Protein detail
MMP28
Matrix metalloproteinase-28 (MMP-28) (EC 3.4.24.-) (Epilysin)
Protein symbol MMP28 | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count | Protein classification EnzymesPredicted secreted proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Matrix metalloproteinase-28 (MMP-28) (EC 3.4.24.-) (Epilysin)
Protein Class
EnzymesPredicted secreted proteins
Protein Function
- Peptidases:Metallopeptidases
- Enzymes
- Predicted secreted proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
MMP20MMPL1MT6-MMP
Gene Description
Matrix metallopeptidase 25
Chromosome
16
Position
3046062-3060726
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecifickidneyCell SpecificAstrocytesSingle-Nuclei Brain Specificastrocyte
Function & Pathway
Protein Function
- Peptidases:Metallopeptidases
- Enzymes
- Predicted secreted proteins
Cellular Component
Molecular Function
KEGG
- hsa04928 Parathyroid hormone synthesis
- secretion and action
Reactome
Mediation Categories
Fusion and delivery mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
26 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm_regulator | ecm_regulator | OmniPath | Yes | No | Yes | No | No |
| m10_metallopeptidase | cell_surface_peptidase | OmniPath | Yes | No | Yes | No | No |
| cell_surface_enzyme | cell_surface_enzyme | OmniPath | Yes | No | Yes | No | No |
| cell_surface_peptidase | cell_surface_peptidase | OmniPath | Yes | No | Yes | No | No |
| secreted_peptidase | secreted_peptidase | OmniPath | No | No | Yes | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | Yes | No | No |
| transmembrane | transmembrane | OmniPath | No | No | Yes | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | Yes | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | Yes | No | No |
| secreted | secreted | UniProt_keyword | No | No | Yes | No | No |
Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| MMP25 | Q9NPA2 | MMP2 | P08253 | Yes | Yes | No | HPRDSIGNOR | HPRD:14583471HPRD:8663332SIGNOR:14583471 |
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
520
Mass
58,939
Sequence
MVARVGLLLRALQLLLWGHLDAQPAERGGQELRKEAEAFLEKYGYLNEQVPKAPTSTRFSDAIRAFQWVSQLPVSGVLDRATLRQMTRPRCGVTDTNSYAAWAERISDLFARHRTKMRRKKRFAKQGNKWYKQHLSYRLVNWPEHLPEPAVRGAVRAAFQLWSNVSALEFWEAPATGPADIRLTFFQGDHNDGLGNAFDGPGGALAHAFLPRRGEAHFDQDERWSLSRRRGRNLFVVLAHEIGHTLGLTHSPAPRALMAPYYKRLGRDALLSWDDVLAVQSLYGKPLGGSVAVQLPGKLFTDFETWDSYSPQGRRPETQGPKYCHSSFDAITVDRQQQLYIFKGSHFWEVAADGNVSEPRPLQERWVGLPPNIEAAAVSLNDGDFYFFKGGRCWRFRGPKPVWGLPQLCRAGGLPRHPDAALFFPPLRRLILFKGARYYVLARGGLQVEPYYPRSLQDWGGIPEEVSGALPRPDGSIIFFRDDRYWRLDQAKLQATTSGRWATELPWMGCWHANSGSALF
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9H239-1; Sequence=Displayed; Name=2; IsoId=Q9H239-2; Sequence=VSP_040552, VSP_040553
Alternative Sequence
128..130; NKW -> EHC (in isoform 2); 131..520; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Repeat
325..369; Hemopexin 1; 370..409; Hemopexin 2; 415..463; Hemopexin 3; 464..510; Hemopexin 4
Motif
89..96; Cysteine switch
Domain (CC)
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Protein Families
Peptidase M10A family
Sequence Similarities
Belongs to the peptidase M10A family.