Protein detail

PPAT

Testicular acid phosphatase (EC 3.1.3.2) (Acid phosphatase 4)

Entry name PPAT	UniProt ID Q9BZG2	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 1	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Testicular acid phosphatase (EC 3.1.3.2) (Acid phosphatase 4)

Protein Function (5)

Human disease related genes:Digestive system diseases:Mouth and dental diseases
Potential drug targets
Enzymes
ENZYME proteins:Hydrolases
Disease related genes

Transmembrane

394..414; Helical

Transmembrane Count

Ensembl

ENSG00000142513

Entrez Gene Symbol

ACP4

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization4

Tissue SpecificbrainCell SpecificCorticotrophsSingle-Nuclei Brain Specificoligodendrocyte

Function & Pathway5

Protein Function (5)

Human disease related genes:Digestive system diseases:Mouth and dental diseases
Potential drug targets
Enzymes
ENZYME proteins:Hydrolases
Disease related genes

Cellular Component (3)

Molecular Function (3)

Biological Process (3)

Mediation Categories (2)

Metabolism mediationReceptor-signaling mediation

Relations & Evidence25

Ligand-Receptor Signaling (23)

23 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane_phobius	transmembrane_predicted	Almen2009	No	No	No	Yes	No
transmembrane_sosui	transmembrane_predicted	Almen2009	No	No	No	Yes	No
transmembrane_tmhmm	transmembrane_predicted	Almen2009	No	No	No	Yes	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
HT_DM_Cluster243	ACP2 ACP3 ACP4 CYP3A4 CYP3A43 CYP3A5 CYP3A7 TBXAS1	P08684 P11117 P15309 P20815 P24462 P24557 Q9BZG2 Q9HB55	1:1:1:1:1:1:1:1	Compleat	Compleat:HC3101	22036573

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration	Western blotting	2	41227296 38731868

Sequence, Structure & Domains7

Sequences

Length

426

Mass

46,090

Sequence

MAGLGFWGHPAGPLLLLLLLVLPPRALPEGPLVFVALVFRHGDRAPLASYPMDPHKEVASTLWPRGLGQLTTEGVRQQLELGRFLRSRYEAFLSPEYRREEVYIRSTDFDRTLESAQANLAGLFPEAAPGSPEARWRPIPVHTVPVAEDKLLRFPMRSCPRYHELLREATEAAEYQEALEGWTGFLSRLENFTGLSLVGEPLRRAWKVLDTLMCQQAHGLPLPAWASPDVLRTLAQISALDIGAHVGPPRAAEKAQLTGGILLNAILANFSRVQRLGLPLKMVMYSAHDSTLLALQGALGLYDGHTPPYAACLGFEFRKHLGNPAKDGGNVTVSLFYRNDSAHLPLPLSLPGCPAPCPLGRFYQLTAPARPPAHGVSCHGPYEAAIPPAPVVPLLAGAVAVLVALSLGLGLLAWRPGCLRALGGPV

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9BZG2-1; Sequence=Displayed; Name=2; Synonyms=Variant 3; IsoId=Q9BZG2-2; Sequence=VSP_021494; Name=3; Synonyms=Truncated variant 1, Truncated variant 2; IsoId=Q9BZG2-3; Sequence=VSP_021493, VSP_021495

Alternative Sequence

39..92; FRHGDRAPLASYPMDPHKEVASTLWPRGLGQLTTEGVRQQLELGRFLRSRYEAF -> RRPHPGLPLAPPGLALTSPVPRYSAMATGPRWPPTPWTHTRRWPPPCGHEAWAS (in isoform 3); 91..183; Missing (in isoform 2); 93..426; Missing (in isoform 3)

Domain & Motif Annotations

Protein Families

Histidine acid phosphatase family

Sequence Similarities

Belongs to the histidine acid phosphatase family.

Supporting Publications1

PMID	Title	Abstract
24196483	Subfractionation, characterization, and in-depth proteomic analysis of glomerular membrane vesicles in human urine.	No abstract available