Protein detail
RNF39
RING finger protein 39 (EC 2.3.2.27) (Protein HZFw)
Protein symbol RNF39 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
RING finger protein 39 (EC 2.3.2.27) (Protein HZFw)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
FAP216HZFw1LIRF
Gene Description
Ring finger protein 39
Chromosome
6
Position
30070266-30075849
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificBreast lactating cells
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Other mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
136 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| COMPLEX:P62987_Q7Z7E8 | RNF39 | Q9H2S5 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P0CG48_P61081 | RNF39 | Q9H2S5 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P62979_Q9Y385 | RNF39 | Q9H2S5 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P0CG48_P51965 | RNF39 | Q9H2S5 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P62987_Q96LR5 | RNF39 | Q9H2S5 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P0CG48_Q8WVN8 | RNF39 | Q9H2S5 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P51668_P62979 | RNF39 | Q9H2S5 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P60604_P62987 | RNF39 | Q9H2S5 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P0CG48_P61086 | RNF39 | Q9H2S5 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P62987_Q5JXB2 | RNF39 | Q9H2S5 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 |
Protein Complex Composition
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| Ub:RING_E3 | RNF39UBB | P0CG47Q9H2S5 | 0:0 | SIGNOR | SIGNOR:SIGNOR-C519 | |
| Ub:RING_E3 | RNF39UBC | P0CG48Q9H2S5 | 0:0 | SIGNOR | SIGNOR:SIGNOR-C519 | |
| Ub:RING_E3 | RNF39RPS27A | P62979Q9H2S5 | 0:0 | SIGNOR | SIGNOR:SIGNOR-C519 | |
| Ub:RING_E3 | RNF39UBA52 | P62987Q9H2S5 | 0:0 | SIGNOR | SIGNOR:SIGNOR-C519 |
Sequence, Structure & Domains
Sequences
Length
420
Mass
45,525
Sequence
MWWRDLTRLRLWLKREAIPGEGRKAAKVNAGVGEKGIYTASSRGGPPSARSKAVTVVAEGAASRSWLSMDAPELGPGLVERLEQLATCPLCGGSFEDPVLLACEHSFCRACLARRWGTPPATGTEASPTACPCCGLPCPRRSLRSNVRLAVEVRISRELREKLAEPGARAGRRRGGRIPTMGCLDLPGEDMRKTWRRFEVPTSKSSNSEDDLPEDYPVVKKMLHRLTADLTLDPGTAHRRLLISADRRSVQLAPPGTPAPPDGPKRFDQLPAVLGAQGFGAGRHCWEVETADAASCRDSSGEDADDEESHYAVGAAGESVQRKGCVRLCPAGAVWAVEGRGGRLWALTAPEPTLLGGVEPPPRRIRVDLDWERGRVAFYDGRSLDLLYAFQAPGPLGERIFPLFCTCDPRAPLRIVPAES
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=HZFW1; IsoId=Q9H2S5-1; Sequence=Displayed; Name=2; Synonyms=HZFW2; IsoId=Q9H2S5-2; Sequence=VSP_014242; Name=3; Synonyms=HZFW3; IsoId=Q9H2S5-3; Sequence=VSP_014240, VSP_014241
Alternative Sequence
160..251; REKLAEPGARAGRRRGGRIPTMGCLDLPGEDMRKTWRRFEVPTSKSSNSEDDLPEDYPVVKKMLHRLTADLTLDPGTAHRRLLISADRRSVQ -> LFGGGIPHSFLGTHSHAHCRSINSNPHFRPKIMRPHLVSTFPRPCSKPNPFLPSGSQNLLSPTATTVLPDFSHSNHSRPAMGNRPSPSVLVK (in isoform 3); 252..420; Missing (in isoform 3); 326..391; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Zinc Finger
88..135; RING-type
Domain (FT)
210..420; B30.2/SPRY