Protein detail

OPN3

Opsin-3 (Encephalopsin) (Panopsin)

Entry name OPN3	UniProt ID Q9H1Y3	EVMP score 0.38
Frequency 2	Transmembrane count 7	Protein classification G-protein coupled receptorsPredicted membrane proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Opsin-3 (Encephalopsin) (Panopsin)

Protein Class

G-protein coupled receptorsPredicted membrane proteins

Protein Function

G-protein coupled receptors:Opsins
G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

41..65; Helical; Name=1; 78..102; Helical; Name=2; 118..137; Helical; Name=3; 154..177; Helical; Name=4; 202..229; Helical; Name=5; 256..279; Helical; Name=6; 288..312; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000054277

Entrez Gene Symbol

OPN3

Gene Synonym

ECPNencephalopsinERONMO-1PPP1R116

Gene Description

Opsin 3

Chromosome

Position

241590102-241677376

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue SpecificbrainBrain Regional SpecificcerebellumCell SpecificBrain excitatory neuronsSingle-Nuclei Brain Specificupper rhombic lip

Function & Pathway

Protein Function

G-protein coupled receptors:Opsins
G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component

Molecular Function

Biological Process

Reactome

Mediation Categories

Fusion and delivery mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

41 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane	transmembrane	GO_Intercell	No	No	No	Yes	No
transmembrane	transmembrane	LOCATE	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometryMass spectrometry [LTQ-FT Ultra]Western blotting	2	22490681 36973758

Sequence, Structure & Domains

Sequences

Length

402

Mass

44,873

Sequence

MYSGNRSGGHGYWDGGGAAGAEGPAPAGTLSPAPLFSPGTYERLALLLGSIGLLGVGNNLLVLVLYYKFQRLRTPTHLLLVNISLSDLLVSLFGVTFTFVSCLRNGWVWDTVGCVWDGFSGSLFGIVSIATLTVLAYERYIRVVHARVINFSWAWRAITYIWLYSLAWAGAPLLGWNRYILDVHGLGCTVDWKSKDANDSSFVLFLFLGCLVVPLGVIAHCYGHILYSIRMLRCVEDLQTIQVIKILKYEKKLAKMCFLMIFTFLVCWMPYIVICFLVVNGHGHLVTPTISIVSYLFAKSNTVYNPVIYVFMIRKFRRSLLQLLCLRLLRCQRPAKDLPAAGSEMQIRPIVMSQKDGDRPKKKVTFNSSSIIFIITSDESLSVDDSDKTNGSKVDVIQVRPL

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=1-4b-5-6; IsoId=Q9H1Y3-1; Sequence=Displayed; Name=2; Synonyms=1-2-5-6; IsoId=Q9H1Y3-2; Sequence=VSP_010209

Alternative Sequence

126..231; IVSIATLTVLAYERYIRVVHARVINFSWAWRAITYIWLYSLAWAGAPLLGWNRYILDVHGLGCTVDWKSKDANDSSFVLFLFLGCLVVPLGVIAHCYGHILYSIRM -> WISQLQAATREARASMGPVQQGTICMQ (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Protein Families

G-protein coupled receptor 1 family
Opsin subfamily

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.

Clinical Relevance

Antibody

CAB013682 HPA049243