Protein detail
PC11X
Protocadherin-11 X-linked (Protocadherin-11) (Protocadherin on the X chromosome) (PCDH-X) (Protocadherin-S)
Entry name PC11X | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification Predicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Protocadherin-11 X-linked (Protocadherin-11) (Protocadherin on the X chromosome) (PCDH-X) (Protocadherin-S)
Protein Class
Predicted membrane proteins
Transmembrane
813..833; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
PCDH-XPCDH11PCDHXPPP1R119
Gene Description
Protocadherin 11 X-linked
Chromosome
X
Position
91779261-92623230
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificbrainCell SpecificBergmann gliaBlood Cell Specificnaive B-cellBlood Lineage SpecificB-cells
Function & Pathway
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Adhesion and uptake mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
21 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| non_clustered_protocadherin | cell_adhesion | HGNC | Yes | Yes | No | Yes | No |
| adhesion | adhesion | HGNC | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | Zhong2015 | Yes | Yes | No | Yes | No |
| icam | cell_adhesion | Zhong2015 | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | HGNC | Yes | Yes | No | Yes | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains
Sequences
Length
1,347
Mass
147,558
Sequence
MDLLSGTYIFAVLLACVVFHSGAQEKNYTIREEMPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSTEAPVTPNTEIADVSSPTSDYVKILVAAVAGTITVVVVIFITAVVRCRQAPHLKAAQKNKQNSEWATPNPENRQMIMMKKKKKKKKHSPKNLLLNFVTIEETKADDVDSDGNRVTLDLPIDLEEQTMGKYNWVTTPTTFKPDSPDLARHYKSASPQPAFQIQPETPLNSKHHIIQELPLDNTFVACDSISKCSSSSSDPYSVSDCGYPVTTFEVPVSVHTRPPMKEVVRSCTPMKESTTMEIWIHPQPQRKSEGKVAGKSQRRVTFHLPEGSQESSSDGGLGDHDAGSLTSTSHGLPLGYPQEEYFDRATPSNRTEGDGNSDPESTFIPGLKKAAEITVQPTVEEASDNCTQECLIYGHSDACWMPASLDHSSSSQAQASALCHSPPLSQASTQHHSPRVTQTIALCHSPPVTQTIALCHSPPPIQVSALHHSPPLVQATALHHSPPSAQASALCYSPPLAQAAAISHSSPLPQVIALHRSQAQSSVSLQQGWVQGADGLCSVDQGVQGSATSQFYTMSERLHPSDDSIKVIPLTTFTPRQQARPSRGDSPIMEEHPL
Alternative Products
Event=Alternative splicing; Named isoforms=8; Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q9BZA7-1; Sequence=Displayed; Name=2; IsoId=Q9BZA7-2; Sequence=VSP_017980, VSP_017983; Name=3; IsoId=Q9BZA7-3; Sequence=VSP_017984; Name=4; IsoId=Q9BZA7-4; Sequence=VSP_017984, VSP_017987; Name=5; IsoId=Q9BZA7-5; Sequence=VSP_017979; Name=6; IsoId=Q9BZA7-6; Sequence=VSP_017985, VSP_017986; Name=7; Synonyms=Protocadherin-Xa; IsoId=Q9BZA7-7; Sequence=VSP_017981, VSP_017982; Name=8; IsoId=Q9BZA7-8; Sequence=VSP_017987
Alternative Sequence
1012..1048; Missing (in isoform 5); 1012..1025; PMKEVVRSCTPMKE -> TDSRTSTIEICSEI (in isoform 2); 1012..1021; PMKEVVRSCT -> VGIQVSNTTF (in isoform 7); 1022..1347; Missing (in isoform 7); 1026..1347; Missing (in isoform 2); 1039..1048; Missing (in isoform 3 and isoform 4); 1049..1065; SQRRVTFHLPEGSQESS -> TVLTSSSPSAMTLSYLD (in isoform 6); 1066..1347; Missing (in isoform 6); 1116..1123; Missing (in isoform 8 and isoform 4)
3D Structural Models
Domain & Motif Annotations
Domain (FT)
26..139; Cadherin 1; 140..249; Cadherin 2; 250..355; Cadherin 3; 362..466; Cadherin 4; 467..570; Cadherin 5; 571..673; Cadherin 6; 677..795; Cadherin 7
Region
1057..1091; Disordered; 1097..1116; Disordered; 1326..1347; Disordered