Protein detail

TB182

182 kDa tankyrase-1-binding protein

Protein symbol TB182	UniProt ID Q9C0C2	EVMP score 0.38
Frequency 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

182 kDa tankyrase-1-binding protein

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000149115

Entrez Gene Symbol

TNKS1BP1

Gene Synonym

FLJ45975KIAA1741TAB182

Gene Description

Tankyrase 1 binding protein 1

Chromosome

Position

57299638-57324952

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue SpecifickidneyCell SpecificBasal keratinocytesSingle-Nuclei Brain SpecificleukocyteBlood Cell Specificintermediate monocyteBlood Lineage Specificmonocytes

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

Reactome

Mediation Categories

Fusion and delivery mediation

Relations & Evidence

Enzyme-Mediated Modification

17 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
TNKS1BP1	GSK3B	P49841	S	691	phosphorylation	KEA	KEA:17570479
TNKS1BP1	MAPK9	P45984	S	1,385	phosphorylation	KEA	KEA:17570479
TNKS1BP1	MAPK9	P45984	S	672	phosphorylation	KEA	KEA:17570479
TNKS1BP1	MAPK9	P45984	S	691	phosphorylation	KEA	KEA:17570479
TNKS1BP1	PRKDC	P78527	S	1,383	phosphorylation	KEA	KEA:17570479
TNKS1BP1	RPS6KA3	P51812	S	1,666	phosphorylation	KEA	KEA:17570479
TNKS1BP1	SGK1	O00141	S	1,666	phosphorylation	KEA	KEA:17570479

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Ligand-Receptor Signaling

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
MK01	P28482	TB182	Q9C0C2	Yes	No	No	iPTMnetSIGNORProtMapperKEASIGNOR_ProtMapperNetworKIN_KEA	KEA:17570479 ProtMapper:22028470 SIGNOR:22028470

Protein Complex Composition

14 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
CCR4-NOT complex	CNOT1 CNOT10 CNOT11 CNOT2 CNOT3 CNOT4 CNOT6 CNOT6L CNOT7 CNOT8 CNOT9 TNKS1BP1	A5YKK6 O75175 O95628 Q92600 Q96LI5 Q9C0C2 Q9H9A5 Q9NZN8 Q9UFF9 Q9UIV1 Q9UKZ1 Q9ULM6	0:0:0:0:0:0:0:0:0:0:0:0	SIGNOR	SIGNOR:SIGNOR-C439
CCR4-NOT mRNA deadenylase complexCNOT6-CNOT7 variant	CNOT1 CNOT10 CNOT11 CNOT2 CNOT3 CNOT4 CNOT6 CNOT7 CNOT9 TNKS1BP1	A5YKK6 O75175 O95628 Q92600 Q9C0C2 Q9H9A5 Q9NZN8 Q9UIV1 Q9UKZ1 Q9ULM6	1:1:1:1:1:1:1:1:1:1	ComplexPortal	intact:EBI-12517317PDB:5fu6PDB:7ax1PDB:4GMJPDB:4c0d	31320642 24121232 19558367 33138308 14755292
CCR4-NOT mRNA deadenylase complexCNOT6-CNOT8 variant	CNOT1 CNOT10 CNOT11 CNOT2 CNOT3 CNOT4 CNOT6 CNOT8 CNOT9 TNKS1BP1	A5YKK6 O75175 O95628 Q92600 Q9C0C2 Q9H9A5 Q9NZN8 Q9UFF9 Q9UKZ1 Q9ULM6	1:1:1:1:1:1:1:1:1:1	ComplexPortal	PDB:5fu6PDB:7ax1intact:EBI-9026904PDB:4GMJPDB:4c0d	31320642 24121232 19558367 33138308 14755292
CCR4-NOT mRNA deadenylase complexCNOT6L-CNOT7 variant	CNOT1 CNOT10 CNOT11 CNOT2 CNOT3 CNOT4 CNOT6L CNOT7 CNOT9 TNKS1BP1	A5YKK6 O75175 O95628 Q92600 Q96LI5 Q9C0C2 Q9H9A5 Q9NZN8 Q9UIV1 Q9UKZ1	1:1:1:1:1:1:1:1:1:1	ComplexPortal	intact:EBI-9018916PDB:5fu6PDB:7ax1PDB:4GMJPDB:4c0d	31320642 24121232 19558367 33138308 14755292
CCR4-NOT mRNA deadenylase complexCNOT6L-CNOT8 variant	CNOT1 CNOT10 CNOT11 CNOT2 CNOT3 CNOT4 CNOT6L CNOT8 CNOT9 TNKS1BP1	A5YKK6 O75175 O95628 Q92600 Q96LI5 Q9C0C2 Q9H9A5 Q9NZN8 Q9UFF9 Q9UKZ1	1:1:1:1:1:1:1:1:1:1	ComplexPortal	intact:EBI-9019112PDB:5fu6PDB:7ax1PDB:4GMJPDB:4c0d	31320642 24121232 19558367 33138308 14755292
CCR4-NOT-CNOT7-CNOT6 complex	CNOT1 CNOT10 CNOT11 CNOT2 CNOT3 CNOT6 CNOT7 CNOT9 TNKS1BP1	A5YKK6 O75175 Q92600 Q9C0C2 Q9H9A5 Q9NZN8 Q9UIV1 Q9UKZ1 Q9ULM6	1:1:1:1:1:1:1:1:1	CompleatCORUM	Compleat:HC1106CORUM:7192	19558367
CCR4-NOT-CNOT7-CNOT6L complex	CNOT1 CNOT10 CNOT11 CNOT2 CNOT3 CNOT6L CNOT7 CNOT9 TNKS1BP1	A5YKK6 O75175 Q92600 Q96LI5 Q9C0C2 Q9H9A5 Q9NZN8 Q9UIV1 Q9UKZ1	1:1:1:1:1:1:1:1:1	CompleatCORUM	CORUM:7214Compleat:HC1725	19558367
CCR4-NOT-CNOT8-CNOT6 complex	CNOT1 CNOT10 CNOT11 CNOT2 CNOT3 CNOT6 CNOT8 CNOT9 TNKS1BP1	A5YKK6 O75175 Q92600 Q9C0C2 Q9H9A5 Q9NZN8 Q9UFF9 Q9UKZ1 Q9ULM6	1:1:1:1:1:1:1:1:1	CompleatCORUM	CORUM:7215Compleat:HC2526	19558367
CCR4-NOT-CNOT8-CNOT6L complex	CNOT1 CNOT10 CNOT11 CNOT2 CNOT3 CNOT6L CNOT8 CNOT9 TNKS1BP1	A5YKK6 O75175 Q92600 Q96LI5 Q9C0C2 Q9H9A5 Q9NZN8 Q9UFF9 Q9UKZ1	1:1:1:1:1:1:1:1:1	CompleatCORUM	CORUM:7216Compleat:HC1713	19558367
	BTG3 CNOT1 CNOT10 CNOT11 CNOT2 CNOT3 CNOT6 CNOT6L CNOT7 CNOT8 CNOT9 GARRE1 GPBP1L1 MMP7 NANOS2 OBI1 RIBC1 SMG5 TEX13A TNKS1BP1 TOB1 TOB2	A5YKK6 O15063 O75175 P09237 P50616 P60321 Q14106 Q14201 Q5W0B1 Q8N443 Q92600 Q96LI5 Q9BXU3 Q9C0C2 Q9H9A5 Q9HC44 Q9NZN8 Q9UFF9 Q9UIV1 Q9UKZ1 Q9ULM6 Q9UPR3	0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0	hu.MAP2

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Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western blotting	1	30646616

Sequence, Structure & Domains

Sequences

Length

1,729

Mass

181,796

Sequence

MKVSTLRESSAMASPLPREMEEELVPTGSEPGDTRAKPPVKPKPRALPAKPALPAKPSLLVPVGPRPPRGPLAELPSARKMNMLAGPQPYGGSKRPLPFAPRPAVEASTGGEATQETGKEEAGKEEPPPLTPPARCAAPGGVRKAPAPFRPASERFAATTVEEILAKMEQPRKEVLASPDRLWGSRLTFNHDGSSRYGPRTYGTTTAPRDEDGSTLFRGWSQEGPVKSPAECREEHSKTPEERSLPSDLAFNGDLAKAASSELPADISKPWIPSSPAPSSENGGPASPGLPAEASGSGPGSPHLHPPDKSSPCHSQLLEAQTPEASQASPCPAVTPSAPSAALPDEGSRHTPSPGLPAEGAPEAPRPSSPPPEVLEPHSLDQPPATSPRPLIEVGELLDLTRTFPSGGEEEAKGDAHLRPTSLVQRRFSEGVLQSPSQDQEKLGGSLAALPQGQGSQLALDRPFGAESNWSLSQSFEWTFPTRPSGLGVWRLDSPPPSPITEASEAAEAAEAGNLAVSSREEGVSQQGQGAGSAPSGSGSSWVQGDDPSMSLTQKGDGESQPQFPAVPLEPLPTTEGTPGLPLQQAEERYESQEPLAGQESPLPLATREAALPILEPVLGQEQPAAPDQPCVLFADAPEPGQALPVEEEAVTLARAETTQARTEAQDLCRASPEPPGPESSSRWLDDLLASPPPSGGGARRGAGAELKDTQSPSTCSEGLLGWSQKDLQSEFGITGDPQPSSFSPSSWCQGASQDYGLGGASPRGDPGLGERDWTSKYGQGAGEGSTREWASRCGIGQEEMEASSSQDQSKVSAPGVLTAQDRVVGKPAQLGTQRSQEADVQDWEFRKRDSQGTYSSRDAELQDQEFGKRDSLGTYSSRDVSLGDWEFGKRDSLGAYASQDANEQGQDLGKRDHHGRYSSQDADEQDWEFQKRDVSLGTYGSRAAEPQEQEFGKSAWIRDYSSGGSSRTLDAQDRSFGTRPLSSGFSPEEAQQQDEEFEKKIPSVEDSLGEGSRDAGRPGERGSGGLFSPSTAHVPDGALGQRDQSSWQNSDASQEVGGHQERQQAGAQGPGSADLEDGEMGKRGWVGEFSLSVGPQREAAFSPGQQDWSRDFCIEASERSYQFGIIGNDRVSGAGFSPSSKMEGGHFVPPGKTTAGSVDWTDQLGLRNLEVSSCVGSGGSSEARESAVGQMGWSGGLSLRDMNLTGCLESGGSEEPGGIGVGEKDWTSDVNVKSKDLAEVGEGGGHSQARESGVGQTDWSGVEAGEFLKSRERGVGQADWTPDLGLRNMAPGAVCSPGESKELGVGQMDWGNNLGLRDLEVTCDPDSGGSQGLRGCGVGQMDWTQDLAPQNVELFGAPSEAREHGVGGVSQCPEPGLRHNGSLSPGLEARDPLEARELGVGETSGPETQGEDYSSSSLEPHPADPGMETGEALSFGASPGRCPARPPPSGSQGLLEEMLAASSSKAVARRESAASGLGGLLEEEGAGAGAAQEEVLEPGRDSPPSWRPQPDGEASQTEDVDGTWGSSAARWSDQGPAQTSRRPSQGPPARSPSQDFSFIEDTEILDSAMYRSRANLGRKRGHRAPVIRPGGTLGLSEAADSDAHLFQDSTEPRASRVPSSDEEVVEEPQSRRTRMSLGTKGLKVNLFPGLSPSALKAKLRPRNRSAEEGELAESKSSQKESAVQRSKSCKVPGLGKPLTLPPKPEKSSGSEGSSPNWLQALKLKKKKV

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9C0C2-1; Sequence=Displayed; Name=2; IsoId=Q9C0C2-2; Sequence=VSP_026000, VSP_026001, VSP_026002

Alternative Sequence

1..549; Missing (in isoform 2); 1275..1327; GVGQADWTPDLGLRNMAPGAVCSPGESKELGVGQMDWGNNLGLRDLEVTCDPD -> LGRHIYALCITLRTPPTPSLPWISSLVVEGFVPSSPPSLSLSASSSSLPWVFF (in isoform 2); 1328..1729; Missing (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Compositional Bias

1..12; Polar residues; 46..63; Low complexity; 117..127; Basic and acidic residues; 230..245; Basic and acidic residues; 352..363; Low complexity; 364..374; Pro residues; 500..512; Low complexity; 524..541; Low complexity; 572..583; Low complexity; 738..753; Polar residues; 803..812; Polar residues; 858..872; Basic and acidic residues; 1012..1021; Basic and acidic residues; 1043..1054; Polar residues; 1389..1400; Basic and acidic residues; 1406..1419; Polar residues; 1577..1586; Basic residues; 1602..1615; Basic and acidic residues; 1665..1679; Basic and acidic residues

Motif

1629..1635; Nuclear localization signal; 1723..1729; Nuclear localization signal

Region

1..151; Disordered; 184..450; Disordered; 210..1572; Acidic; 484..603; Disordered; 657..880; Disordered; 897..1083; Disordered; 1240..1302; Disordered; 1362..1561; Disordered; 1450..1542; Tankyrase-binding; 1575..1729; Disordered

Clinical Relevance

Antibody

HPA037929 HPA037930

Interaction Protein

ENSG00000077549ENSG00000088038ENSG00000111596ENSG00000113300ENSG00000138767ENSG00000158435ENSG00000198791

Interaction Count

Interaction Dataset

biogrid_opencellbiogrid_bioplexintact_biogridintact_biogrid_bioplex