Protein detail
PHS2
Pterin-4-alpha-carbinolamine dehydratase 2 (PHS 2) (EC 4.2.1.96) (4-alpha-hydroxy-tetrahydropterin dehydratase 2) (DcoH-like protein DCoHm) (Dimerization cofactor of hepatocyte nuclear factor 1 from muscle) (HNF-1-alpha dimerization cofactor)
Protein symbol PHS2 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification EnzymesMetabolic proteinsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Pterin-4-alpha-carbinolamine dehydratase 2 (PHS 2) (EC 4.2.1.96) (4-alpha-hydroxy-tetrahydropterin dehydratase 2) (DcoH-like protein DCoHm) (Dimerization cofactor of hepatocyte nuclear factor 1 from muscle) (HNF-1-alpha dimerization cofactor)
Protein Class
EnzymesMetabolic proteinsPredicted intracellular proteins
Protein Function
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Lyases
Ensembl
Entrez Gene Symbol
Gene Synonym
DCOH2DCOHM
Gene Description
Pterin-4 alpha-carbinolamine dehydratase 2
Chromosome
5
Position
134905120-135007959
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificchoroid plexusBrain Regional Specificchoroid plexusCell SpecificChoroid plexus epithelial cellsSingle-Nuclei Brain SpecificpericyteBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Lyases
Cellular Component
Molecular Function
Biological Process
Canonical Pathways
- M177 Pid epha fwdpathway
- M62 Pid ephb fwd pathway
Mediation Categories
Other mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| BTBD10BUB1BBUB3CDC20KCTD20PCBD1PCBD2 | O43684O60566P61457Q12834Q7Z5Y7Q9BSF8Q9H0N5 | 0:0:0:0:0:0:0 | hu.MAP | |||
| ADSLAKR1E2BLMHGDAPCBD2QDPRUROD | P06132P09417P30566Q13867Q96JD6Q9H0N5Q9Y2T3 | 0:0:0:0:0:0:0 | hu.MAP2 | |||
| CKBCKMNPEPPSPCBD2 | P06732P12277P55786Q9H0N5 | 0:0:0:0 | hu.MAP2 |
Sequence, Structure & Domains
Sequences
Length
130
Mass
14,365
Sequence
MAAVLGALGATRRLLAALRGQSLGLAAMSSGTHRLTAEERNQAILDLKAAGWSELSERDAIYKEFSFHNFNQAFGFMSRVALQAEKMNHHPEWFNVYNKVQITLTSHDCGELTKKDVKLAKFIEKAAASV
3D Structural Models
Turn
107..110
Helix
37..49; 70..87; 114..128
Beta Strand
56..59; 61..66; 92..96; 99..104
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Protein Families
Pterin-4-alpha-carbinolamine dehydratase family
Sequence Similarities
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Clinical Relevance
Antibody
Interaction Protein
ENSG00000166228
Interaction Count
1
Interaction Dataset
intact_biogrid_bioplex