Protein detail
TTYH1
Protein tweety homolog 1 (hTTY1) (Volume-regulated anion channel subunit TTYH1)
Entry name TTYH1 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 5 | Protein classification Predicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Protein tweety homolog 1 (hTTY1) (Volume-regulated anion channel subunit TTYH1)
Protein Class
Predicted membrane proteinsTransporters
Protein Function
Transporters:Transporter channels and pores
Transmembrane
44..64; Helical; Name=1; 89..109; Helical; Name=2; 215..235; Helical; Name=3; 241..261; Helical; Name=4; 391..411; Helical; Name=5
Transmembrane Count
5
Ensembl
Entrez Gene Symbol
Gene Description
Tweety family member 1
Chromosome
19
Position
54415219-54436904
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificCorticotrophs
Function & Pathway
Protein Function
Transporters:Transporter channels and pores
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
29 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | No | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | No | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | No | No |
| transporter | transporter | Surfaceome | No | Yes | No | No | No |
| chloride_channels | transporter | Surfaceome | No | Yes | No | No | No |
| tweety | transporter | Surfaceome | No | Yes | No | No | No |
| channels | transporter | Surfaceome | No | Yes | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Western blotting | 1 | 39996590 |
Sequence, Structure & Domains
Sequences
Length
450
Mass
49,051
Sequence
MGAPPGYRPSAWVHLLHQLPRADFQLRPVPSVFAPQEQEYQQALLLVAALAGLGLGLSLIFIAVYLIRFCCCRPPEPPGSKIPSPGGGCVTWSCIVALLAGCTGIGIGFYGNSETSDGVSQLSSALLHANHTLSTIDHLVLETVERLGEAVRTELTTLEEVLEPRTELVAAARGARRQAEAAAQQLQGLAFWQGVPLSPLQVAENVSFVEEYRWLAYVLLLLLELLVCLFTLLGLAKQSKWLVIVMTVMSLLVLVLSWGSMGLEAATAVGLSDFCSNPDPYVLNLTQEETGLSSDILSYYLLCNRAVSNPFQQRLTLSQRALANIHSQLLGLEREAVPQFPSAQKPLLSLEETLNVTEGNFHQLVALLHCRSLHKDYGAALRGLCEDALEGLLFLLLFSLLSAGALATALCSLPRAWALFPPSDDYDDTDDDDPFNPQESKRFVQWQSSI
Alternative Products
Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q9H313-1; Sequence=Displayed; Name=2; IsoId=Q9H313-2; Sequence=VSP_029760; Name=3; Synonyms=TTYH1s; IsoId=Q9H313-3; Sequence=VSP_029759; Name=4; IsoId=Q9H313-4; Sequence=VSP_029753, VSP_029757, VSP_029760; Name=5; IsoId=Q9H313-5; Sequence=VSP_029754, VSP_029755, VSP_029756, VSP_029758
Alternative Sequence
1..212; Missing (in isoform 4); 1..85; Missing (in isoform 5); 86..101; GGGCVTWSCIVALLAG -> MEKVRLWRGSESRAAI (in isoform 5); 140..142; Missing (in isoform 5); 213; R -> M (in isoform 4); 376..450; DYGAALRGLCEDALEGLLFLLLFSLLSAGALATALCSLPRAWALFPPSDDYDDTDDDDPFNPQESKRFVQWQSSI -> VKPLPSQFLLPRGASVSTHRTTSSFSLDPCHCA (in isoform 5); 423..450; SDDYDDTDDDDPFNPQESKRFVQWQSSI -> RNPSALCSGSRLSEPLLPAGLEPGSPLRSFPGCRRRPH (in isoform 3); 437; P -> PQ (in isoform 2 and isoform 4)
3D Structural Models
3D Structure
Electron microscopy (1)
Domain & Motif Annotations
Region
428..450; Disordered
Protein Families
Tweety family
Sequence Similarities
Belongs to the tweety family.