Protein detail

NMUR2

Neuromedin-U receptor 2 (NMU-R2) (G-protein coupled receptor FM-4) (G-protein coupled receptor TGR-1)

Entry name
NMUR2
UniProt ID
EVMP score
0.50
Frequency
1
Transmembrane count
7
Protein classification
G-protein coupled receptorsPredicted membrane proteins
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Neuromedin-U receptor 2 (NMU-R2) (G-protein coupled receptor FM-4) (G-protein coupled receptor TGR-1)
Protein Class
G-protein coupled receptorsPredicted membrane proteins
Protein Function
G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
50..70; Helical; Name=1; 83..103; Helical; Name=2; 124..146; Helical; Name=3; 166..186; Helical; Name=4; 215..235; Helical; Name=5; 266..286; Helical; Name=6; 302..322; Helical; Name=7
Transmembrane Count
7
Entrez Gene Symbol
Gene Synonym
NMU2R
Gene Description
Neuromedin U receptor 2
Chromosome
5
Position
152391546-152433368
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
NMUR2 fluorescence
Cell SpecificNeutrophil progenitors
Function & Pathway
Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

53 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
transmembranetransmembraneGO_IntercellNoNoNoYesNo
transmembranetransmembraneCellPhoneDBNoNoNoYesNo
transmembranetransmembraneTopDBNoNoNoYesNo
transmembranetransmembraneRamilowski_locationNoNoNoYesNo
transmembranetransmembraneOmniPathNoNoNoYesNo
plasma_membraneplasma_membraneUniProt_locationNoNoNoYesNo
plasma_membraneplasma_membraneCellinkerNoNoNoYesNo
plasma_membraneplasma_membraneOmniPathNoNoNoYesNo
plasma_membrane_transmembraneplasma_membrane_transmembraneHPMRNoNoNoYesNo
plasma_membrane_transmembraneplasma_membrane_transmembraneOmniPathNoNoNoYesNo
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Regulatory Interaction Network

9 records.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
NMSQ5H8A3NMUR2Q9GZQ4YesYesNoiTALKGuide2Pharma_LRdbSIGNORHINTHPMR_talklrCellChatDBtalklrscConnectRamilowski2015_Baccin2019Guide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrBaccin2019CellinkerSTRING_talklrGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdbCellTalkDB:15635449Baccin2019:1563544915635440Cellinker:15635449CellChatDB:29288685HINT:35440625scConnect:15635449LRdb:15635449connectomeDB2020:15635449Cellinker:29288685SIGNOR:15635449Guide2Pharma:15635449
NMUR2Q9GZQ4GNAQP50148YesYesNoSIGNORSIGNOR:31160049
NMUR2Q9GZQ4GNA15P30679YesYesNoSIGNORSIGNOR:31160049
NMUR2Q9GZQ4GNAZP19086YesYesNoSIGNORSIGNOR:31160049
NMUR2Q9GZQ4GNAI3P08754YesYesNoSIGNORSIGNOR:31160049
NMUR2Q9GZQ4GNA14O95837YesYesNoSIGNORSIGNOR:31160049
NMUR2Q9GZQ4GNAOP09471YesYesNoSIGNORSIGNOR:31160049
NMUR2Q9GZQ4GNAI1P63096YesYesNoHINTSIGNORHINT:36575163SIGNOR:31160049
NMUR2Q9GZQ4GNA12Q03113YesYesNoSIGNORSIGNOR:31160049

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyWestern BlottingMass SpectrometryElisa137204515
Sequence, Structure & Domains

Sequences

Length
415
Mass
47,696
Sequence
MSGMEKLQNASWIYQQKLEDPFQKHLNSTEEYLAFLCGPRRSHFFLPVSVVYVPIFVVGVIGNVLVCLVILQHQAMKTPTNYYLFSLAVSDLLVLLLGMPLEVYEMWRNYPFLFGPVGCYFKTALFETVCFASILSITTVSVERYVAILHPFRAKLQSTRRRALRILGIVWGFSVLFSLPNTSIHGIKFHYFPNGSLVPGSATCTVIKPMWIYNFIIQVTSFLFYLLPMTVISVLYYLMALRLKKDKSLEADEGNANIQRPCRKSVNKMLFVLVLVFAICWAPFHIDRLFFSFVEEWSESLAAVFNLVHVVSGVFFYLSSAVNPIIYNLLSRRFQAAFQNVISSFHKQWHSQHDPQLPPAQRNIFLTECHFVELTEDIGPQFPCQSSMHNSHLPAALSSEQMSRTNYQSFHFNKT

3D Structural Models

Turn
256..258
Helix
45..72; 74..76; 79..107; 116..149; 151..157; 160..183; 210..224; 226..244; 247..249; 259..293; 299..327; 332..345
Beta Strand
185..187; 193..197; 204..206; 329..331
3D Structure
Electron microscopy (3)

Domain & Motif Annotations

Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance