Protein detail

OPN3

Opsin-3 (Encephalopsin) (Panopsin)

Entry name
OPN3
UniProt ID
Q9H1Y3
EVMP confidence score
0.40
Supporting publications (n)
2
Transmembrane count
7
Protein classification
G-protein coupled receptorsPredicted membrane proteins
Basic Information
Protein Names
Opsin-3 (Encephalopsin) (Panopsin)
Protein Class (2)
G-protein coupled receptorsPredicted membrane proteins
Protein Function (2)
  • G-protein coupled receptors:Opsins
  • G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
41..65; Helical; Name=1; 78..102; Helical; Name=2; 118..137; Helical; Name=3; 154..177; Helical; Name=4; 202..229; Helical; Name=5; 256..279; Helical; Name=6; 288..312; Helical; Name=7
Transmembrane Count
7
Ensembl
ENSG00000054277
Entrez Gene Symbol
OPN3
Gene Synonym (5)
ECPNencephalopsinERONMO-1PPP1R116
Gene Description
Opsin 3
Chromosome
1
Position
241590102-241677376
Supporting publications (n)
2
EVMP confidence score
0.40
Fluorescence & Localization
OPN3 fluorescence
Tissue SpecificbrainBrain Regional SpecificcerebellumCell SpecificBrain excitatory neuronsSingle-Nuclei Brain Specificupper rhombic lip
Function & Pathway
Protein Function (2)
  • G-protein coupled receptors:Opsins
  • G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component (4)
Molecular Function (6)
Biological Process (3)
Reactome (5)
Mediation Categories (3)
Fusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence42

Ligand-Receptor Signaling (41)

41 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
transmembranetransmembrane_predictedPhobiusYes
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Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity CaptureMass spectrometryMass spectrometry [LTQ-FT Ultra]Western blotting22249068136973758
Sequence, Structure & Domains

Sequences

Length
402
Mass
44,873
Sequence
MYSGNRSGGHGYWDGGGAAGAEGPAPAGTLSPAPLFSPGTYERLALLLGSIGLLGVGNNLLVLVLYYKFQRLRTPTHLLLVNISLSDLLVSLFGVTFTFVSCLRNGWVWDTVGCVWDGFSGSLFGIVSIATLTVLAYERYIRVVHARVINFSWAWRAITYIWLYSLAWAGAPLLGWNRYILDVHGLGCTVDWKSKDANDSSFVLFLFLGCLVVPLGVIAHCYGHILYSIRMLRCVEDLQTIQVIKILKYEKKLAKMCFLMIFTFLVCWMPYIVICFLVVNGHGHLVTPTISIVSYLFAKSNTVYNPVIYVFMIRKFRRSLLQLLCLRLLRCQRPAKDLPAAGSEMQIRPIVMSQKDGDRPKKKVTFNSSSIIFIITSDESLSVDDSDKTNGSKVDVIQVRPL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=1-4b-5-6; IsoId=Q9H1Y3-1; Sequence=Displayed; Name=2; Synonyms=1-2-5-6; IsoId=Q9H1Y3-2; Sequence=VSP_010209
Alternative Sequence
126..231; IVSIATLTVLAYERYIRVVHARVINFSWAWRAITYIWLYSLAWAGAPLLGWNRYILDVHGLGCTVDWKSKDANDSSFVLFLFLGCLVVPLGVIAHCYGHILYSIRM -> WISQLQAATREARASMGPVQQGTICMQ (in isoform 2)

Domain & Motif Annotations

Protein Families (2)
  • G-protein coupled receptor 1 family
  • Opsin subfamily
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
Clinical Relevance
Antibody (2)
CAB013682HPA049243
Supporting Publications2
PMIDTitleRelated sentences
38698420Single-sEV profiling identifies the TACSTD2 + sEV subpopulation as a factor of tumor susceptibility in the elderly.No related sentences available
38731868The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.No related sentences available