Protein detail

PHAR1

Phosphatase and actin regulator 1

Entry name PHAR1	UniProt ID Q9C0D0	EVMP score 0.38
Frequency 4	Transmembrane count	Protein classification Disease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Phosphatase and actin regulator 1

Protein Class

Disease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins

Protein Function

Human disease related genes:Nervous system diseases:Epilepsy
Disease related genes
Predicted intracellular proteins

Ensembl

ENSG00000112137

Entrez Gene Symbol

PHACTR1

Gene Synonym

dJ257A7.2KIAA1733RPEL1

Gene Description

Phosphatase and actin regulator 1

Chromosome

Position

12716312-13290446

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue Specificpituitary glandCell SpecificDecidual stromal cellsSingle-Nuclei Brain SpecificastrocyteBlood Cell Specificplasmacytoid DCBlood Lineage Specificdendritic cells

Function & Pathway

Protein Function

Human disease related genes:Nervous system diseases:Epilepsy
Disease related genes
Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

Canonical Pathways

M103 Pid s1p s1p1 pathway
M155 Pid s1p meta pathway
M53 Pid integrin3 pathway

Mediation Categories

Fusion and delivery mediation

Relations & Evidence

Enzyme-Mediated Modification

2 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
PHACTR1	CDK1	P06493	T	104	phosphorylation	KEA	KEA:17570479
PHACTR1	MAPK10	P53779	T	104	phosphorylation	KEA	KEA:17570479

Ligand-Receptor Signaling

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PHAR1	Q9C0D0	PP1A	P62136	Yes	Yes	No	HPRDHINTLit-BM-17SIGNOR	SIGNOR:21939755 Lit-BM-17:15107502 HINT:32975518 HPRD:15107502 HINT:15107502

Protein Complex Composition

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	PHACTR1 SPTAN1	Q13813 Q9C0D0	2:2	PDB	PDB:6zeh
	PHACTR1	Q9C0D0	6	PDB	PDB:6zej

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Density Gradient CentrifugationSize Exclusion Chromatography	Mass spectrometry	2	34817906 28986585

Sequence, Structure & Domains

Sequences

Length

580

Mass

66,308

Sequence

MDYPKMDYFLDVESAHRLLDVESAQRFFYSQGAQARRATLLLPPTLMAASSEDDIDRRPIRRVRSKSDTPYLAEARISFNLGAAEEVERLAAMRSDSLVPGTHTPPIRRRSKFANLGRIFKPWKWRKKKSEKFKHTSAALERKISMRQSREELIKRGVLKEIYDKDGELSISNEEDSLENGQSLSSSQLSLPALSEMEPVPMPRDPCSYEVLQPSDIMDGPDPGAPVKLPCLPVKLSPPLPPKKVMICMPVGGPDLSLVSYTAQKSGQQGVAQHHHTVLPSQIQHQLQYGSHGQHLPSTTGSLPMHPSGCRMIDELNKTLAMTMQRLESSEQRVPCSTSYHSSGLHSGDGVTKAGPMGLPEIRQVPTVVIECDDNKENVPHESDYEDSSCLYTREEEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLSNRPSKRELEEKNILPRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQEEQEEKREIKRRLTRKLSQRPTVEELRERKILIRFSDYVEVADAQDYDRRADKPWTRLTAADKAAIRKELNEFKSTEMEVHELSRHLTRFHRP

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9C0D0-1; Sequence=Displayed; Name=2; IsoId=Q9C0D0-2; Sequence=VSP_018529, VSP_018530

Alternative Sequence

483..484; PR -> RK (in isoform 2); 485..580; Missing (in isoform 2)

3D Structural Models

Helix

541..543; 547..563; 569..574

Beta Strand

527..530

3D Structure

X-ray crystallography (6)

Domain & Motif Annotations

Compositional Bias

335..345; Polar residues; 395..407; Acidic residues; 471..494; Basic and acidic residues

Repeat

138..163; RPEL 1; 422..447; RPEL 2; 460..484; RPEL 3; 498..523; RPEL 4

Motif

108..129; Nuclear localization signal

Domain (CC)

Binds three actin monomers via the three C-terminal RPEL repeats.

Region

331..355; Disordered; 376..410; Disordered; 462..494; Disordered

Protein Families

Phosphatase and actin regulator family

Sequence Similarities

Belongs to the phosphatase and actin regulator family.

Clinical Relevance

Disease Involvement

Epilepsy

Antibody

HPA029755 HPA029756 HPA029757