Protein detail
CAD19
Cadherin-19
Protein symbol CAD19 | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 1 | Protein classification Predicted intracellular proteinsPredicted membrane proteins |
Basic Information
Protein Names
Cadherin-19
Protein Class
Predicted intracellular proteinsPredicted membrane proteins
Protein Function
Predicted intracellular proteins
Transmembrane
597..617; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CDH7
Gene Description
Cadherin 19
Chromosome
18
Position
66501083-66604138
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Tissue Specificblood vesselCell SpecificDecidual stromal cellsSingle-Nuclei Brain SpecificastrocyteSecretome LocationSecreted to extracellular matrixSecretome FunctionCell adhesion
Function & Pathway
Protein Function
Predicted intracellular proteins
Molecular Function
Biological Process
Reactome
- R-hsa-418990 adherens junctions interactions
- R-hsa-1500931 cell cell communication
- R-hsa-446728 cell junction organization
- R-hsa-9764302 regulation of cdh19 expression and function
- R-hsa-9764260 regulation of expression and function of type ii classical cadherins
- R-hsa-9759476 regulation of homotypic cell cell adhesion
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
29 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane_predicted | transmembrane | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | LOCATE | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| CAD19 | Q9H159 | CTNB1 | P35222 | Yes | Yes | No | SIGNOR | SIGNOR:21255999 |
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Polymer Precipitation | Western blotting | 1 | 38731868 |
Sequence, Structure & Domains
Sequences
Length
772
Mass
87,002
Sequence
MNCYLLLRFMLGIPLLWPCLGATENSQTKKVKQPVRSHLRVKRGWVWNQFFVPEEMNTTSHHIGQLRSDLDNGNNSFQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRAVEPESEFVIKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQGQPYFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQTFDIITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDVDEPPLFLLPYYVFEVFEETPQGSFVGVVSATDPDNRKSPIRYSITRSKVFNINDNGTITTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHAPEFSQYYETYVCENAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPVFYISILIADNGIPSLTSTNTLTIHVCDCGDSGSTQTCQYQELVLSMGFKTEVIIAILICIMIIFGFIFLTLGLKQRRKQILFPEKSEDFRENIFQYDDEGGGEEDTEAFDIAELRSSTIMRERKTRKTTSAEIRSLYRQSLQVGPDSAIFRKFILEKLEEANTDPCAPPFDSLQTYAFEGTGSLAGSLSSLESAVSDQDESYDYLNELGPRFKRLACMFGSAVQSNN
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9H159-1; Sequence=Displayed; Name=2; IsoId=Q9H159-2; Sequence=VSP_047020, VSP_047021
Alternative Sequence
487..490; VIQT -> GLFF (in isoform 2); 491..772; Missing (in isoform 2)
3D Structural Models
Turn
96..98; 109..111; 188..190; 215..217; 296..298; 309..311; 322..324
Helix
64..67; 88..91; 173..175; 199..201; 285..288
Beta Strand
44..52; 60..63; 79..81; 92..94; 100..105; 114..120; 126..134; 146..153; 161..163; 176..184; 191..197; 203..209; 220..229; 231..233; 236..246; 254..256; 258..265; 273..276; 291..294; 305..307; 313..316; 326..335; 338..340; 343..353
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
3011..3020; Gly residues; 3244..3266; Low complexity; 3276..3289; Low complexity
Domain (CC)
Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
Domain (FT)
44..148; Cadherin 1; 149..256; Cadherin 2; 257..370; Cadherin 3; 371..470; Cadherin 4; 470..581; Cadherin 5
Region
2065..2094; Disordered; 2986..3040; Disordered; 3062..3082; Disordered; 3233..3298; Disordered
Clinical Relevance
Antibody