Protein detail

S1PR5

Sphingosine 1-phosphate receptor 5 (S1P receptor 5) (S1P5) (Endothelial differentiation G-protein-coupled receptor 8) (Sphingosine 1-phosphate receptor Edg-8) (S1P receptor Edg-8)

Entry name S1PR5	UniProt ID Q9H228	EVMP confidence score 0.40
Supporting publications (n) 1	Transmembrane count 7	Protein classification FDA approved drug targetsG-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteins

Basic Information

Protein Names

Sphingosine 1-phosphate receptor 5 (S1P receptor 5) (S1P5) (Endothelial differentiation G-protein-coupled receptor 8) (Sphingosine 1-phosphate receptor Edg-8) (S1P receptor Edg-8)

Protein Class (4)

FDA approved drug targetsG-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteins

Protein Function (4)

G-protein coupled receptors:Lysolipids receptors
FDA approved drug targets:Small molecule drugs
Predicted intracellular proteins
G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

41..61; Helical; Name=1; 71..91; Helical; Name=2; 112..132; Helical; Name=3; 152..172; Helical; Name=4; 193..213; Helical; Name=5; 253..273; Helical; Name=6; 288..308; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000180739

Entrez Gene Symbol

S1PR5

Gene Synonym (2)

Edg-8EDG8

Gene Description

Sphingosine-1-phosphate receptor 5

Chromosome

Position

10512742-10517931

Supporting publications (n)

EVMP confidence score

0.40

Fluorescence & Localization

Cell SpecificDecidual stromal cellsSingle-Nuclei Brain Specificendothelial cellBlood Cell Specificclassical monocyte

Function & Pathway

Protein Function (4)

G-protein coupled receptors:Lysolipids receptors
FDA approved drug targets:Small molecule drugs
Predicted intracellular proteins
G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component (3)

Molecular Function (3)

Biological Process (3)

KEGG (2)

Reactome (5)

Mediation Categories (2)

Clinical-translation mediationReceptor-signaling mediation

Relations & Evidence49

Ligand-Receptor Signaling (45)

45 records.

Category	Parent	Database	Receiver	Plasma Membrane (Transmembrane)
receptor	receptor	EMBRACE	Yes	Yes
gpcr	receptor	GPCRdb	Yes	Yes
sphingosine_phosphate	receptor	HGNC	Yes	Yes
receptor	receptor	HGNC	Yes	Yes
transmembrane	transmembrane_predicted	Phobius		Yes

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Regulatory Interaction Network (2)

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
S1PR5	Q9H228	GNAI3	P08754	Yes	Yes		WangSIGNOR	SIGNOR:31160049
S1PR5	Q9H228	GNAI1	P63096	Yes	Yes		SIGNORHPRDHINTWangSPIKE_LC	SPIKE_LC:16189514 HINT:34526663 HPRD:11069896 SIGNOR:31160049

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	S1PR5	Q9H228	2	PDB	PDB:7yxa

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	7	37205098 39940641 40748658 27894104 40089067 29148239 32089743

Sequence, Structure & Domains

Sequences

Length

398

Mass

41,775

Sequence

MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALTASVLSLLAIALERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRARRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSLLNPIIYTLTNRDLRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGGLRRCLPPGLDGSFSGSERSSPQRDGLDTSGSTGSPGAPTAARTLVSEPAAD

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9H228-1; Sequence=Displayed; Name=2; IsoId=Q9H228-2; Sequence=VSP_013369, VSP_013370

Alternative Sequence

214..310; RIYCQVRANARRLPARPGTAGTTSTRARRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSLLNPIIYTLTN -> LAGLAAHAQRGAPGLCGMLGPPHPAAVARRGVPGAHLSCTPAGRSLPGTGHGQLTSEPHHLHAHQPRPAPRAPAPGLLRTPLLRQRPEWLPAVGERG (in isoform 2); 311..398; Missing (in isoform 2)

3D Structural Models

Turn

26..28

Helix

13..21; 38..63; 65..67; 70..94; 97..102; 105..133; 148..171; 179..181; 191..223; 243..246; 250..276; 283..286; 289..309; 311..321

Beta Strand

141..143; 174..177; 184..186

3D Structure

Electron microscopy (1); X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

333..347; Low complexity

Region

329..398; Disordered

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance

Disease Involvement

FDA approved drug targets

Related Diseases

Multiple sclerosis

Biomarker

Phase 1

Drug Targets

FDA approved drug targets

Drugs (4)

FINGOLIMOD LAURYL SULFATE ASP-4058 AMISELIMOD HYDROCHLORIDE FINGOLIMOD HYDROCHLORIDE

Antibody

HPA029683

Supporting Publications1

PMID	Title	Related sentences
31753726	Serum extracellular vesicles contain SPARC and LRG1 as biomarkers of colon cancer and differ by tumour primary location.	No related sentences available