Protein detail
LPAR5
Lysophosphatidic acid receptor 5 (LPA receptor 5) (LPA-5) (G-protein coupled receptor 92) (G-protein coupled receptor 93)
Protein symbol LPAR5 | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 7 | Protein classification G-protein coupled receptorsPredicted membrane proteins |
Basic Information
Protein Names
Lysophosphatidic acid receptor 5 (LPA receptor 5) (LPA-5) (G-protein coupled receptor 92) (G-protein coupled receptor 93)
Protein Class
G-protein coupled receptorsPredicted membrane proteins
Protein Function
- G-protein coupled receptors:Lysolipids receptors
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
27..47; Helical; Name=1; 56..76; Helical; Name=2; 97..117; Helical; Name=3; 137..157; Helical; Name=4; 188..208; Helical; Name=5; 240..260; Helical; Name=6; 277..297; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym
GPR92GPR93KPG_010LPA5
Gene Description
Lysophosphatidic acid receptor 5
Chromosome
12
Position
6618835-6635960
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Tissue Specificpituitary glandCell SpecificBrain excitatory neuronsSecretome LocationSecreted - unknown locationSecretome FunctionNo annotated function
Function & Pathway
Protein Function
- G-protein coupled receptors:Lysolipids receptors
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component
Biological Process
KEGG
Reactome
Canonical Pathways
- M276 Pid fgf pathway
- M124 Pid cxcr4 pathway
Mediation Categories
Receptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
35 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | HPMR | No | Yes | No | Yes | No |
| receptor | receptor | Surfaceome | No | Yes | No | Yes | No |
| gpcr | receptor | DGIdb | No | Yes | No | Yes | No |
| gpcr | receptor | UniProt_keyword | No | Yes | No | Yes | No |
| seven_transmembrane_7tm | receptor | HPMR | No | Yes | No | Yes | No |
| 7tm_a | receptor | HPMR | No | Yes | No | Yes | No |
| purinergic_uridine_7tm_a | receptor | HPMR | No | Yes | No | Yes | No |
| rhodopsin | receptor | Surfaceome | No | Yes | No | Yes | No |
| gpcr | receptor | Surfaceome | No | Yes | No | Yes | No |
| class_a_rhodopsin | receptor | GPCRdb | No | Yes | No | Yes | No |
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Regulatory Interaction Network
6 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| LPAR5 | Q9H1C0 | GNAI1 | P63096 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| LPAR5 | Q9H1C0 | GNA12 | Q03113 | Yes | Yes | No | KEGG-MEDICUSSIGNOR | SIGNOR:31160049 |
| LPAR5 | Q9H1C0 | GNAZ | P19086 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| LPAR5 | Q9H1C0 | GNAI3 | P08754 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| LPAR5 | Q9H1C0 | GNAO | P09471 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| LPAR5 | Q9H1C0 | GNA13 | Q14344 | Yes | Yes | No | KEGG-MEDICUSSIGNOR | SIGNOR:31160049 |
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography | R SequencingMass spectrometry | 9 | 372050983561146237786918348179062898658530646616337095103832153533709510 |
Sequence, Structure & Domains
Sequences
Length
372
Mass
41,347
Sequence
MLANSSSTNSSVLPCPDYRPTHRLHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRDLEVRLCFESFSDELWKGRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLRSKLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTLRGLGTPHRARTSATNGTRAALAQSERSAVTTDATRPDAASQGLLRPSDSHSLSSFTQCPQDSAL
3D Structural Models
Domain & Motif Annotations
Compositional Bias
332..341; Polar residues; 357..372; Polar residues
Region
312..372; Disordered
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance
Drugs
Antibody