Protein detail
TTYH3
Protein tweety homolog 3 (hTTY3) (Volume-regulated anion channel subunit TTYH3)
Entry name TTYH3 | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 2 | Transmembrane count 5 | Protein classification Predicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Protein tweety homolog 3 (hTTY3) (Volume-regulated anion channel subunit TTYH3)
Protein Class (2)
Predicted membrane proteinsTransporters
Protein Function
Transporters:Transporter channels and pores
Transmembrane
43..63; Helical; Name=1; 87..107; Helical; Name=2; 212..232; Helical; Name=3; 237..257; Helical; Name=4; 387..407; Helical; Name=5
Transmembrane Count
5
Ensembl
Entrez Gene Symbol
Gene Synonym
KIAA1691
Gene Description
Tweety family member 3
Chromosome
7
Position
2631961-2664802
Supporting publications (n)
2
EVMP confidence score
0.25
Fluorescence & Localization5
Tissue SpecificlungCell SpecificcDCSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificclassical monocyteBlood Lineage Specificdendritic cells
Function & Pathway6
Protein Function
Transporters:Transporter channels and pores
Cellular Component (3)
Molecular Function (5)
Biological Process (3)
Reactome (3)
Mediation Categories
Fusion and delivery mediation
Relations & Evidence32
Ligand-Receptor Signaling (27)
27 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ion_channel | ion_channel | Almen2009 | No | Yes | No | Yes | No |
| tweety_chloride | ion_channel | Almen2009 | No | Yes | No | Yes | No |
| transporter | transporter | OmniPath | No | Yes | No | Yes | No |
| ion_channel | ion_channel | OmniPath | No | Yes | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| NED4L | Q96PU5 | TTYH3 | Q9C0H2 | Yes | No | Yes | SIGNOR | SIGNOR:18577513 |
Protein Complex Composition (3)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 37886648 |
Sequence, Structure & Domains12
Sequences
Length
523
Mass
57,545
Sequence
MAGVSYAAPWWVSLLHRLPHFDLSWEATSSQFRPEDTDYQQALLLLGAAALACLALDLLFLLFYSFWLCCRRRKSEEHLDADCCCTAWCVIIATLVCSAGIAVGFYGNGETSDGIHRATYSLRHANRTVAGVQDRVWDTAVGLNHTAEPSLQTLERQLAGRPEPLRAVQRLQGLLETLLGYTAAIPFWRNTAVSLEVLAEQVDLYDWYRWLGYLGLLLLDVIICLLVLVGLIRSSKGILVGVCLLGVLALVISWGALGLELAVSVGSSDFCVDPDAYVTKMVEEYSVLSGDILQYYLACSPRAANPFQQKLSGSHKALVEMQDVVAELLRTVPWEQPATKDPLLRVQEVLNGTEVNLQHLTALVDCRSLHLDYVQALTGFCYDGVEGLIYLALFSFVTALMFSSIVCSVPHTWQQKRGPDEDGEEEAAPGPRQAHDSLYRVHMPSLYSCGSSYGSETSIPAAAHTVSNAPVTEYMSQNANFQNPRCENTPLIGRESPPPSYTSSMRAKYLATSQPRPDSSGSH
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9C0H2-1; Sequence=Displayed; Name=2; IsoId=Q9C0H2-2; Sequence=VSP_029770; Name=3; IsoId=Q9C0H2-3; Sequence=VSP_029769; Name=4; IsoId=Q9C0H2-4; Sequence=VSP_042220
Alternative Sequence
1..208; MAGVSYAAPWWVSLLHRLPHFDLSWEATSSQFRPEDTDYQQALLLLGAAALACLALDLLFLLFYSFWLCCRRRKSEEHLDADCCCTAWCVIIATLVCSAGIAVGFYGNGETSDGIHRATYSLRHANRTVAGVQDRVWDTAVGLNHTAEPSLQTLERQLAGRPEPLRAVQRLQGLLETLLGYTAAIPFWRNTAVSLEVLAEQVDLYDWY -> MPSGVPGCWPQLPLKGPWRPTPRPRVPVPWRTPRFAC (in isoform 3); 210..241; Missing (in isoform 2); 501..523; YTSSMRAKYLATSQPRPDSSGSH -> RYLAALDSGSHAGWQFKPMDSARTLW (in isoform 4)
3D Structural Models
Helix
10..16; 37..65; 88..157; 162..184; 195..233; 236..272; 274..284; 290..298; 308..335; 337..339; 340..363; 366..408; 409..411
3D Structure
Electron microscopy (2)
Domain & Motif Annotations
Compositional Bias
501..523; Polar residues
Motif
498..501; PY-motif; mediates interaction with NEDD4L
Region
413..435; Disordered; 482..523; Disordered
Protein Families
Tweety family
Sequence Similarities
Belongs to the tweety family.
Clinical Relevance1
Antibody
Supporting Publications2
| PMID | Title | Abstract |
|---|---|---|
| 32396726 | Plasma-Derived Extracellular Vesicle Phosphoproteomics through Chemical Affinity Purification. | No abstract available |
| 35029059 | Human neural cell type-specific extracellular vesicle proteome defines disease-related molecules associated with activated astrocytes in Alzheimer's disease brain. | No abstract available |