Protein detail

MMP28

Matrix metalloproteinase-28 (MMP-28) (EC 3.4.24.-) (Epilysin)

Entry name MMP28	UniProt ID Q9H239	EVMP confidence score 0.40
Supporting publications (n) 2	Transmembrane count	Protein classification EnzymesPredicted secreted proteins

Basic Information

Protein Names

Matrix metalloproteinase-28 (MMP-28) (EC 3.4.24.-) (Epilysin)

Protein Class (2)

EnzymesPredicted secreted proteins

Protein Function (3)

Peptidases:Metallopeptidases
Enzymes
Predicted secreted proteins

Ensembl

ENSG00000008516

Entrez Gene Symbol

MMP25

Gene Synonym (3)

MMP20MMPL1MT6-MMP

Gene Description

Matrix metallopeptidase 25

Chromosome

Position

3046062-3060726

Supporting publications (n)

EVMP confidence score

0.40

Fluorescence & Localization

Tissue SpecifickidneyCell SpecificAstrocytesSingle-Nuclei Brain Specificastrocyte

Function & Pathway

Protein Function (3)

Peptidases:Metallopeptidases
Enzymes
Predicted secreted proteins

Cellular Component (6)

Molecular Function (3)

KEGG (2)

hsa04928 Parathyroid hormone synthesis
secretion and action

Reactome (5)

Mediation Categories (2)

Fusion and delivery mediationImmune mediation

Relations & Evidence28

Ligand-Receptor Signaling (26)

26 records.

Category	Parent	Database	Transmitter	Secreted
ecm_regulator	ecm_regulator	OmniPath	Yes	Yes
m10_metallopeptidase	cell_surface_peptidase	OmniPath	Yes	Yes
cell_surface_enzyme	cell_surface_enzyme	OmniPath	Yes	Yes
cell_surface_peptidase	cell_surface_peptidase	OmniPath	Yes	Yes
secreted_peptidase	secreted_peptidase	OmniPath		Yes
transmembrane	transmembrane	Ramilowski_location		Yes
transmembrane	transmembrane	OmniPath		Yes
plasma_membrane	plasma_membrane	UniProt_location		Yes
plasma_membrane	plasma_membrane	OmniPath		Yes
secreted	secreted	UniProt_keyword		Yes

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Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
MMP25	Q9NPA2	MMP2	P08253	Yes	Yes		HPRDSIGNOR	HPRD:14583471 HPRD:8663332 SIGNOR:14583471

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	3	35119778 27821849 38716512

Sequence, Structure & Domains

Sequences

Length

520

Mass

58,939

Sequence

MVARVGLLLRALQLLLWGHLDAQPAERGGQELRKEAEAFLEKYGYLNEQVPKAPTSTRFSDAIRAFQWVSQLPVSGVLDRATLRQMTRPRCGVTDTNSYAAWAERISDLFARHRTKMRRKKRFAKQGNKWYKQHLSYRLVNWPEHLPEPAVRGAVRAAFQLWSNVSALEFWEAPATGPADIRLTFFQGDHNDGLGNAFDGPGGALAHAFLPRRGEAHFDQDERWSLSRRRGRNLFVVLAHEIGHTLGLTHSPAPRALMAPYYKRLGRDALLSWDDVLAVQSLYGKPLGGSVAVQLPGKLFTDFETWDSYSPQGRRPETQGPKYCHSSFDAITVDRQQQLYIFKGSHFWEVAADGNVSEPRPLQERWVGLPPNIEAAAVSLNDGDFYFFKGGRCWRFRGPKPVWGLPQLCRAGGLPRHPDAALFFPPLRRLILFKGARYYVLARGGLQVEPYYPRSLQDWGGIPEEVSGALPRPDGSIIFFRDDRYWRLDQAKLQATTSGRWATELPWMGCWHANSGSALF

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9H239-1; Sequence=Displayed; Name=2; IsoId=Q9H239-2; Sequence=VSP_040552, VSP_040553

Alternative Sequence

128..130; NKW -> EHC (in isoform 2); 131..520; Missing (in isoform 2)

Domain & Motif Annotations

Repeat

325..369; Hemopexin 1; 370..409; Hemopexin 2; 415..463; Hemopexin 3; 464..510; Hemopexin 4

Motif

89..96; Cysteine switch

Domain (CC)

The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

Protein Families

Peptidase M10A family

Sequence Similarities

Belongs to the peptidase M10A family.

Clinical Relevance

Antibody (2)

CAB025177 HPA055640

Supporting Publications2

PMID	Title	Related sentences
38113368	In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.	No related sentences available
41068253	Identification of plasma extracellular vesicle protein biomarkers in diabetic retinopathy progression.	No related sentences available