Protein detail

TM222

Transmembrane protein 222

Entry name
TM222
UniProt ID
Q9H0R3
EVMP confidence score
0.28
Supporting publications (n)
1
Transmembrane count
3
Protein classification
Disease related genesHuman disease related genesPredicted membrane proteins
Basic Information
Protein Names
Transmembrane protein 222
Protein Class (3)
Disease related genesHuman disease related genesPredicted membrane proteins
Protein Function (2)
  • Disease related genes
  • Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
Transmembrane
56..76; Helical; 165..185; Helical; 187..207; Helical
Transmembrane Count
3
Ensembl
ENSG00000186501
Entrez Gene Symbol
TMEM222
Gene Synonym (2)
C1orf160DKFZP564D0478
Gene Description
Transmembrane protein 222
Chromosome
1
Position
27322145-27336400
Supporting publications (n)
1
EVMP confidence score
0.28
Fluorescence & Localization
Tissue Specificskeletal muscleCell SpecificCardiomyocytes
Function & Pathway
Protein Function (2)
  • Disease related genes
  • Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
Cellular Component (2)
Molecular Function
GO:0005515 protein binding
Biological Process (3)
Mediation Categories
Other mediation
Relations & Evidence11

Ligand-Receptor Signaling (10)

10 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularComPPI
intracellularintracellularOmniPath
transmembranetransmembraneUniProt_location
transmembranetransmembraneUniProt_topology
transmembranetransmembraneUniProt_keyword
transmembrane_predictedtransmembraneOmniPath
transmembranetransmembraneRamilowski_location
transmembranetransmembraneOmniPath
transmembranetransmembrane_predictedPhobius
transmembrane_sosuitransmembrane_predictedAlmen2009

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationDensity Gradient CentrifugationSize Exclusion ChromatographyMass spectrometryR Sequencing434817906383215352914823932089743
Sequence, Structure & Domains

Sequences

Length
208
Mass
23,230
Sequence
MAEAEGSSLLLLPPPPPPPRMAEVEAPTAAETDMKQYQGSGGVAMDVERSRFPYCVVWTPIPVLTWFFPIIGHMGICTSTGVIRDFAGPYFVSEDNMAFGKPAKYWKLDPAQVYASGPNAWDTAVHDASEEYKHRMHNLCCDNCHSHVALALNLMRYNNSTNWNMVTLCFFCLLYGKYVSVGAFVKTWLPFILLLGIILTVSLVFNLR
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9H0R3-1; Sequence=Displayed; Name=2; IsoId=Q9H0R3-2; Sequence=VSP_020090
Alternative Sequence
1..96; Missing (in isoform 2)

Domain & Motif Annotations

Region
1..26; Disordered
Clinical Relevance
Disease Involvement (3)
Disease variantEpilepsyIntellectual disability
Related Diseases (2)
EpilepsyIntellectual disability
Antibody (2)
HPA016579HPA059374
Supporting Publications1
PMIDTitleRelated sentences
21630462Proteomic analysis of microvesicles derived from human colorectal cancer ascites.No related sentences available