Protein detail
OPN3
Opsin-3 (Encephalopsin) (Panopsin)
Entry name OPN3 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 2 | Transmembrane count 7 | Protein classification G-protein coupled receptorsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Opsin-3 (Encephalopsin) (Panopsin)
Protein Class (2)
G-protein coupled receptorsPredicted membrane proteins
Protein Function (2)
- G-protein coupled receptors:Opsins
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
41..65; Helical; Name=1; 78..102; Helical; Name=2; 118..137; Helical; Name=3; 154..177; Helical; Name=4; 202..229; Helical; Name=5; 256..279; Helical; Name=6; 288..312; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym (5)
ECPNencephalopsinERONMO-1PPP1R116
Gene Description
Opsin 3
Chromosome
1
Position
241590102-241677376
Supporting publications (n)
2
EVMP confidence score
0.38
Fluorescence & Localization5
Tissue SpecificbrainBrain Regional SpecificcerebellumCell SpecificBrain excitatory neuronsSingle-Nuclei Brain Specificupper rhombic lip
Function & Pathway6
Protein Function (2)
- G-protein coupled receptors:Opsins
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component (4)
Molecular Function (6)
Biological Process (3)
Reactome (5)
Mediation Categories (3)
Fusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence42
Ligand-Receptor Signaling (41)
41 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane | transmembrane | GO_Intercell | No | No | No | Yes | No |
| transmembrane | transmembrane | LOCATE | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
Isolation & Detection Technology (1)
Sequence, Structure & Domains7
Sequences
Length
402
Mass
44,873
Sequence
MYSGNRSGGHGYWDGGGAAGAEGPAPAGTLSPAPLFSPGTYERLALLLGSIGLLGVGNNLLVLVLYYKFQRLRTPTHLLLVNISLSDLLVSLFGVTFTFVSCLRNGWVWDTVGCVWDGFSGSLFGIVSIATLTVLAYERYIRVVHARVINFSWAWRAITYIWLYSLAWAGAPLLGWNRYILDVHGLGCTVDWKSKDANDSSFVLFLFLGCLVVPLGVIAHCYGHILYSIRMLRCVEDLQTIQVIKILKYEKKLAKMCFLMIFTFLVCWMPYIVICFLVVNGHGHLVTPTISIVSYLFAKSNTVYNPVIYVFMIRKFRRSLLQLLCLRLLRCQRPAKDLPAAGSEMQIRPIVMSQKDGDRPKKKVTFNSSSIIFIITSDESLSVDDSDKTNGSKVDVIQVRPL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=1-4b-5-6; IsoId=Q9H1Y3-1; Sequence=Displayed; Name=2; Synonyms=1-2-5-6; IsoId=Q9H1Y3-2; Sequence=VSP_010209
Alternative Sequence
126..231; IVSIATLTVLAYERYIRVVHARVINFSWAWRAITYIWLYSLAWAGAPLLGWNRYILDVHGLGCTVDWKSKDANDSSFVLFLFLGCLVVPLGVIAHCYGHILYSIRM -> WISQLQAATREARASMGPVQQGTICMQ (in isoform 2)
Domain & Motif Annotations
Protein Families (2)
- G-protein coupled receptor 1 family
- Opsin subfamily
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
Supporting Publications2
| PMID | Title | Abstract |
|---|---|---|
| 38698420 | Single-sEV profiling identifies the TACSTD2 + sEV subpopulation as a factor of tumor susceptibility in the elderly. | No abstract available |
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No abstract available |