Protein detail

ENKD1

Enkurin domain-containing protein 1

Entry name ENKD1	UniProt ID Q9H0I2	EVMP confidence score 0.38
Supporting publications (n) 2	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Enkurin domain-containing protein 1

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000124074

Entrez Gene Symbol

ENKD1

Gene Synonym (3)

C16orf48DKFZP434A1319FBB11

Gene Description

Enkurin domain containing 1

Chromosome

Position

67662945-67667265

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization3

Cell SpecificBergmann gliaBlood Cell Specificbasophil

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (8)

Molecular Function (3)

Biological Process (3)

Canonical Pathways (3)

M26 Pid nfkappab atypical pathway
M251 Pid syndecan 3 pathway
M273 Pid epha2 fwd pathway

Mediation Categories

Other mediation

Relations & Evidence6

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	ENKD1 MAGEC1 SUV39H1	O43463 O60732 Q9H0I2	0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Western blottingELISA	4	41227296 38731868 40784529 37922300

Sequence, Structure & Domains8

Sequences

Length

346

Mass

38,759

Sequence

MCEGPSRISGPIPPDPTLCPDNYRRPTSAQGRLEGNALKLDLLTSDRALDTTAPRGPCIGPGAGEILERGQRGVGDVLLQLEGISLGPGASLKRKDPKDHEKENLRRIREIQKRFREQERSREQGQPRPLKALWRSPKYDKVESRVKAQLQEPGPASGTESAHFLRAHSRCGPGLPPPHVSSPQPTPPGPEAKEPGLGVDFIRHNARAAKRAPRRHSCSLQVLAQVLEQQRQAQEHYNATQKGHVPHYLLERRDLWRREAEARKQSQPDPAMPPGHTRMPENQRLETLTKLLQSQSQLLRELVLLPAGADSLRAQSHRAELDRKLVQVEEAIKIFSRPKVFVKMDD

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9H0I2-1; Sequence=Displayed; Name=2; IsoId=Q9H0I2-2; Sequence=VSP_021904, VSP_021905

Alternative Sequence

1..118; Missing (in isoform 2); 119..149; ERSREQGQPRPLKALWRSPKYDKVESRVKAQ -> MDAKVRRAKMARVLQLEPQTSACLLSLLCPA (in isoform 2)

Domain & Motif Annotations

Compositional Bias

114..125; Basic and acidic residues; 174..190; Pro residues

Domain (FT)

251..343; Enkurin

Region

1..35; Disordered; 91..171; Required for binding to microtubules; 114..137; Disordered; 167..197; Disordered; 260..280; Disordered

Clinical Relevance4

Antibody (2)

HPA041163 HPA041478

Interaction Protein (5)

ENSG00000075702ENSG00000108953ENSG00000112559ENSG00000114107ENSG00000240694

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications2

PMID	Title	Abstract
38343172	Analysis of secreted small extracellular vesicles from activated human microglial cell lines reveals distinct pro- and anti-inflammatory proteomic profiles.	No abstract available
40222457	Proteome alterations in peripheral immune cells of DLBCL patients and evidence of cancer extracellular vesicles involvement.	No abstract available