Protein detail
S1PR5
Sphingosine 1-phosphate receptor 5 (S1P receptor 5) (S1P5) (Endothelial differentiation G-protein-coupled receptor 8) (Sphingosine 1-phosphate receptor Edg-8) (S1P receptor Edg-8)
Protein symbol S1PR5 | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 7 | Protein classification FDA approved drug targetsG-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteins |
Basic Information
Protein Names
Sphingosine 1-phosphate receptor 5 (S1P receptor 5) (S1P5) (Endothelial differentiation G-protein-coupled receptor 8) (Sphingosine 1-phosphate receptor Edg-8) (S1P receptor Edg-8)
Protein Class
FDA approved drug targetsG-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- G-protein coupled receptors:Lysolipids receptors
- FDA approved drug targets:Small molecule drugs
- Predicted intracellular proteins
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
41..61; Helical; Name=1; 71..91; Helical; Name=2; 112..132; Helical; Name=3; 152..172; Helical; Name=4; 193..213; Helical; Name=5; 253..273; Helical; Name=6; 288..308; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym
Edg-8EDG8
Gene Description
Sphingosine-1-phosphate receptor 5
Chromosome
19
Position
10512742-10517931
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Cell SpecificDecidual stromal cellsSingle-Nuclei Brain Specificendothelial cellBlood Cell Specificclassical monocyte
Function & Pathway
Protein Function
- G-protein coupled receptors:Lysolipids receptors
- FDA approved drug targets:Small molecule drugs
- Predicted intracellular proteins
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Clinical-translation mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
45 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | HPMR | No | Yes | No | Yes | No |
| receptor | receptor | CellTalkDB | No | Yes | No | Yes | No |
| receptor | receptor | Surfaceome | No | Yes | No | Yes | No |
| gpcr | receptor | DGIdb | No | Yes | No | Yes | No |
| gpcr | receptor | Almen2009 | No | Yes | No | Yes | No |
| rhodopsin | receptor | Almen2009 | No | Yes | No | Yes | No |
| gpcr | receptor | UniProt_keyword | No | Yes | No | Yes | No |
| seven_transmembrane_7tm | receptor | HPMR | No | Yes | No | Yes | No |
| 7tm_a | receptor | HPMR | No | Yes | No | Yes | No |
| lysosphingolipid_lysophosphatidic_acid_edg_7tm_a | receptor | HPMR | No | Yes | No | Yes | No |
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Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| S1PR5 | Q9H228 | GNAI3 | P08754 | Yes | Yes | No | WangSIGNOR | SIGNOR:31160049 |
| S1PR5 | Q9H228 | GNAI1 | P63096 | Yes | Yes | No | SIGNORHPRDHINTWangSPIKE_LC | SPIKE_LC:16189514HINT:34526663HPRD:11069896SIGNOR:31160049 |
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
398
Mass
41,775
Sequence
MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALTASVLSLLAIALERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRARRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSLLNPIIYTLTNRDLRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGGLRRCLPPGLDGSFSGSERSSPQRDGLDTSGSTGSPGAPTAARTLVSEPAAD
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9H228-1; Sequence=Displayed; Name=2; IsoId=Q9H228-2; Sequence=VSP_013369, VSP_013370
Alternative Sequence
214..310; RIYCQVRANARRLPARPGTAGTTSTRARRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSLLNPIIYTLTN -> LAGLAAHAQRGAPGLCGMLGPPHPAAVARRGVPGAHLSCTPAGRSLPGTGHGQLTSEPHHLHAHQPRPAPRAPAPGLLRTPLLRQRPEWLPAVGERG (in isoform 2); 311..398; Missing (in isoform 2)
3D Structural Models
Turn
26..28
Helix
13..21; 38..63; 65..67; 70..94; 97..102; 105..133; 148..171; 179..181; 191..223; 243..246; 250..276; 283..286; 289..309; 311..321
Beta Strand
141..143; 174..177; 184..186
3D Structure
Electron microscopy (1); X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
333..347; Low complexity
Region
329..398; Disordered
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance
Disease Involvement
FDA approved drug targets
Related Diseases
Biomarker
Phase 1
Drug Targets
FDA approved drug targets
Antibody