Protein detail
CD244
Natural killer cell receptor 2B4 (NK cell activation-inducing ligand) (NAIL) (NK cell type I receptor protein 2B4) (NKR2B4) (h2B4) (SLAM family member 4) (SLAMF4) (Signaling lymphocytic activation molecule 4) (CD antigen CD244)
Entry name CD244 | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 2 | Transmembrane count 1 | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information8
Protein Names
Natural killer cell receptor 2B4 (NK cell activation-inducing ligand) (NAIL) (NK cell type I receptor protein 2B4) (NKR2B4) (h2B4) (SLAM family member 4) (SLAMF4) (Signaling lymphocytic activation molecule 4) (CD antigen CD244)
Protein Function (2)
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- CD markers
Transmembrane
230..250; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Supporting publications (n)
2
EVMP confidence score
0.25
Fluorescence & Localization4
Cell SpecificBreast lactating cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificbasophilBlood Lineage Specificdendritic cells
Function & Pathway7
Protein Function (2)
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- CD markers
Cellular Component (2)
Molecular Function (3)
Biological Process (3)
Mediation Categories (2)
Fusion and delivery mediationImmune mediation
Relations & Evidence45
Ligand-Receptor Signaling (44)
44 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
| transmembrane_phobius | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
| transmembrane_sosui | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
| transmembrane_tmhmm | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Density Gradient CentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 34817906 |
Sequence, Structure & Domains9
Sequences
Length
370
Mass
41,616
Sequence
MLGQVVTLILLLLLKVYQGKGCQGSADHVVSISGVPLQLQPNSIQTKVDSIAWKKLLPSQNGFHHILKWENGSLPSNTSNDRFSFIVKNLSLLIKAAQQQDSGLYCLEVTSISGKVQTATFQVFVFESLLPDKVEKPRLQGQGKILDRGRCQVALSCLVSRDGNVSYAWYRGSKLIQTAGNLTYLDEEVDINGTHTYTCNVSNPVSWESHTLNLTQDCQNAHQEFRFWPFLVIIVILSALFLGTLACFCVWRRKRKEKQSETSPKEFLTIYEDVKDLKTRRNHEQEQTFPGGGSTIYSMIQSQSSAPTSQEPAYTLYSLIQPSRKSGSRKRNHSPSFNSTIYEVIGKSQPKAQNPARLSRKELENFDVYS
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=H2B4-B; IsoId=Q9BZW8-1; Sequence=Displayed; Name=2; Synonyms=H2B4-A; IsoId=Q9BZW8-2; Sequence=VSP_010397; Name=3; Synonyms=H2B4; IsoId=Q9BZW8-3; Sequence=VSP_010397, VSP_010399, VSP_010400; Name=4; Synonyms=H2B4b; IsoId=Q9BZW8-4; Sequence=VSP_010398
Alternative Sequence
127..131; Missing (in isoform 2 and isoform 3); 128..224; Missing (in isoform 4); 326..334; SGSRKRNHS -> GDRFYSFSG (in isoform 3); 335..370; Missing (in isoform 3)
Domain & Motif Annotations
Motif
269..274; ITSM 1; 295..300; ITSM 2; 315..320; ITSM 3; 340..345; ITSM 4
Domain (CC)
The ITSMs (immunoreceptor tyrosine-based switch motifs) with the consensus sequence T-X-Y-X-X-[VI] present in SLAM family receptors have overlapping specificity for activating and inhibitory SH2 domain-containing binding partners. Especially they mediate the interaction with the SH2 domain of SH2D1A and SH2D1B. A 'three-pronged' mechanism is proposed involving threonine (position -2), phosphorylated tyrosine (position 0) and valine/isoleucine (position +3).
Domain (FT)
22..127; Ig-like 1; 131..215; Ig-like 2
Region
324..370; Disordered
Clinical Relevance4
Drugs
Interaction Protein
ENSG00000183918
Interaction Count
1
Interaction Dataset
intact_biogrid
Supporting Publications2
| PMID | Title | Abstract |
|---|---|---|
| 30865381 | Surfaceome of Exosomes Secreted from the Colorectal Cancer Cell Line SW480: Peripheral and Integral Membrane Proteins Analyzed by Proteolysis and TX114. | No abstract available |
| 32384937 | Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles. | No abstract available |