Protein detail

DUS15

Dual specificity protein phosphatase 15 (EC 3.1.3.16) (EC 3.1.3.48) (VH1-related member Y) (Vaccinia virus VH1-related dual-specific protein phosphatase Y)

Entry name DUS15	UniProt ID Q9H1R2	EVMP confidence score 0.50
Supporting publications (n) 4	Transmembrane count	Protein classification EnzymesPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Dual specificity protein phosphatase 15 (EC 3.1.3.16) (EC 3.1.3.48) (VH1-related member Y) (Vaccinia virus VH1-related dual-specific protein phosphatase Y)

Protein Class (2)

EnzymesPredicted intracellular proteins

Protein Function (3)

Enzymes
Predicted intracellular proteins
ENZYME proteins:Hydrolases

Ensembl

ENSG00000149599

Entrez Gene Symbol

DUSP15

Gene Synonym (5)

bA243J16.5bA243J16.6C20orf57FLJ20645VHY

Gene Description

Dual specificity phosphatase 15

Chromosome

Position

31847637-31870664

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization2

Cell SpecificHematopoietic stem cellsBlood Cell Specificeosinophil

Function & Pathway5

Protein Function (3)

Enzymes
Predicted intracellular proteins
ENZYME proteins:Hydrolases

Cellular Component (2)

Molecular Function (5)

Biological Process (3)

Mediation Categories (2)

Metabolism mediationReceptor-signaling mediation

Relations & Evidence10

Ligand-Receptor Signaling (7)

7 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	DUSP15 EIF6 GNL1 GTPBP4 MRTO4 NMD3 PA2G4 PES1 RPL12 RPL24 RPL3 RPL7A RPL8 SUMO1 UBC	O00541 P0CG48 P30050 P36915 P39023 P56537 P62424 P62917 P63165 P83731 Q96D46 Q9BZE4 Q9H1R2 Q9UKD2 Q9UQ80	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7178
	DUSP15	Q9H1R2	2	PDB	PDB:1yz4

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
	Mass spectrometry	0

Sequence, Structure & Domains13

Sequences

Length

295

Mass

31,882

Sequence

MTEGVLPGLYLGNFIDAKDLDQLGRNKITHIISIHESPQPLLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVMTVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEFGWASSQKGARHRTSKTSGAQCPPMTSATCLLAARVALLSAALVREATGRTAQRCRLSPRAAAERLLGPPPHVAAGWSPDPKYQICLCFGEEDPGPTQHPKEQLIMADVQVQLRPGSSSCTLSASTERPDGSSTPGNPDGITHLQCSCLHPKRAASSSCTR

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9H1R2-1; Sequence=Displayed; Name=2; IsoId=Q9H1R2-2; Sequence=VSP_007292, VSP_007293; Name=3; Synonyms=A; IsoId=Q9H1R2-3; Sequence=VSP_019228, VSP_007292, VSP_007293; Name=4; IsoId=Q9H1R2-4; Sequence=VSP_043107, VSP_007292, VSP_007293

Alternative Sequence

1..100; Missing (in isoform 4); 1..4; MTEG -> MGNGMTK (in isoform 3); 143..232; GARHRTSKTSGAQCPPMTSATCLLAARVALLSAALVREATGRTAQRCRLSPRAAAERLLGPPPHVAAGWSPDPKYQICLCFGEEDPGPTQ -> LRRQLEERFGESPFRDEEELRALLPLCKRCRQGSATSASSAGPHSAASEGTVQRLVPRTPREAHRPLPLLARVKQTFSCLPRCLSRKGGK (in isoform 2, isoform 3 and isoform 4); 233..295; Missing (in isoform 2, isoform 3 and isoform 4)

3D Structural Models

Helix

16..18; 20..25; 60..63; 64..76; 91..104; 108..117; 126..137; 139..146

Beta Strand

9..12; 30..34; 46..50; 81..85; 88..90

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

251..270; Polar residues

Domain (FT)

1..141; Tyrosine-protein phosphatase

Region

251..272; Disordered

Protein Families (2)

Protein-tyrosine phosphatase family
Non-receptor class dual specificity subfamily

Sequence Similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Clinical Relevance1

Antibody

HPA076649

Supporting Publications4

PMID	Title	Abstract
37922300	Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women.	No abstract available
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available
40098346	Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays.	No abstract available
41216884	Extracellular Vesicles From Multiple Sclerosis White Matter Exhibit Synaptic, Mitochondrial, Complement and Ageing-Related Pathway Dysregulation.	No abstract available