Protein detail

RNF39

RING finger protein 39 (EC 2.3.2.27) (Protein HZFw)

Entry name RNF39	UniProt ID Q9H2S5	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

RING finger protein 39 (EC 2.3.2.27) (Protein HZFw)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000204618

Entrez Gene Symbol

RNF39

Gene Synonym (3)

FAP216HZFw1LIRF

Gene Description

Ring finger protein 39

Chromosome

Position

30070266-30075849

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization2

Cell SpecificBreast lactating cells

Function & Pathway5

Protein Function

Predicted intracellular proteins

Cellular Component (2)

Molecular Function (3)

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence146

Ligand-Receptor Signaling (5)

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network (136)

136 records.

Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
COMPLEX:P62979_Q96B02	RNF39	Q9H2S5	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P0CG48_Q9NR09	RNF39	Q9H2S5	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P62979_Q96LR5	RNF39	Q9H2S5	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P0CG47_P49459	RNF39	Q9H2S5	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:O00762_P0CG48	RNF39	Q9H2S5	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P0CG47_Q969T4	RNF39	Q9H2S5	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P0CG47_Q5JXB2	RNF39	Q9H2S5	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P62979_Q16763	RNF39	Q9H2S5	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P0CG47_Q712K3	RNF39	Q9H2S5	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P0CG48_Q7Z7E8	RNF39	Q9H2S5	Yes	Yes	No	SIGNOR	SIGNOR:34199813

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Protein Complex Composition (4)

4 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
Ub:RING_E3	RNF39 UBB	P0CG47 Q9H2S5	0:0	SIGNOR	SIGNOR:SIGNOR-C519
Ub:RING_E3	RNF39 UBC	P0CG48 Q9H2S5	0:0	SIGNOR	SIGNOR:SIGNOR-C519
Ub:RING_E3	RNF39 RPS27A	P62979 Q9H2S5	0:0	SIGNOR	SIGNOR:SIGNOR-C519
Ub:RING_E3	RNF39 UBA52	P62987 Q9H2S5	0:0	SIGNOR	SIGNOR:SIGNOR-C519

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture	Western blottingFlow cytometry	3	41227296 40098346 40091455

Sequence, Structure & Domains7

Sequences

Length

420

Mass

45,525

Sequence

MWWRDLTRLRLWLKREAIPGEGRKAAKVNAGVGEKGIYTASSRGGPPSARSKAVTVVAEGAASRSWLSMDAPELGPGLVERLEQLATCPLCGGSFEDPVLLACEHSFCRACLARRWGTPPATGTEASPTACPCCGLPCPRRSLRSNVRLAVEVRISRELREKLAEPGARAGRRRGGRIPTMGCLDLPGEDMRKTWRRFEVPTSKSSNSEDDLPEDYPVVKKMLHRLTADLTLDPGTAHRRLLISADRRSVQLAPPGTPAPPDGPKRFDQLPAVLGAQGFGAGRHCWEVETADAASCRDSSGEDADDEESHYAVGAAGESVQRKGCVRLCPAGAVWAVEGRGGRLWALTAPEPTLLGGVEPPPRRIRVDLDWERGRVAFYDGRSLDLLYAFQAPGPLGERIFPLFCTCDPRAPLRIVPAES

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=HZFW1; IsoId=Q9H2S5-1; Sequence=Displayed; Name=2; Synonyms=HZFW2; IsoId=Q9H2S5-2; Sequence=VSP_014242; Name=3; Synonyms=HZFW3; IsoId=Q9H2S5-3; Sequence=VSP_014240, VSP_014241

Alternative Sequence

160..251; REKLAEPGARAGRRRGGRIPTMGCLDLPGEDMRKTWRRFEVPTSKSSNSEDDLPEDYPVVKKMLHRLTADLTLDPGTAHRRLLISADRRSVQ -> LFGGGIPHSFLGTHSHAHCRSINSNPHFRPKIMRPHLVSTFPRPCSKPNPFLPSGSQNLLSPTATTVLPDFSHSNHSRPAMGNRPSPSVLVK (in isoform 3); 252..420; Missing (in isoform 3); 326..391; Missing (in isoform 2)

Domain & Motif Annotations

Zinc Finger

88..135; RING-type

Domain (FT)

210..420; B30.2/SPRY

Clinical Relevance1

Antibody (2)

CAB019278 HPA047115

Supporting Publications1

PMID	Title	Abstract
30646616	Preferential Localization of MUC1 Glycoprotein in Exosomes Secreted by Non-Small Cell Lung Carcinoma Cells.	THBS1, ANXA6, HIST1H4A, COL18A1, MDK, SRGN, ENO1, TUBA4A, SLC3A2, GPI, MIF, MUC1, TALDO1, SLC7A5, ICAM1, HSP90AA1, G6PD, and LRP1 were found to be expressed in exosomes at more than 5-fold higher level as compared to total cellular membrane proteins.