Protein detail
KCNN2
Small conductance calcium-activated potassium channel protein 2 (SK2) (SKCa 2) (SKCa2) (KCa2.2)
Entry name KCNN2 | UniProt ID | EVMP confidence score 0.63 |
Supporting publications (n) 6 | Transmembrane count 6 | Protein classification Disease related genesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted membrane proteinsTransportersVoltage-gated ion channels |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Small conductance calcium-activated potassium channel protein 2 (SK2) (SKCa 2) (SKCa2) (KCa2.2)
Protein Class (7)
Disease related genesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted membrane proteinsTransportersVoltage-gated ion channels
Protein Function (5)
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Voltage-gated ion channels:Calcium-Activated Potassium Channels
- Transporters:Transporter channels and pores
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Transmembrane
138..158; Helical; Name=Segment S1; 168..188; Helical; Name=Segment S2; 214..234; Helical; Name=Segment S3; 256..276; Helical; Name=Segment S4; 305..325; Helical; Name=Segment S5; 374..394; Helical; Name=Segment S6
Transmembrane Count
6
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
hSK2KCa2.2
Gene Description
Potassium calcium-activated channel subfamily N member 2
Chromosome
5
Position
114055926-114496500
Supporting publications (n)
6
EVMP confidence score
0.63
Fluorescence & Localization2
Cell SpecificLate primary spermatocytes
Function & Pathway8
Protein Function (5)
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Voltage-gated ion channels:Calcium-Activated Potassium Channels
- Transporters:Transporter channels and pores
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Cellular Component (6)
Molecular Function (8)
- GO:0005242 inward rectifier potassium channel activity
- GO:0005515 protein binding
- GO:0005516 calmodulin binding
- GO:0015269 calcium-activated potassium channel activity
- GO:0016286 small conductance calcium-activated potassium channel activity
- GO:0019904 protein domain specific binding
- GO:0042803 protein homodimerization activity
- GO:0051393 alpha-actinin binding
Biological Process (3)
KEGG (4)
Reactome (7)
- R-hsa-9667769 acetylcholine inhibits contraction of outer hair cells
- R-hsa-1296052 ca2 activated k channels
- R-hsa-112316 neuronal system
- R-hsa-1296071 potassium channels
- R-hsa-9709957 sensory perception
- R-hsa-9659379 sensory processing of sound
- R-hsa-9662361 sensory processing of sound by outer hair cells of the cochlea
Canonical Pathways (2)
- M88 Pid cd8 tcr pathway
- M34 Pid tcr pathway
Mediation Categories (2)
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence31
Enzyme-Mediated Modification (5)
5 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| KCNN2 | PRKACA | P17612 | S | 464 | phosphorylation | PhosphoSite_MIMPMIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:16513649SIGNOR:16513649 |
| KCNN2 | PRKACA | P17612 | S | 567 | phosphorylation | PhosphoSite_MIMPMIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:16513649SIGNOR:16513649 |
| KCNN2 | PRKACA | P17612 | S | 568 | phosphorylation | PhosphoSite_MIMPMIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:16513649SIGNOR:16513649 |
| KCNN2 | PRKACA | P17612 | S | 569 | phosphorylation | PhosphoSite_MIMPMIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:16513649SIGNOR:16513649 |
| KCNN2 | PRKACA | P17612 | S | 135 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper |
Ligand-Receptor Signaling (22)
22 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| ion_channel | ion_channel | DGIdb | No | Yes | No | No | No |
| calcium_activated_potassium | ion_channel | HGNC | No | Yes | No | No | No |
| ion_channel | ion_channel | HGNC | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
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Regulatory Interaction Network (2)
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| UBE3A | Q05086 | KCNN2 | Q9H2S1 | Yes | Yes | No | SIGNOR | SIGNOR:26166566 |
| KAPCA | P17612 | KCNN2 | Q9H2S1 | Yes | No | Yes | PhosphoSite_MIMPMIMPPhosphoSite_norefSIGNORiPTMnetProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:16513649ProtMapper:16513649SIGNOR:16513649 |
Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 38716512 |
Sequence, Structure & Domains13
Sequences
Length
579
Mass
63,760
Sequence
MSSCRYNGGVMRPLSNLSASRRNLHEMDSEAQPLQPPASVGGGGGASSPSAAAAAAAAVSSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIEAQMESYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9H2S1-1; Sequence=Displayed; Name=2; IsoId=Q9H2S1-2; Sequence=VSP_044584
Alternative Sequence
1..348; Missing (in isoform 2)
3D Structural Models
Helix
410..412; 413..438; 445..484
Beta Strand
405..409; 439..442
3D Structure
X-ray crystallography (4)
Domain & Motif Annotations
Compositional Bias
90..103; Gly residues; 568..579; Low complexity
Domain (CC)
The coiled-coil domaim mediates heteromeic assembly.; DOMAIN: The calmodulin-binding domain (CaMBD) forms an elongated dimer with a calmodulin molecule bound at each end; each calmodulin wraps around three alpha-helices, two from one CaMBD subunit and one from the other.
Region
1..54; Disordered; 90..115; Disordered; 412..488; Calmodulin-binding; 551..579; Disordered
Protein Families (2)
- Potassium channel KCNN family
- KCa2.2/KCNN2 subfamily
Sequence Similarities
Belongs to the potassium channel KCNN family. KCa2.2/KCNN2 subfamily.
Clinical Relevance6
Disease Involvement (4)
Disease variantDystoniaFDA approved drug targetsIntellectual disability
Related Diseases (2)
Biomarker
Terminated; Clinical trial
Drug Targets
FDA approved drug targets
Drugs
Antibody
Supporting Publications6
| PMID | Title | Abstract |
|---|---|---|
| 32795414 | Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers. | Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers. |
| 37686366 | Identification of a Non-Invasive Urinary Exosomal Biomarker for Diabetic Nephropathy Using Data-Independent Acquisition Proteomics. | No abstract available |
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No abstract available |
| 39835386 | Comparison of nanoLC-MALDI-MS/MS with nanoLC-TIMS-MS/MS in the proteomic analysis of extracellular vesicles of bronchoalveolar lavage fluid. | No abstract available |
| 39873726 | Size-Dependent Separation of Extracellular Vesicle Subtypes with Exodisc Enabling Proteomic Analysis in Prostate Cancer. | No abstract available |
| 40784529 | Serum-derived exosome proteomics unveils the distinct and adjustable nature of the dampness constitution in traditional Chinese medicine. | No abstract available |