Protein detail

TM222

Transmembrane protein 222

Entry name TM222	UniProt ID Q9H0R3	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 3	Protein classification Disease related genesHuman disease related genesPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Transmembrane protein 222

Protein Class (3)

Disease related genesHuman disease related genesPredicted membrane proteins

Protein Function (2)

Disease related genes
Human disease related genes:Congenital malformations:Congenital malformations of the nervous system

Transmembrane

56..76; Helical; 165..185; Helical; 187..207; Helical

Transmembrane Count

Ensembl

ENSG00000186501

Entrez Gene Symbol

TMEM222

Gene Synonym (2)

C1orf160DKFZP564D0478

Gene Description

Transmembrane protein 222

Chromosome

Position

27322145-27336400

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization2

Tissue Specificskeletal muscleCell SpecificCardiomyocytes

Function & Pathway5

Protein Function (2)

Disease related genes
Human disease related genes:Congenital malformations:Congenital malformations of the nervous system

Cellular Component (2)

Molecular Function

GO:0005515 protein binding

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence11

Ligand-Receptor Signaling (10)

10 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane_predicted	transmembrane	OmniPath	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No
transmembrane_sosui	transmembrane_predicted	Almen2009	No	No	No	No	No

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationDensity Gradient CentrifugationSize Exclusion Chromatography	Mass spectrometryR Sequencing	4	34817906 38321535 29148239 32089743

Sequence, Structure & Domains6

Sequences

Length

208

Mass

23,230

Sequence

MAEAEGSSLLLLPPPPPPPRMAEVEAPTAAETDMKQYQGSGGVAMDVERSRFPYCVVWTPIPVLTWFFPIIGHMGICTSTGVIRDFAGPYFVSEDNMAFGKPAKYWKLDPAQVYASGPNAWDTAVHDASEEYKHRMHNLCCDNCHSHVALALNLMRYNNSTNWNMVTLCFFCLLYGKYVSVGAFVKTWLPFILLLGIILTVSLVFNLR

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9H0R3-1; Sequence=Displayed; Name=2; IsoId=Q9H0R3-2; Sequence=VSP_020090

Alternative Sequence

1..96; Missing (in isoform 2)

Domain & Motif Annotations

Region

1..26; Disordered

Clinical Relevance2

Disease Involvement (3)

Disease variantEpilepsyIntellectual disability

Antibody (2)

HPA016579 HPA059374

Supporting Publications1

PMID	Title	Abstract
21630462	Proteomic analysis of microvesicles derived from human colorectal cancer ascites.	No abstract available