Protein detail
SO5A1
Solute carrier organic anion transporter family member 5A1 (Organic anion transporter polypeptide-related protein 4) (OATP-RP4) (OATPRP4) (Solute carrier family 21 member 15)
Entry name SO5A1 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 12 | Protein classification Predicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Solute carrier organic anion transporter family member 5A1 (Organic anion transporter polypeptide-related protein 4) (OATP-RP4) (OATPRP4) (Solute carrier family 21 member 15)
Protein Class
Predicted membrane proteinsTransporters
Protein Function
Transporters:Electrochemical Potential-driven transporters
Transmembrane
129..149; Helical; Name=1; 169..189; Helical; Name=2; 196..220; Helical; Name=3; 261..290; Helical; Name=4; 310..329; Helical; Name=5; 345..369; Helical; Name=6; 428..449; Helical; Name=7; 470..493; Helical; Name=8; 498..521; Helical; Name=9; 652..674; Helical; Name=10; 684..709; Helical; Name=11; 743..760; Helical; Name=12
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Gene Synonym
OATP-JOATP5A1OATPRP4SLC21A15
Gene Description
Solute carrier organic anion transporter family member 5A1
Chromosome
8
Position
69667046-69834978
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificBrain inhibitory neurons
Function & Pathway
Protein Function
Transporters:Electrochemical Potential-driven transporters
Cellular Component
Biological Process
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
18 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| transporter | transporter | Surfaceome | No | Yes | No | No | No |
| solute_carrier | transporter | Almen2009 | No | Yes | No | No | No |
| mfs | transporter | Surfaceome | No | Yes | No | No | No |
| slco | transporter | Surfaceome | No | Yes | No | No | No |
| slc | transporter | Surfaceome | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry；RNA Sequencing；Flow cytometry | 1 | 41307968 |
Sequence, Structure & Domains
Sequences
Length
848
Mass
91,864
Sequence
MDEGTGLQPGAGEQLEAPATAEAVQERCEPETLRSKSLPVLSSASCRPSLSPTSGDANPAFGCVDSSGHQELKQGPNPLAPSPSAPSTSAGLGDCNHRVDLSKTFSVSSALAMLQERRCLYVVLTDSRCFLVCMCFLTFIQALMVSGYLSSVITTIERRYSLKSSESGLLVSCFDIGNLVVVVFVSYFGGRGRRPLWLAVGGLLIAFGAALFALPHFISPPYQIQELNASAPNDGLCQGGNSTATLEPPACPKDSGGNNHWVYVALFICAQILIGMGSTPIYTLGPTYLDDNVKKENSSLYLAIMYVMGALGPAVGYLLGGLLIGFYVDPRNPVHLDQNDPRFIGNWWSGFLLCAIAMFLVIFPMFTFPKKLPPRHKKKKKKKFSVDAVSDDDVLKEKSNNSEQADKKVSSMGFGKDVRDLPRAAVRILSNMTFLFVSLSYTAESAIVTAFITFIPKFIESQFGIPASNASIYTGVIIVPSAGVGIVLGGYIIKKLKLGARESAKLAMICSGVSLLCFSTLFIVGCESINLGGINIPYTTGPSLTMPHRNLTGSCNVNCGCKIHEYEPVCGSDGITYFNPCLAGCVNSGNLSTGIRNYTECTCVQSRQVITPPTVGQRSQLRVVIVKTYLNENGYAVSGKCKRTCNTLIPFLVFLFIVTFITACAQPSAIIVTLRSVEDEERPFALGMQFVLLRTLAYIPTPIYFGAVIDTTCMLWQQECGVQGSCWEYNVTSFRFVYFGLAAGLKFVGFIFIFLAWYSIKYKEDGLQRRRQREFPLSTVSERVGHPDNARTRSCPAFSTQGEFHEETGLQKGIQCAAQTYPGPFPEAISSSADPGLEESPAALEPPS
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9H2Y9-1; Sequence=Displayed; Name=2; IsoId=Q9H2Y9-2; Sequence=VSP_045498; Name=3; IsoId=Q9H2Y9-3; Sequence=VSP_045499, VSP_045500
Alternative Sequence
420..474; Missing (in isoform 2); 675..687; RSVEDEERPFALG -> SIHSYSNLLWSSH (in isoform 3); 688..848; Missing (in isoform 3)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
24..34; Basic and acidic residues; 40..56; Polar residues
Domain (FT)
549..603; Kazal-like
Region
1..91; Disordered; 821..848; Disordered
Protein Families
Organo anion transporter (TC 2.A.60) family
Sequence Similarities
Belongs to the organo anion transporter (TC 2.A.60) family.
Clinical Relevance
Antibody