Protein detail
KCNN2
Small conductance calcium-activated potassium channel protein 2 (SK2) (SKCa 2) (SKCa2) (KCa2.2)
Protein symbol KCNN2 | UniProt ID | EVMP score 0.63 |
Frequency 6 | Transmembrane count 6 | Protein classification Disease related genesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted membrane proteinsTransportersVoltage-gated ion channels |
Basic Information
Protein Names
Small conductance calcium-activated potassium channel protein 2 (SK2) (SKCa 2) (SKCa2) (KCa2.2)
Protein Class
Disease related genesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted membrane proteinsTransportersVoltage-gated ion channels
Protein Function
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Voltage-gated ion channels:Calcium-Activated Potassium Channels
- Transporters:Transporter channels and pores
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Transmembrane
138..158; Helical; Name=Segment S1; 168..188; Helical; Name=Segment S2; 214..234; Helical; Name=Segment S3; 256..276; Helical; Name=Segment S4; 305..325; Helical; Name=Segment S5; 374..394; Helical; Name=Segment S6
Transmembrane Count
6
Ensembl
Entrez Gene Symbol
Gene Synonym
hSK2KCa2.2
Gene Description
Potassium calcium-activated channel subfamily N member 2
Chromosome
5
Position
114055926-114496500
Frequency
6
EVMP Score
0.63
Fluorescence & Localization
Cell SpecificLate primary spermatocytes
Function & Pathway
Protein Function
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Voltage-gated ion channels:Calcium-Activated Potassium Channels
- Transporters:Transporter channels and pores
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Cellular Component
Molecular Function
- GO:0005242 inward rectifier potassium channel activity
- GO:0005515 protein binding
- GO:0005516 calmodulin binding
- GO:0015269 calcium-activated potassium channel activity
- GO:0016286 small conductance calcium-activated potassium channel activity
- GO:0019904 protein domain specific binding
- GO:0042803 protein homodimerization activity
- GO:0051393 alpha-actinin binding
Biological Process
KEGG
Reactome
- R-hsa-9667769 acetylcholine inhibits contraction of outer hair cells
- R-hsa-1296052 ca2 activated k channels
- R-hsa-112316 neuronal system
- R-hsa-1296071 potassium channels
- R-hsa-9709957 sensory perception
- R-hsa-9659379 sensory processing of sound
- R-hsa-9662361 sensory processing of sound by outer hair cells of the cochlea
Canonical Pathways
- M88 Pid cd8 tcr pathway
- M34 Pid tcr pathway
Mediation Categories
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
5 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| KCNN2 | PRKACA | P17612 | S | 464 | phosphorylation | PhosphoSite_MIMPMIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:16513649SIGNOR:16513649 |
| KCNN2 | PRKACA | P17612 | S | 567 | phosphorylation | PhosphoSite_MIMPMIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:16513649SIGNOR:16513649 |
| KCNN2 | PRKACA | P17612 | S | 568 | phosphorylation | PhosphoSite_MIMPMIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:16513649SIGNOR:16513649 |
| KCNN2 | PRKACA | P17612 | S | 569 | phosphorylation | PhosphoSite_MIMPMIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:16513649SIGNOR:16513649 |
| KCNN2 | PRKACA | P17612 | S | 135 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper |
Ligand-Receptor Signaling
22 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | scConnect | No | Yes | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| UBE3A | Q05086 | KCNN2 | Q9H2S1 | Yes | Yes | No | SIGNOR | SIGNOR:26166566 |
| KAPCA | P17612 | KCNN2 | Q9H2S1 | Yes | No | Yes | PhosphoSite_MIMPMIMPPhosphoSite_norefSIGNORiPTMnetProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:16513649ProtMapper:16513649SIGNOR:16513649 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 38716512 |
Sequence, Structure & Domains
Sequences
Length
579
Mass
63,760
Sequence
MSSCRYNGGVMRPLSNLSASRRNLHEMDSEAQPLQPPASVGGGGGASSPSAAAAAAAAVSSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIEAQMESYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9H2S1-1; Sequence=Displayed; Name=2; IsoId=Q9H2S1-2; Sequence=VSP_044584
Alternative Sequence
1..348; Missing (in isoform 2)
3D Structural Models
Helix
410..412; 413..438; 445..484
Beta Strand
405..409; 439..442
3D Structure
X-ray crystallography (4)
Domain & Motif Annotations
Compositional Bias
90..103; Gly residues; 568..579; Low complexity
Domain (CC)
The coiled-coil domaim mediates heteromeic assembly.; DOMAIN: The calmodulin-binding domain (CaMBD) forms an elongated dimer with a calmodulin molecule bound at each end; each calmodulin wraps around three alpha-helices, two from one CaMBD subunit and one from the other.
Region
1..54; Disordered; 90..115; Disordered; 412..488; Calmodulin-binding; 551..579; Disordered
Protein Families
- Potassium channel KCNN family
- KCa2.2/KCNN2 subfamily
Sequence Similarities
Belongs to the potassium channel KCNN family. KCa2.2/KCNN2 subfamily.
Clinical Relevance
Disease Involvement
Disease variantDystoniaFDA approved drug targetsIntellectual disability
Related Diseases
Biomarker
Terminated; Clinical trial
Drug Targets
FDA approved drug targets
Drugs
Antibody