Protein detail
WDR12
Ribosome biogenesis protein WDR12 (WD repeat-containing protein 12)
Entry name WDR12 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Essential proteinsPlasma proteinsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Ribosome biogenesis protein WDR12 (WD repeat-containing protein 12)
Protein Class (3)
Essential proteinsPlasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
FLJ10881YTM1
Gene Description
WD repeat domain 12
Chromosome
2
Position
202874261-203014798
Supporting publications (n)
1
EVMP confidence score
0.38
Fluorescence & Localization6
Tissue Specificbone marrowCell SpecificcDCSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificclassical monocyteBlood Lineage Specificdendritic cells
Function & Pathway6
Protein Function
Predicted intracellular proteins
Cellular Component (4)
Molecular Function (2)
Biological Process (3)
Mediation Categories
Other mediation
Relations & Evidence6
Ligand-Receptor Signaling (5)
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 40326690 |
Sequence, Structure & Domains11
Sequences
Length
423
Mass
47,708
Sequence
MAQLQTRFYTDNKKYAVDDVPFSIPAASEIADLSNIINKLLKDKNEFHKHVEFDFLIKGQFLRMPLDKHMEMENISSEEVVEIEYVEKYTAPQPEQCMFHDDWISSIKGAEEWILTGSYDKTSRIWSLEGKSIMTIVGHTDVVKDVAWVKKDSLSCLLLSASMDQTILLWEWNVERNKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVPTDEEDEMEESTNRPRKKQKTEQLGLTRTPIVTLSGHMEAVSSVLWSDAEEICSASWDHTIRVWDVESGSLKSTLTGNKVFNCISYSPLCKRLASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNIVKLWDTRSCKAPLYDLAAHEDKVLSVDWTDTGLLLSGGADNKLYSYRYSPTTSHVGA
3D Structural Models
Turn
174..177; 285..288; 307..310; 329..332
Helix
13..15; 30..44; 66..72
Beta Strand
4..9; 22..24; 53..57; 77..79; 81..87; 96..99; 104..109; 111..118; 123..127; 132..136; 143..150; 153..162; 167..173; 178..185; 192..197; 201..208; 213..217; 244..247; 250..253; 260..275; 278..284; 289..295; 300..306; 311..324; 333..339; 345..350; 355..362; 367..371; 379..382; 389..394; 398..404; 407..413
3D Structure
Electron microscopy (1); X-ray crystallography (2)
Domain & Motif Annotations
Repeat
99..137; WD 1; 138..180; WD 2; 187..226; WD 3; 255..293; WD 4; 295..334; WD 5; 340..380; WD 6; 384..422; WD 7
Region
4..87; Ubiquitin-like (UBL) domain; 98..423; Sufficient for nucleolar localization; 220..242; Disordered
Protein Families
WD repeat WDR12/YTM1 family
Sequence Similarities
Belongs to the WD repeat WDR12/YTM1 family.
Clinical Relevance4
Antibody
Interaction Protein (5)
ENSG00000100029ENSG00000101266ENSG00000107833ENSG00000124228ENSG00000181163
Interaction Count
5
Interaction Dataset (3)
intact_biogrid_opencellbiogrid_opencellbiogrid_opencell_bioplex
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 27605433 | Secreted primary human malignant mesothelioma exosome signature reflects oncogenic cargo. | No abstract available |