Protein detail
PHAR1
Phosphatase and actin regulator 1
Entry name PHAR1 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 4 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Phosphatase and actin regulator 1
Protein Class (4)
Disease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins
Protein Function (3)
- Human disease related genes:Nervous system diseases:Epilepsy
- Disease related genes
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
dJ257A7.2KIAA1733RPEL1
Gene Description
Phosphatase and actin regulator 1
Chromosome
6
Position
12716312-13290446
Supporting publications (n)
4
EVMP confidence score
0.38
Fluorescence & Localization5
Tissue Specificpituitary glandCell SpecificDecidual stromal cellsSingle-Nuclei Brain SpecificastrocyteBlood Cell Specificplasmacytoid DCBlood Lineage Specificdendritic cells
Function & Pathway6
Protein Function (3)
- Human disease related genes:Nervous system diseases:Epilepsy
- Disease related genes
- Predicted intracellular proteins
Cellular Component (3)
Molecular Function (3)
Biological Process (3)
Canonical Pathways (3)
- M103 Pid s1p s1p1 pathway
- M155 Pid s1p meta pathway
- M53 Pid integrin3 pathway
Mediation Categories
Fusion and delivery mediation
Relations & Evidence11
Enzyme-Mediated Modification (2)
2 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| PHACTR1 | CDK1 | P06493 | T | 104 | phosphorylation | KEA | KEA:17570479 |
| PHACTR1 | MAPK10 | P53779 | T | 104 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling (5)
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PHAR1 | Q9C0D0 | PP1A | P62136 | Yes | Yes | No | HPRDHINTLit-BM-17SIGNOR | SIGNOR:21939755Lit-BM-17:15107502HINT:32975518HPRD:15107502HINT:15107502 |
Protein Complex Composition (2)
Sequence, Structure & Domains15
Sequences
Length
580
Mass
66,308
Sequence
MDYPKMDYFLDVESAHRLLDVESAQRFFYSQGAQARRATLLLPPTLMAASSEDDIDRRPIRRVRSKSDTPYLAEARISFNLGAAEEVERLAAMRSDSLVPGTHTPPIRRRSKFANLGRIFKPWKWRKKKSEKFKHTSAALERKISMRQSREELIKRGVLKEIYDKDGELSISNEEDSLENGQSLSSSQLSLPALSEMEPVPMPRDPCSYEVLQPSDIMDGPDPGAPVKLPCLPVKLSPPLPPKKVMICMPVGGPDLSLVSYTAQKSGQQGVAQHHHTVLPSQIQHQLQYGSHGQHLPSTTGSLPMHPSGCRMIDELNKTLAMTMQRLESSEQRVPCSTSYHSSGLHSGDGVTKAGPMGLPEIRQVPTVVIECDDNKENVPHESDYEDSSCLYTREEEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLSNRPSKRELEEKNILPRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQEEQEEKREIKRRLTRKLSQRPTVEELRERKILIRFSDYVEVADAQDYDRRADKPWTRLTAADKAAIRKELNEFKSTEMEVHELSRHLTRFHRP
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9C0D0-1; Sequence=Displayed; Name=2; IsoId=Q9C0D0-2; Sequence=VSP_018529, VSP_018530
Alternative Sequence
483..484; PR -> RK (in isoform 2); 485..580; Missing (in isoform 2)
3D Structural Models
Helix
541..543; 547..563; 569..574
Beta Strand
527..530
3D Structure
X-ray crystallography (6)
Domain & Motif Annotations
Compositional Bias
335..345; Polar residues; 395..407; Acidic residues; 471..494; Basic and acidic residues
Repeat
138..163; RPEL 1; 422..447; RPEL 2; 460..484; RPEL 3; 498..523; RPEL 4
Motif
108..129; Nuclear localization signal
Domain (CC)
Binds three actin monomers via the three C-terminal RPEL repeats.
Region
331..355; Disordered; 376..410; Disordered; 462..494; Disordered
Protein Families
Phosphatase and actin regulator family
Sequence Similarities
Belongs to the phosphatase and actin regulator family.
Supporting Publications4
| PMID | Title | Abstract |
|---|---|---|
| 33936570 | Quantitative proteomic analysis of extracellular vesicle subgroups isolated by an optimized method combining polymer-based precipitation and size exclusion chromatography. | No abstract available |
| 36146834 | Human Cytomegalovirus Modifies Placental Small Extracellular Vesicle Composition to Enhance Infection of Fetal Neural Cells In Vitro. | No abstract available |
| 38207106 | Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity. | No abstract available |
| 40189497 | Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis. | No abstract available |