Protein detail

S39A8

Metal cation symporter ZIP8 (BCG-induced integral membrane protein in monocyte clone 103 protein) (LIV-1 subfamily of ZIP zinc transporter 6) (LZT-Hs6) (Solute carrier family 39 member 8) (Zrt- and Irt-like protein 8) (ZIP-8)

Entry name
S39A8
UniProt ID
Q9C0K1
EVMP confidence score
0.40
Supporting publications (n)
1
Transmembrane count
6
Protein classification
Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters
Basic Information
Protein Names
Metal cation symporter ZIP8 (BCG-induced integral membrane protein in monocyte clone 103 protein) (LIV-1 subfamily of ZIP zinc transporter 6) (LZT-Hs6) (Solute carrier family 39 member 8) (Zrt- and Irt-like protein 8) (ZIP-8)
Protein Class (6)
Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters
Protein Function (4)
  • Transporters:Electrochemical Potential-driven transporters
  • Disease related genes
  • Human disease related genes:Congenital disorders of metabolism:Congenital disorders of glycan/glycoprotein metabolism
  • Potential drug targets
Transmembrane
133..153; Helical; 161..181; Helical; 192..212; Helical; 366..386; Helical; 389..409; Helical; 430..450; Helical
Transmembrane Count
6
Ensembl
ENSG00000138821
Entrez Gene Symbol
SLC39A8
Gene Synonym
BIGM103
Gene Description
Solute carrier family 39 member 8
Chromosome
4
Position
102251080-102431258
Supporting publications (n)
1
EVMP confidence score
0.40
Fluorescence & Localization
Tissue Specificlymphoid tissueCell SpecificcDCSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificeosinophilSecretome LocationIntracellular and membraneSecretome FunctionCell adhesion
Function & Pathway
Protein Function (4)
  • Transporters:Electrochemical Potential-driven transporters
  • Disease related genes
  • Human disease related genes:Congenital disorders of metabolism:Congenital disorders of glycan/glycoprotein metabolism
  • Potential drug targets
Cellular Component (5)
Molecular Function (3)
Biological Process (3)
KEGG (3)
Reactome (5)
Mediation Categories
Fusion and delivery mediation
Relations & Evidence27

Enzyme-Mediated Modification (1)

1 record.

Substrate Gene SymbolEnzyme Gene SymbolEnzyme UniProt IDResidue TypeResidue OffsetModificationDatabaseReferences
SLC39A8PRKCAP17252T424phosphorylationKEAKEA:17570479

Ligand-Receptor Signaling (23)

23 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
transmembranetransmembraneUniProt_topology
transmembranetransmembraneUniProt_keyword
transmembranetransmembraneLOCATE
transmembranetransmembraneRamilowski_location
transmembranetransmembraneOmniPath
plasma_membraneplasma_membraneUniProt_location
basolateral_cell_membraneplasma_membraneUniProt_location
apical_cell_membraneplasma_membraneUniProt_location
plasma_membraneplasma_membraneOmniPath
cell_surfacecell_surfaceSurfaceome
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Protein Complex Composition (2)

2 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
GPD2SLC39A8TAOK2P43304Q9C0K1Q9UL540:0:0hu.MAP2
SLC39A8TAOK2Q9C0K1Q9UL540:0hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationDensity Gradient CentrifugationSize Exclusion ChromatographyMass spectrometry83481790628986585278941043994804038321535400890673370951030646616
Sequence, Structure & Domains

Sequences

Length
460
Mass
49,631
Sequence
MAPGRAVAGLLLLAAAGLGGVAEGPGLAFSEDVLSVFGANLSLSAAQLQHLLEQMGAASRVGVPEPGQLHFNQCLTAEEIFSLHGFSNATQITSSKFSVICPAVLQQLNFHPCEDRPKHKTRPSHSEVWGYGFLSVTIINLASLLGLILTPLIKKSYFPKILTFFVGLAIGTLFSNAIFQLIPEAFGFDPKVDSYVEKAVAVFGGFYLLFFFERMLKMLLKTYGQNGHTHFGNDNFGPQEKTHQPKALPAINGVTCYANPAVTEANGHIHFDNVSVVSLQDGKKEPSSCTCLKGPKLSEIGTIAWMITLCDALHNFIDGLAIGASCTLSLLQGLSTSIAILCEEFPHELGDFVILLNAGMSTRQALLFNFLSACSCYVGLAFGILVGNNFAPNIIFALAGGMFLYISLADMFPEMNDMLREKVTGRKTDFTFFMIQNAGMLTGFTAILLITLYAGEIELE
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9C0K1-1; Sequence=Displayed; Name=2; IsoId=Q9C0K1-2; Sequence=VSP_029884, VSP_029885; Name=3; IsoId=Q9C0K1-3; Sequence=VSP_043675
Alternative Sequence
1..67; Missing (in isoform 2); 68..72; QLHFN -> MHQHA (in isoform 2); 423..460; VTGRKTDFTFFMIQNAGMLTGFTAILLITLYAGEIELE -> IIKWATDDIKSQLHLLWIYTAR (in isoform 3)

Domain & Motif Annotations

Motif
343..348; XEXPHE-motif
Protein Families
ZIP transporter (TC 2.A.5) family
Sequence Similarities
Belongs to the ZIP transporter (TC 2.A.5) family.
Clinical Relevance
Disease Involvement
Congenital disorder of glycosylation
Related Diseases
Congenital disorder of glycosylation
Drugs
DEHYDRATED ALCOHOL
Antibody (2)
HPA038832HPA038833
Supporting Publications1
PMIDTitleRelated sentences
37941517Engineered Extracellular Vesicles Expressing Siglec-10 Camouflaged AIE Photosensitizer to Reprogram Macrophages to Active M1 Phenotype and Present Tumor-Associated Antigens for Photodynamic Immunotherapy.Engineered extracellular vesicles (EVs) that express ICs Siglec-10 are first obtained from 4T1 tumor cells.