Protein detail
DUS15
Dual specificity protein phosphatase 15 (EC 3.1.3.16) (EC 3.1.3.48) (VH1-related member Y) (Vaccinia virus VH1-related dual-specific protein phosphatase Y)
Entry name DUS15 | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 4 | Transmembrane count | Protein classification EnzymesPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Dual specificity protein phosphatase 15 (EC 3.1.3.16) (EC 3.1.3.48) (VH1-related member Y) (Vaccinia virus VH1-related dual-specific protein phosphatase Y)
Protein Class (2)
EnzymesPredicted intracellular proteins
Protein Function (3)
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Ensembl
Entrez Gene Symbol
Gene Synonym (5)
bA243J16.5bA243J16.6C20orf57FLJ20645VHY
Gene Description
Dual specificity phosphatase 15
Chromosome
20
Position
31847637-31870664
Supporting publications (n)
4
EVMP confidence score
0.53
Fluorescence & Localization
Cell SpecificHematopoietic stem cellsBlood Cell Specificeosinophil
Function & Pathway
Protein Function (3)
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Cellular Component (2)
Molecular Function (5)
Biological Process (3)
Mediation Categories (2)
Metabolism mediationReceptor-signaling mediation
Relations & Evidence10
Ligand-Receptor Signaling (7)
7 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | |||||
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| plasma_membrane | plasma_membrane | UniProt_location | |||||
| plasma_membrane | plasma_membrane | OmniPath |
Protein Complex Composition (2)
2 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| DUSP15EIF6GNL1GTPBP4MRTO4NMD3PA2G4PES1RPL12RPL24RPL3RPL7ARPL8SUMO1UBC | O00541P0CG48P30050P36915P39023P56537P62424P62917P63165P83731Q96D46Q9BZE4Q9H1R2Q9UKD2Q9UQ80 | 1:1:1:1:1:1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC7178 | ||
| DUSP15 | Q9H1R2 | 2 | PDB | PDB:1yz4 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains
Sequences
Length
295
Mass
31,882
Sequence
MTEGVLPGLYLGNFIDAKDLDQLGRNKITHIISIHESPQPLLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVMTVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEFGWASSQKGARHRTSKTSGAQCPPMTSATCLLAARVALLSAALVREATGRTAQRCRLSPRAAAERLLGPPPHVAAGWSPDPKYQICLCFGEEDPGPTQHPKEQLIMADVQVQLRPGSSSCTLSASTERPDGSSTPGNPDGITHLQCSCLHPKRAASSSCTR
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9H1R2-1; Sequence=Displayed; Name=2; IsoId=Q9H1R2-2; Sequence=VSP_007292, VSP_007293; Name=3; Synonyms=A; IsoId=Q9H1R2-3; Sequence=VSP_019228, VSP_007292, VSP_007293; Name=4; IsoId=Q9H1R2-4; Sequence=VSP_043107, VSP_007292, VSP_007293
Alternative Sequence
1..100; Missing (in isoform 4); 1..4; MTEG -> MGNGMTK (in isoform 3); 143..232; GARHRTSKTSGAQCPPMTSATCLLAARVALLSAALVREATGRTAQRCRLSPRAAAERLLGPPPHVAAGWSPDPKYQICLCFGEEDPGPTQ -> LRRQLEERFGESPFRDEEELRALLPLCKRCRQGSATSASSAGPHSAASEGTVQRLVPRTPREAHRPLPLLARVKQTFSCLPRCLSRKGGK (in isoform 2, isoform 3 and isoform 4); 233..295; Missing (in isoform 2, isoform 3 and isoform 4)
3D Structural Models
Helix
16..18; 20..25; 60..63; 64..76; 91..104; 108..117; 126..137; 139..146
Beta Strand
9..12; 30..34; 46..50; 81..85; 88..90
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
251..270; Polar residues
Domain (FT)
1..141; Tyrosine-protein phosphatase
Region
251..272; Disordered
Protein Families (2)
- Protein-tyrosine phosphatase family
- Non-receptor class dual specificity subfamily
Sequence Similarities
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Clinical Relevance
Antibody
Supporting Publications4
| PMID | Title | Related sentences |
|---|---|---|
| 37922300 | Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women. | No related sentences available |
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No related sentences available |
| 40098346 | Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays. | No related sentences available |
| 41216884 | Extracellular Vesicles From Multiple Sclerosis White Matter Exhibit Synaptic, Mitochondrial, Complement and Ageing-Related Pathway Dysregulation. | No related sentences available |