Protein detail

OPN3

Opsin-3 (Encephalopsin) (Panopsin)

Entry name
OPN3
UniProt ID
Q9H1Y3
EVMP score
0.38
Frequency
2
Transmembrane count
7
Protein classification
G-protein coupled receptorsPredicted membrane proteins
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Opsin-3 (Encephalopsin) (Panopsin)
Protein Class
G-protein coupled receptorsPredicted membrane proteins
Protein Function
  • G-protein coupled receptors:Opsins
  • G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
41..65; Helical; Name=1; 78..102; Helical; Name=2; 118..137; Helical; Name=3; 154..177; Helical; Name=4; 202..229; Helical; Name=5; 256..279; Helical; Name=6; 288..312; Helical; Name=7
Transmembrane Count
7
Ensembl
ENSG00000054277
Entrez Gene Symbol
OPN3
Gene Synonym
ECPNencephalopsinERONMO-1PPP1R116
Gene Description
Opsin 3
Chromosome
1
Position
241590102-241677376
Frequency
2
EVMP Score
0.38
Fluorescence & Localization
OPN3 fluorescence
Tissue SpecificbrainBrain Regional SpecificcerebellumCell SpecificBrain excitatory neuronsSingle-Nuclei Brain Specificupper rhombic lip
Function & Pathway
Protein Function
  • G-protein coupled receptors:Opsins
  • G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Fusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

41 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
transmembranetransmembrane_predictedPhobiusNoNoNoYesNo
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Regulatory Interaction Network

0 records.

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity CaptureMass spectrometryMass spectrometry [LTQ-FT Ultra]Western blotting22249068136973758
Sequence, Structure & Domains

Sequences

Length
402
Mass
44,873
Sequence
MYSGNRSGGHGYWDGGGAAGAEGPAPAGTLSPAPLFSPGTYERLALLLGSIGLLGVGNNLLVLVLYYKFQRLRTPTHLLLVNISLSDLLVSLFGVTFTFVSCLRNGWVWDTVGCVWDGFSGSLFGIVSIATLTVLAYERYIRVVHARVINFSWAWRAITYIWLYSLAWAGAPLLGWNRYILDVHGLGCTVDWKSKDANDSSFVLFLFLGCLVVPLGVIAHCYGHILYSIRMLRCVEDLQTIQVIKILKYEKKLAKMCFLMIFTFLVCWMPYIVICFLVVNGHGHLVTPTISIVSYLFAKSNTVYNPVIYVFMIRKFRRSLLQLLCLRLLRCQRPAKDLPAAGSEMQIRPIVMSQKDGDRPKKKVTFNSSSIIFIITSDESLSVDDSDKTNGSKVDVIQVRPL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=1-4b-5-6; IsoId=Q9H1Y3-1; Sequence=Displayed; Name=2; Synonyms=1-2-5-6; IsoId=Q9H1Y3-2; Sequence=VSP_010209
Alternative Sequence
126..231; IVSIATLTVLAYERYIRVVHARVINFSWAWRAITYIWLYSLAWAGAPLLGWNRYILDVHGLGCTVDWKSKDANDSSFVLFLFLGCLVVPLGVIAHCYGHILYSIRM -> WISQLQAATREARASMGPVQQGTICMQ (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Protein Families
  • G-protein coupled receptor 1 family
  • Opsin subfamily
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
Clinical Relevance
Antibody
CAB013682HPA049243