Protein detail

PHS2

Pterin-4-alpha-carbinolamine dehydratase 2 (PHS 2) (EC 4.2.1.96) (4-alpha-hydroxy-tetrahydropterin dehydratase 2) (DcoH-like protein DCoHm) (Dimerization cofactor of hepatocyte nuclear factor 1 from muscle) (HNF-1-alpha dimerization cofactor)

Entry name
PHS2
UniProt ID
Q9H0N5
EVMP confidence score
0.40
Supporting publications (n)
1
Transmembrane count
Protein classification
EnzymesMetabolic proteinsPredicted intracellular proteins
Basic Information
Protein Names
Pterin-4-alpha-carbinolamine dehydratase 2 (PHS 2) (EC 4.2.1.96) (4-alpha-hydroxy-tetrahydropterin dehydratase 2) (DcoH-like protein DCoHm) (Dimerization cofactor of hepatocyte nuclear factor 1 from muscle) (HNF-1-alpha dimerization cofactor)
Protein Class (3)
EnzymesMetabolic proteinsPredicted intracellular proteins
Protein Function (3)
  • Enzymes
  • Predicted intracellular proteins
  • ENZYME proteins:Lyases
Ensembl
ENSG00000132570
Entrez Gene Symbol
PCBD2
Gene Synonym (2)
DCOH2DCOHM
Gene Description
Pterin-4 alpha-carbinolamine dehydratase 2
Chromosome
5
Position
134905120-135007959
Supporting publications (n)
1
EVMP confidence score
0.40
Fluorescence & Localization
Tissue Specificchoroid plexusBrain Regional Specificchoroid plexusCell SpecificChoroid plexus epithelial cellsSingle-Nuclei Brain SpecificpericyteBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function (3)
  • Enzymes
  • Predicted intracellular proteins
  • ENZYME proteins:Lyases
Cellular Component (3)
Molecular Function (4)
Biological Process (3)
KEGG (2)
Canonical Pathways (2)
  • M177 Pid epha fwdpathway
  • M62 Pid ephb fwd pathway
Mediation Categories
Other mediation
Relations & Evidence8

Ligand-Receptor Signaling (4)

4 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularLOCATE
intracellularintracellularComPPI
intracellularintracellularGO_Intercell
intracellularintracellularOmniPath

Protein Complex Composition (3)

3 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
BTBD10BUB1BBUB3CDC20KCTD20PCBD1PCBD2O43684O60566P61457Q12834Q7Z5Y7Q9BSF8Q9H0N50:0:0:0:0:0:0hu.MAP
ADSLAKR1E2BLMHGDAPCBD2QDPRURODP06132P09417P30566Q13867Q96JD6Q9H0N5Q9Y2T30:0:0:0:0:0:0hu.MAP2
CKBCKMNPEPPSPCBD2P06732P12277P55786Q9H0N50:0:0:0hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationMass spectrometry3250375673770475038321007
Sequence, Structure & Domains

Sequences

Length
130
Mass
14,365
Sequence
MAAVLGALGATRRLLAALRGQSLGLAAMSSGTHRLTAEERNQAILDLKAAGWSELSERDAIYKEFSFHNFNQAFGFMSRVALQAEKMNHHPEWFNVYNKVQITLTSHDCGELTKKDVKLAKFIEKAAASV

3D Structural Models

Turn
107..110
Helix
37..49; 70..87; 114..128
Beta Strand
56..59; 61..66; 92..96; 99..104
3D Structure
X-ray crystallography (1)

Domain & Motif Annotations

Protein Families
Pterin-4-alpha-carbinolamine dehydratase family
Sequence Similarities
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Clinical Relevance
Antibody
HPA036428
Interaction Protein
ENSG00000166228
Interaction Count
1
Interaction Dataset
intact_biogrid_bioplex
Supporting Publications1
PMIDTitleRelated sentences
34186243A Reductionist Approach Using Primary and Metastatic Cell-Derived Extracellular Vesicles Reveals Hub Proteins Associated with Oral Cancer Prognosis.No related sentences available