Protein detail
CD244
Natural killer cell receptor 2B4 (NK cell activation-inducing ligand) (NAIL) (NK cell type I receptor protein 2B4) (NKR2B4) (h2B4) (SLAM family member 4) (SLAMF4) (Signaling lymphocytic activation molecule 4) (CD antigen CD244)
Protein symbol CD244 | UniProt ID | EVMP score 0.25 |
Frequency 2 | Transmembrane count 1 | Protein classification |
Basic Information
Protein Names
Natural killer cell receptor 2B4 (NK cell activation-inducing ligand) (NAIL) (NK cell type I receptor protein 2B4) (NKR2B4) (h2B4) (SLAM family member 4) (SLAMF4) (Signaling lymphocytic activation molecule 4) (CD antigen CD244)
Protein Function
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- CD markers
Transmembrane
230..250; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Frequency
2
EVMP Score
0.25
Fluorescence & Localization
Cell SpecificBreast lactating cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificbasophilBlood Lineage Specificdendritic cells
Function & Pathway
Protein Function
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- CD markers
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Fusion and delivery mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
44 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_surface_ligand | cell_surface_ligand | connectomeDB2020 | Yes | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | Baccin2019 | Yes | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | OmniPath | Yes | No | No | Yes | No |
| ig_like | cell_adhesion | HGNC | Yes | Yes | No | Yes | No |
| adhesion | adhesion | HGNC | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | HGNC | Yes | Yes | No | Yes | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Density Gradient CentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 34817906 |
Sequence, Structure & Domains
Sequences
Length
370
Mass
41,616
Sequence
MLGQVVTLILLLLLKVYQGKGCQGSADHVVSISGVPLQLQPNSIQTKVDSIAWKKLLPSQNGFHHILKWENGSLPSNTSNDRFSFIVKNLSLLIKAAQQQDSGLYCLEVTSISGKVQTATFQVFVFESLLPDKVEKPRLQGQGKILDRGRCQVALSCLVSRDGNVSYAWYRGSKLIQTAGNLTYLDEEVDINGTHTYTCNVSNPVSWESHTLNLTQDCQNAHQEFRFWPFLVIIVILSALFLGTLACFCVWRRKRKEKQSETSPKEFLTIYEDVKDLKTRRNHEQEQTFPGGGSTIYSMIQSQSSAPTSQEPAYTLYSLIQPSRKSGSRKRNHSPSFNSTIYEVIGKSQPKAQNPARLSRKELENFDVYS
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=H2B4-B; IsoId=Q9BZW8-1; Sequence=Displayed; Name=2; Synonyms=H2B4-A; IsoId=Q9BZW8-2; Sequence=VSP_010397; Name=3; Synonyms=H2B4; IsoId=Q9BZW8-3; Sequence=VSP_010397, VSP_010399, VSP_010400; Name=4; Synonyms=H2B4b; IsoId=Q9BZW8-4; Sequence=VSP_010398
Alternative Sequence
127..131; Missing (in isoform 2 and isoform 3); 128..224; Missing (in isoform 4); 326..334; SGSRKRNHS -> GDRFYSFSG (in isoform 3); 335..370; Missing (in isoform 3)
3D Structural Models
Domain & Motif Annotations
Motif
269..274; ITSM 1; 295..300; ITSM 2; 315..320; ITSM 3; 340..345; ITSM 4
Domain (CC)
The ITSMs (immunoreceptor tyrosine-based switch motifs) with the consensus sequence T-X-Y-X-X-[VI] present in SLAM family receptors have overlapping specificity for activating and inhibitory SH2 domain-containing binding partners. Especially they mediate the interaction with the SH2 domain of SH2D1A and SH2D1B. A 'three-pronged' mechanism is proposed involving threonine (position -2), phosphorylated tyrosine (position 0) and valine/isoleucine (position +3).
Domain (FT)
22..127; Ig-like 1; 131..215; Ig-like 2
Region
324..370; Disordered
Clinical Relevance
Drugs
Interaction Protein
ENSG00000183918
Interaction Count
1
Interaction Dataset
intact_biogrid