Protein detail
WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 2.3.2.26) (Atrophin-1-interacting protein 5) (AIP5) (HECT-type E3 ubiquitin transferase WWP1) (TGIF-interacting ubiquitin ligase 1) (Tiul1) (WW domain-containing protein 1)
Protein symbol WWP1 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification EnzymesMetabolic proteinsPredicted intracellular proteinsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 2.3.2.26) (Atrophin-1-interacting protein 5) (AIP5) (HECT-type E3 ubiquitin transferase WWP1) (TGIF-interacting ubiquitin ligase 1) (Tiul1) (WW domain-containing protein 1)
Protein Class
EnzymesMetabolic proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- ENZYME proteins:Transferases
- Enzymes
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
AIP5DKFZP434D2111
Gene Description
WW domain containing E3 ubiquitin protein ligase 1
Chromosome
8
Position
86342547-86478420
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificlymphoid tissueBrain Regional Specificcerebral cortexCell SpecificB-cellsSingle-Nuclei Brain SpecificleukocyteBlood Cell Specificmemory B-cellBlood Lineage SpecificB-cellsSecretome LocationSecreted to bloodSecretome FunctionReceptor
Function & Pathway
Protein Function
- ENZYME proteins:Transferases
- Enzymes
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
- R-hsa-1280218 adaptive immune system
- R-hsa-983168 antigen processing ubiquitination proteasome degradation
- R-hsa-983169 class i mhc mediated antigen processing presentation
- R-hsa-1253288 downregulation of erbb4 signaling
- R-hsa-983712 ion channel transport
- R-hsa-8939902 regulation of runx2 expression and activity
- R-hsa-73857 rna polymerase ii transcription
- R-hsa-1236394 signaling by erbb4
- R-hsa-9006934 signaling by receptor tyrosine kinases
- R-hsa-2672351 stimuli sensing channels
- R-hsa-8878166 transcriptional regulation by runx2
- R-hsa-382551 transport of small molecules
Canonical Pathways
- M290 Pid il12 stat4 pathway
- M88 Pid cd8 tcr pathway
- M34 Pid tcr pathway
Mediation Categories
Fusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
8 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
148 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| COMPLEX:P0CG47_P60604 | WWP1 | Q9H0M0 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P62253_P62987 | WWP1 | Q9H0M0 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P62987_Q13404 | WWP1 | Q9H0M0 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P62987_Q16763 | WWP1 | Q9H0M0 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P0CG47_P62256 | WWP1 | Q9H0M0 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P0CG48_Q13404 | WWP1 | Q9H0M0 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P0CG48_Q96B02 | WWP1 | Q9H0M0 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P0CG47_Q5VVX9 | WWP1 | Q9H0M0 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P62987_Q9NPD8 | WWP1 | Q9H0M0 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P62979_P63279 | WWP1 | Q9H0M0 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 |
Protein Complex Composition
8 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| HIVEP3-RUNX2-WWP1 complex | HIVEP3RUNX2WWP1 | Q13950Q5T1R4Q9H0M0 | 0:0:0 | CORUM | CORUM:7386 | 16728642 |
| Ub:HECT_E3 | UBBWWP1 | P0CG47Q9H0M0 | 0:0 | SIGNOR | SIGNOR:SIGNOR-C518 | |
| Ub:HECT_E3 | UBCWWP1 | P0CG48Q9H0M0 | 0:0 | SIGNOR | SIGNOR:SIGNOR-C518 | |
| Ub:HECT_E3 | RPS27AWWP1 | P62979Q9H0M0 | 0:0 | SIGNOR | SIGNOR:SIGNOR-C518 | |
| Ub:HECT_E3 | UBA52WWP1 | P62987Q9H0M0 | 1:1 | SIGNORPDB | PDB:5hpsSIGNOR:SIGNOR-C518 | |
| ARRDC2PRKAA1PRKAA2PRKAB1PRKAB2PRKAG1PRKAG2PRKAG3ULK1ULK2WWP1YWHAQ | O43741O75385P27348P54619P54646Q13131Q8IYT8Q8TBH0Q9H0M0Q9UGI9Q9UGJ0Q9Y478 | 1:1:1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC7289 | ||
| UBA52UBE2L3WWP1 | P62987P68036Q9H0M0 | 3:2:3 | PDB | PDB:5hpt | ||
| WWP1 | Q9H0M0 | 2 | PDB | PDB:6j1yPDB:9eqk |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | R SequencingMass spectrometry | 1 | 27605433 |
Sequence, Structure & Domains
Sequences
Length
922
Mass
105,202
Sequence
MATASPRSDTSNNHSGRLQLQVTVSSAKLKRKKNWFGTAIYTEVVVDGEITKTAKSSSSSNPKWDEQLTVNVTPQTTLEFQVWSHRTLKADALLGKATIDLKQALLIHNRKLERVKEQLKLSLENKNGIAQTGELTVVLDGLVIEQENITNCSSSPTIEIQENGDALHENGEPSARTTARLAVEGTNGIDNHVPTSTLVQNSCCSYVVNGDNTPSSPSQVAARPKNTPAPKPLASEPADDTVNGESSSFAPTDNASVTGTPVVSEENALSPNCTSTTVEDPPVQEILTSSENNECIPSTSAELESEARSILEPDTSNSRSSSAFEAAKSRQPDGCMDPVRQQSGNANTETLPSGWEQRKDPHGRTYYVDHNTRTTTWERPQPLPPGWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRYLYSASMLAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQGLQNEEPLPEGWEIRYTREGVRYFVDHNTRTTTFKDPRNGKSSVTKGGPQIAYERGFRWKLAHFRYLCQSNALPSHVKINVSRQTLFEDSFQQIMALKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRHYTRNSKQIIWFWQFVKETDNEVRMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE
Alternative Products
Event=Alternative splicing; Named isoforms=6; Comment=Additional isoforms seem to exist.; Name=1; Synonyms=A; IsoId=Q9H0M0-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=Q9H0M0-2; Sequence=VSP_007601, VSP_007603; Name=3; Synonyms=C; IsoId=Q9H0M0-3; Sequence=VSP_007602; Name=4; Synonyms=D; IsoId=Q9H0M0-4; Sequence=Not described; Name=5; Synonyms=E; IsoId=Q9H0M0-5; Sequence=Not described; Name=6; Synonyms=F; IsoId=Q9H0M0-6; Sequence=VSP_007600
Alternative Sequence
23..240; Missing (in isoform 6); 112..242; LERVKEQLKLSLENKNGIAQTGELTVVLDGLVIEQENITNCSSSPTIEIQENGDALHENGEPSARTTARLAVEGTNGIDNHVPTSTLVQNSCCSYVVNGDNTPSSPSQVAARPKNTPAPKPLASEPADDTV -> F (in isoform 3); 112..120; LERVKEQLK -> CWLLKARME (in isoform 2); 121..922; Missing (in isoform 2)
3D Structural Models
Turn
402..404; 427..429; 430..432; 477..480; 509..511; 517..520; 527..529; 573..575; 601..603; 749..751; 766..769
Helix
414..423; 434..443; 445..448; 487..490; 547..559; 576..586; 589..593; 611..623; 626..628; 645..649; 653..669; 680..686; 693..699; 701..712; 715..718; 743..745; 752..765; 770..783; 786..791; 794..802; 809..814; 826..837; 840..851; 860..863; 889..891; 902..914
Beta Strand
387..391; 397..401; 407..410; 452..455; 462..466; 472..476; 481..485; 502..506; 512..516; 521..525; 564..571; 594..600; 629..636; 641..643; 723..730; 733..740; 817..820; 867..870; 874..876; 881..883; 886..888; 893..895
3D Structure
NMR spectroscopy (1); X-ray crystallography (7)
Domain & Motif Annotations
Compositional Bias
210..219; Polar residues; 243..278; Polar residues; 286..302; Polar residues; 314..323; Polar residues; 340..351; Polar residues
Domain (CC)
The WW domains mediate interaction with PPxY motif-containing proteins.
Domain (FT)
1..116; C2; 349..382; WW 1; 381..414; WW 2; 456..489; WW 3; 496..529; WW 4; 588..922; HECT
Region
210..388; Disordered; 349..531; Required for interaction with and ubiquitination of AMOTL2. Required for interaction with YAP1
Clinical Relevance
Antibody
Interaction Protein
ENSG00000111605ENSG00000113369ENSG00000135063ENSG00000166949ENSG00000197070
Interaction Count
5
Interaction Dataset
intact_biogrid