Protein detail
WDR12
Ribosome biogenesis protein WDR12 (WD repeat-containing protein 12)
Protein symbol WDR12 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Essential proteinsPlasma proteinsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Ribosome biogenesis protein WDR12 (WD repeat-containing protein 12)
Protein Class
Essential proteinsPlasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
FLJ10881YTM1
Gene Description
WD repeat domain 12
Chromosome
2
Position
202874261-203014798
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificbone marrowCell SpecificcDCSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificclassical monocyteBlood Lineage Specificdendritic cells
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Other mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 40326690 |
Sequence, Structure & Domains
Sequences
Length
423
Mass
47,708
Sequence
MAQLQTRFYTDNKKYAVDDVPFSIPAASEIADLSNIINKLLKDKNEFHKHVEFDFLIKGQFLRMPLDKHMEMENISSEEVVEIEYVEKYTAPQPEQCMFHDDWISSIKGAEEWILTGSYDKTSRIWSLEGKSIMTIVGHTDVVKDVAWVKKDSLSCLLLSASMDQTILLWEWNVERNKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVPTDEEDEMEESTNRPRKKQKTEQLGLTRTPIVTLSGHMEAVSSVLWSDAEEICSASWDHTIRVWDVESGSLKSTLTGNKVFNCISYSPLCKRLASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNIVKLWDTRSCKAPLYDLAAHEDKVLSVDWTDTGLLLSGGADNKLYSYRYSPTTSHVGA
3D Structural Models
Turn
174..177; 285..288; 307..310; 329..332
Helix
13..15; 30..44; 66..72
Beta Strand
4..9; 22..24; 53..57; 77..79; 81..87; 96..99; 104..109; 111..118; 123..127; 132..136; 143..150; 153..162; 167..173; 178..185; 192..197; 201..208; 213..217; 244..247; 250..253; 260..275; 278..284; 289..295; 300..306; 311..324; 333..339; 345..350; 355..362; 367..371; 379..382; 389..394; 398..404; 407..413
3D Structure
Electron microscopy (1); X-ray crystallography (2)
Domain & Motif Annotations
Repeat
99..137; WD 1; 138..180; WD 2; 187..226; WD 3; 255..293; WD 4; 295..334; WD 5; 340..380; WD 6; 384..422; WD 7
Region
4..87; Ubiquitin-like (UBL) domain; 98..423; Sufficient for nucleolar localization; 220..242; Disordered
Protein Families
WD repeat WDR12/YTM1 family
Sequence Similarities
Belongs to the WD repeat WDR12/YTM1 family.
Clinical Relevance
Antibody
Interaction Protein
ENSG00000100029ENSG00000101266ENSG00000107833ENSG00000124228ENSG00000181163
Interaction Count
5
Interaction Dataset
intact_biogrid_opencellbiogrid_opencellbiogrid_opencell_bioplex