 regulation of expression and function of type ii classical cadherins
- R-hsa-9759476 regulation of homotypic cell cell adhesion
Canonical Pathways (3)
- M203 Pid alk2 pathway
- M185 Pid alk1 pathway
- M181 Pid bmp pathway
Mediation Categories
Receptor-signaling mediation
Relations & Evidence24
Ligand-Receptor Signaling (23)
23 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane_predicted | transmembrane | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
| transmembrane | transmembrane | LOCATE | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| receptor | receptor | scConnect | No | Yes | No | Yes | No |
Sequence, Structure & Domains14
Sequences
Length
813
Mass
87,739
Sequence
MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACHSHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLDPENSHEPSSHPEKPLPAVSPDPQADQVQMPRSCLW
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9BZ11-1; Sequence=Displayed; Name=2; IsoId=Q9BZ11-2; Sequence=VSP_005495; Name=3; IsoId=Q9BZ11-3; Sequence=VSP_015421, VSP_005495
Alternative Sequence
1..478; Missing (in isoform 3); 636..661; Missing (in isoform 2 and isoform 3)
3D Structural Models
Turn
226..228; 322..324; 399..402
Helix
220..225; 230..248; 249..251; 275..292; 307..309; 336..350; 366..368; 387..398; 403..406
Beta Strand
210..218; 253..262; 264..266; 296..303; 326..330; 333..335
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
780..791; Basic and acidic residues
Motif
131..138; Cysteine switch
Domain (CC)
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Domain (FT)
210..409; Peptidase M12B; 417..503; Disintegrin; 649..681; EGF-like
Region
184..205; Disordered; 746..813; Disordered
Clinical Relevance3
Disease Involvement
Asthma
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 32795414 | Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers. | Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers. |