Protein detail
CAD23
Cadherin-23 (Otocadherin)
Protein symbol CAD23 | UniProt ID | EVMP score 0.38 |
Frequency | Transmembrane count 1 | Protein classification Disease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins |
Basic Information
Protein Names
Cadherin-23 (Otocadherin)
Protein Class
Disease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Predicted intracellular proteins
- Human disease related genes:Endocrine and metabolic diseases:Hypothalamus and pituitary gland diseases
- Human disease related genes:Endocrine and metabolic diseases:Adrenal gland diseases
- Disease related genes
- Human disease related genes:Nervous system diseases:Eye disease
- Human disease related genes:Nervous system diseases:Ear disease
Transmembrane
3065..3085; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CDHR23DFNB12USH1D
Gene Description
Cadherin related 23
Chromosome
10
Position
71396920-71815947
EVMP Score
0.38
Fluorescence & Localization
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Human disease related genes:Endocrine and metabolic diseases:Hypothalamus and pituitary gland diseases
- Human disease related genes:Endocrine and metabolic diseases:Adrenal gland diseases
- Disease related genes
- Human disease related genes:Nervous system diseases:Eye disease
- Human disease related genes:Nervous system diseases:Ear disease
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
25 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | LOCATE | No | No | No | Yes | No |
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| cadherin_related | cell_adhesion | HGNC | Yes | Yes | No | Yes | No |
| adhesion | adhesion | HGNC | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | Zhong2015 | Yes | Yes | No | Yes | No |
| icam | cell_adhesion | Zhong2015 | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | HGNC | Yes | Yes | No | Yes | No |
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Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| CAD23 | Q9H251 | CTNB1 | P35222 | Yes | Yes | No | SIGNOR | SIGNOR:21255999 |
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 34889606 |
Sequence, Structure & Domains
Sequences
Length
3,354
Mass
369,494
Sequence
MGRHVATSCHVAWLLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPDGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTFDLFMAYSPGYFVVDIVARDLAGHNDTAIIGIYILRDDQRVKIVINEIPDRVRGFEEEFIHLLSNITGAIVNTDNVQFHVDKKGRVNFAQTELLIHVVNRDTNRILDVDRVIQMIDENKEQLRNLFRNYNVLDVQPAISVRLPDDMSALQMAIIVLAILLFLAAMLFVLMNWYYRTVHKRKLKAIVAGSAGNRGFIDIMDMPNTNKYSFDGANPVWLDPFCRNLELAAQAEHEDDLPENLSEIADLWNSPTRTHGTFGREPAAVKPDDDRYLRAAIQEYDNIAKLGQIIREGPIKGSLLKVVLEDYLRLKKLFAQRMVQKASSCHSSISELIQTELDEEPGDHSPGQGSLRFRHKPPVELKGPDGIHVVHGSTGTLLATDLNSLPEEDQKGLGRSLETLTAAEATAFERNARTESAKSTPLHKLRDVIMETPLEITEL
Alternative Products
Event=Alternative splicing; Named isoforms=11; Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q9H251-1; Sequence=Displayed; Name=2; IsoId=Q9H251-2; Sequence=VSP_000645; Name=3; IsoId=Q9H251-3; Sequence=VSP_000646; Name=4; IsoId=Q9H251-4; Sequence=VSP_000647; Name=5; IsoId=Q9H251-5; Sequence=VSP_013268, VSP_013269; Name=6; IsoId=Q9H251-6; Sequence=VSP_035289, VSP_035290; Name=7; Synonyms=B1; IsoId=Q9H251-7; Sequence=VSP_044260; Name=8; IsoId=Q9H251-8; Sequence=VSP_044261, VSP_000645; Name=9; Synonyms=B2; IsoId=Q9H251-9; Sequence=VSP_044260, VSP_000647; Name=10; Synonyms=C1; IsoId=Q9H251-10; Sequence=VSP_047923, VSP_047924; Name=11; Synonyms=C2; IsoId=Q9H251-11; Sequence=VSP_047923, VSP_047924, VSP_000647
Alternative Sequence
1..2240; Missing (in isoform 7 and isoform 9); 1..24; MGRHVATSCHVAWLLVLISGCWGQ -> MRSWFQQDPMVGACTTGTRASHPK (in isoform 10 and isoform 11); 25..3127; Missing (in isoform 10 and isoform 11); 143; E -> EVGATG (in isoform 8); 379..380; Missing (in isoform 2 and isoform 8); 484..530; ATDNDAGTFGEVSYFFSDDPDRFSLDKDTGLIMLIARLDYELIQRFT -> VSPRFTAGPLSSPGPTVVRHPEGFCPRDLSNQGRRHPQIPELCLLVY (in isoform 5); 531..3354; Missing (in isoform 5); 1124..1212; LKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQ -> EEDLASPCISPAPPRRAFQSSGEKETSQFPGKELRREPGPSKAQNRAAFTEPLAEAPLLGSKQAQEERAPLPREQAQQLQGSEGEKGGP (in isoform 6); 1213..3354; Missing (in isoform 6); 1403; Missing (in isoform 3); 3212..3246; Missing (in isoform 4, isoform 9 and isoform 11)
3D Structural Models
Turn
702..704; 723..725; 736..738; 828..830; 1366..1368; 1379..1381; 1473..1475; 1487..1489
Helix
607..609; 629..631; 633..635; 706..708; 754..756; 808..811; 847..851; 1356..1361; 1449..1452; 1463..1465; 3187..3198; 3214..3226
Beta Strand
560..564; 566..571; 577..583; 597..605; 610..615; 618..623; 636..644; 652..662; 670..672; 674..683; 689..692; 710..715; 719..721; 727..732; 741..749; 759..769; 777..780; 782..787; 796..799; 813..819; 824..826; 832..835; 854..862; 874..880; 1312..1323; 1331..1334; 1347..1350; 1362..1364; 1370..1373; 1383..1392; 1394..1397; 1400..1409; 1425..1429; 1437..1444; 1454..1460; 1467..1472; 1476..1481; 1492..1501; 1503..1505; 1508..1518; 3351..3353
3D Structure
NMR spectroscopy (3); X-ray crystallography (3)
Domain & Motif Annotations
Domain (CC)
Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.; DOMAIN: Cadherin repeats 1 and 2 mediate calcium-dependent heterophilic interaction with PCDH15..
Domain (FT)
34..132; Cadherin 1; 133..236; Cadherin 2; 237..348; Cadherin 3; 349..460; Cadherin 4; 461..561; Cadherin 5; 562..671; Cadherin 6; 672..784; Cadherin 7; 779..890; Cadherin 8; 891..995; Cadherin 9; 996..1102; Cadherin 10; 1103..1208; Cadherin 11; 1210..1313; Cadherin 12; 1314..1418; Cadherin 13; 1420..1527; Cadherin 14; 1529..1634; Cadherin 15; 1635..1744; Cadherin 16; 1745..1851; Cadherin 17; 1852..1959; Cadherin 18; 1960..2069; Cadherin 19; 2070..2174; Cadherin 20; 2175..2293; Cadherin 21; 2297..2402; Cadherin 22; 2403..2509; Cadherin 23; 2510..2611; Cadherin 24; 2614..2722; Cadherin 25; 2729..2846; Cadherin 26; 2847..2975; Cadherin 27
Clinical Relevance
Disease Involvement
DeafnessDisease variantNon-syndromic deafnessRetinitis pigmentosaUsher syndrome
Antibody