Protein detail

LPAR5

Lysophosphatidic acid receptor 5 (LPA receptor 5) (LPA-5) (G-protein coupled receptor 92) (G-protein coupled receptor 93)

Entry name LPAR5	UniProt ID Q9H1C0	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count 7	Protein classification G-protein coupled receptorsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Lysophosphatidic acid receptor 5 (LPA receptor 5) (LPA-5) (G-protein coupled receptor 92) (G-protein coupled receptor 93)

Protein Class (2)

G-protein coupled receptorsPredicted membrane proteins

Protein Function (2)

G-protein coupled receptors:Lysolipids receptors
G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

27..47; Helical; Name=1; 56..76; Helical; Name=2; 97..117; Helical; Name=3; 137..157; Helical; Name=4; 188..208; Helical; Name=5; 240..260; Helical; Name=6; 277..297; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000184574

Entrez Gene Symbol

LPAR5

Gene Synonym (4)

GPR92GPR93KPG_010LPA5

Gene Description

Lysophosphatidic acid receptor 5

Chromosome

Position

6618835-6635960

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization4

Tissue Specificpituitary glandCell SpecificBrain excitatory neuronsSecretome LocationSecreted - unknown locationSecretome FunctionNo annotated function

Function & Pathway8

Protein Function (2)

G-protein coupled receptors:Lysolipids receptors
G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component (2)

Molecular Function (2)

Biological Process (3)

KEGG (6)

Reactome (6)

Canonical Pathways (2)

M276 Pid fgf pathway
M124 Pid cxcr4 pathway

Mediation Categories

Receptor-signaling mediation

Relations & Evidence42

Ligand-Receptor Signaling (35)

35 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	HPMR	No	Yes	No	Yes	No
receptor	receptor	Surfaceome	No	Yes	No	Yes	No
gpcr	receptor	DGIdb	No	Yes	No	Yes	No
gpcr	receptor	UniProt_keyword	No	Yes	No	Yes	No
seven_transmembrane_7tm	receptor	HPMR	No	Yes	No	Yes	No
7tm_a	receptor	HPMR	No	Yes	No	Yes	No
purinergic_uridine_7tm_a	receptor	HPMR	No	Yes	No	Yes	No
rhodopsin	receptor	Surfaceome	No	Yes	No	Yes	No
gpcr	receptor	Surfaceome	No	Yes	No	Yes	No
class_a_rhodopsin	receptor	GPCRdb	No	Yes	No	Yes	No

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Regulatory Interaction Network (6)

6 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
LPAR5	Q9H1C0	GNAI1	P63096	Yes	Yes	No	SIGNOR	SIGNOR:31160049
LPAR5	Q9H1C0	GNA12	Q03113	Yes	Yes	No	KEGG-MEDICUSSIGNOR	SIGNOR:31160049
LPAR5	Q9H1C0	GNAZ	P19086	Yes	Yes	No	SIGNOR	SIGNOR:31160049
LPAR5	Q9H1C0	GNAI3	P08754	Yes	Yes	No	SIGNOR	SIGNOR:31160049
LPAR5	Q9H1C0	GNAO	P09471	Yes	Yes	No	SIGNOR	SIGNOR:31160049
LPAR5	Q9H1C0	GNA13	Q14344	Yes	Yes	No	KEGG-MEDICUSSIGNOR	SIGNOR:31160049

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	R SequencingMass spectrometry	9	37205098 35611462 37786918 34817906 28986585 30646616 33709510 38321535 33709510

Sequence, Structure & Domains7

Sequences

Length

372

Mass

41,347

Sequence

MLANSSSTNSSVLPCPDYRPTHRLHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVYMCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYGSCIFLMLINVDRYAAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRDLEVRLCFESFSDELWKGRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSQRRRKTVRLLLANLVIFLLCFVPYNSTLAVYGLLRSKLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFSAEGFRNTLRGLGTPHRARTSATNGTRAALAQSERSAVTTDATRPDAASQGLLRPSDSHSLSSFTQCPQDSAL

Domain & Motif Annotations

Compositional Bias

332..341; Polar residues; 357..372; Polar residues

Region

312..372; Disordered

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance2

Drugs

CHEMBL:CHEMBL1630084

Antibody

HPA013170

Supporting Publications1

PMID	Title	Abstract
22808001	Biochemical and physical characterisation of urinary nanovesicles following CHAPS treatment.	No abstract available