Protein detail
S22A4
Solute carrier family 22 member 4 (Ergothioneine transporter) (ET transporter) (ETTh) (Organic cation/carnitine transporter 1) (OCTN1)
Protein symbol S22A4 | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 12 | Protein classification Disease related genesHuman disease related genesMetabolic proteinsPredicted membrane proteins |
Basic Information
Protein Names
Solute carrier family 22 member 4 (Ergothioneine transporter) (ET transporter) (ETTh) (Organic cation/carnitine transporter 1) (OCTN1)
Protein Class
Disease related genesHuman disease related genesMetabolic proteinsPredicted membrane proteins
Protein Function
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- Disease related genes
- Human disease related genes:Immune system diseases:Other immune system diseases
Transmembrane
21..41; Helical; Name=1; 142..162; Helical; Name=2; 172..192; Helical; Name=3; 198..218; Helical; Name=4; 233..253; Helical; Name=5; 258..278; Helical; Name=6; 338..358; Helical; Name=7; 372..392; Helical; Name=8; 400..420; Helical; Name=9; 427..447; Helical; Name=10; 461..481; Helical; Name=11; 487..507; Helical; Name=12
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Gene Synonym
DFNB60MGC34546OCTN1
Gene Description
Solute carrier family 22 member 4
Chromosome
5
Position
132294394-132344190
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Cell SpecificCone photoreceptor cellsBlood Cell Specificintermediate monocyteBlood Lineage Specificmonocytes
Function & Pathway
Protein Function
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- Disease related genes
- Human disease related genes:Immune system diseases:Other immune system diseases
Cellular Component
Molecular Function
- GO:0005277 acetylcholine transmembrane transporter activity
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0008513 secondary active organic cation transmembrane transporter activity
- GO:0015171 amino acid transmembrane transporter activity
- GO:0015199 amino-acid betaine transmembrane transporter activity
- GO:0015226 carnitine transmembrane transporter activity
- GO:0015293 symporter activity
- GO:0015651 quaternary ammonium group transmembrane transporter activity
- GO:0030165 PDZ domain binding
Biological Process
Reactome
Mediation Categories
Clinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
26 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| slc22 | transporter | Surfaceome | No | Yes | No | No | No |
| slc | transporter | Surfaceome | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| basal_cell_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
551
Mass
62,155
Sequence
MRDYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAANLSSAWRNNSVPLRLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQTGFSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQKAAKMNNIAVPAVIFDSVEELNPLKQQKAFILDLFRTRNIAIMTIMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQKVKWFRSGKKTRDSMETEENPKVLITAF
3D Structural Models
Domain & Motif Annotations
Protein Families
- Major facilitator (TC 2.A.1) superfamily
- Organic cation transporter (TC 2.A.1.19) family
Sequence Similarities
Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Clinical Relevance
Disease Involvement
Disease variant