Protein detail
ULBP2
UL16-binding protein 2 (ALCAN-alpha) (NKG2D ligand 2) (N2DL-2) (NKG2DL2) (Retinoic acid early transcript 1H)
Entry name ULBP2 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Predicted membrane proteinsPredicted secreted proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
UL16-binding protein 2 (ALCAN-alpha) (NKG2D ligand 2) (N2DL-2) (NKG2DL2) (Retinoic acid early transcript 1H)
Protein Class (2)
Predicted membrane proteinsPredicted secreted proteins
Protein Function
Predicted secreted proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
RAET1H
Gene Description
UL16 binding protein 2
Chromosome
6
Position
149942014-149949235
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization1
Function & Pathway6
Protein Function
Predicted secreted proteins
Cellular Component (7)
Molecular Function (3)
Reactome (2)
Mediation Categories (3)
Fusion and delivery mediationImmune mediationMetabolism mediation
Relations & Evidence57
Ligand-Receptor Signaling (55)
55 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | GO_Intercell | No | Yes | Yes | Yes | Yes |
| receptor | receptor | OmniPath | No | Yes | Yes | Yes | Yes |
| ecm | ecm | MatrixDB | Yes | No | Yes | Yes | Yes |
| ecm | ecm | OmniPath | Yes | No | Yes | Yes | Yes |
| extracellular | extracellular | HPMR | No | No | Yes | Yes | Yes |
| extracellular | extracellular | DGIdb | No | No | Yes | Yes | Yes |
| extracellular | extracellular | OmniPath | No | No | Yes | Yes | Yes |
| intracellular | intracellular | ComPPI | No | No | Yes | Yes | Yes |
| intracellular | intracellular | GO_Intercell | No | No | Yes | Yes | Yes |
| intracellular | intracellular | UniProt_location | No | No | Yes | Yes | Yes |
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Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| ULBP2 | Q9BZM5 | NKG2D | P26718 | Yes | Yes | No | HPMRCellChatDBFantom5_LRdbCellTalkDBHPMR_LRdbiTALKtalklrRamilowski2015SIGNORconnectomeDB2020IntActWangLRdbHPMR_talklr | LRdb:10894171HPMR:10894171IntAct:28559451CellTalkDB:10894171CellChatDB:24223577IntAct:19424970connectomeDB2020:10894171connectomeDB2020:26041808SIGNOR:10894171 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Density Gradient CentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 34817906 |
Sequence, Structure & Domains9
Sequences
Length
246
Mass
27,368
Sequence
MAAAAATKILLCLPLLLLLSGWSRAGRADPHSLCYDITVIPKFRPGPRWCAVQGQVDEKTFLHYDCGNKTVTPVSPLGKKLNVTTAWKAQNPVLREVVDILTEQLRDIQLENYTPKEPLTLQARMSCEQKAEGHSSGSWQFSFDGQIFLLFDSEKRMWTTVHPGARKMKEKWENDKVVAMSFHYFSMGDCIGWLEDFLMGMDSTLEPSAGAPLAMSSGTTQLRATATTLILCCLLIILPCFILPGI
3D Structural Models
Turn
226..229
Helix
230..235; 238..241
3D Structure
Electron microscopy (2)
Domain & Motif Annotations
Region
29..117; MHC class I alpha-1 like; 118..210; MHC class I alpha-2 like
Protein Families
MHC class I family
Sequence Similarities
Belongs to the MHC class I family.
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 30550287 | Label-Free Proteomic Analysis of Exosomes Secreted from THP-1-Derived Macrophages Treated with IFN-α Identifies Antiviral Proteins Enriched in Exosomes. | No abstract available |